Showing 76–100 of 180 documents
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Noah Kiwanuka, Alex Kityamuwesi, Rebecca Crowder, Kevin Guzman, Christopher A. Berger, et al.
…d over the treatment period and was lower among people with HIV (median 50.6% vs. 63.7%, p<0.001). People with TB received SMS dosing reminders on 90.5% of treatment days. Health worker support actions were documented for 261/409 (63.8%) people with TB who missed >3 consecu…
V.B. Avdentova, E.M. Belilovsky, Borisov Se, E. M. Bogorodskaya, O. N. Zuban, et al.
…om causes other than TB – OR = 3.4. Comorbidities (positive HIV status, chronic non-tuberculous pulmonary disease, mental disease, or diabetes mellitus) increased the risk of unfavourable outcomes with OR = 2.6, 2.0, 2.3 and 1.5 respectively. Advanced or acute progressive TB, spu…
Prajapati AC, Shah T, Panchal S, Joshi B, Shringarpure K, et al.
…o, 60.1% were male, 2.5% were human immunodeficiency virus (HIV) positive, 65.3% were pulmonary TB cases, and 70.4% obtained treatment from public providers. Proportion of "successful" and "unsuccessful" outcomes was 87.9% and 12.1%, respectively, in the new treatment category an…
Peter Okpeh Amede, Elizabeth Adedire, Aishat Bukola Usman, Celestine Ameh, Faruk Saleh Umar, et al.
… 1.4-65.6), ≥60 kg (AOR= 18.6; 95% CI: 2.5-140.1) and being HIV negative (AOR=3.3; 95% CI:1.4-7.8). Conclusion: The predictors of successful TB treatment outcome were being less than 40 years of age, having a pretreatment body weight of or greater than 50 kg, imprisonment for les…
Peter Okpeh Amede, Elizabeth Adedire, Aishat Usman, Celestine Ameh, Faruk Saleh Umar, et al.
…sonment for ≤ 2 years (AOR= 2.6; 95% CI: 1.3-5.4) and being HIV negative (AOR=3.3; 95% CI:1.4-7.8). Conclusion: The predictors of successful TB treatment outcome were being less than 40 years of age, having a pretreatment body weight of or greater than 55 kg, imprisonment for les…
Marx FM, Cohen T, Lombard C, Hesseling AC, Dlamini SS, et al.
…those with high case notification rates and lower antenatal HIV prevalence. Additional efforts to prevent TB among previously treated people, such as strengthening treatment monitoring and/or secondary preventive therapy, should be considered.
John Metcalfe, MD, PhD, MPH
…) tuberculosis (TB). Randomization was stratified based on HIV status and the presence of advanced disease as determined by chest X-ray. Participants were randomized to one of three arms: * Arm 1 (Experimental): rifapentine/isoniazid/pyrazinamide/ethambutol (PHZE) + CFZ 300 mg…
Gustavo Velásquez, MD, MPH, Patrick Phillips, PhD, Susan Dorman, MD
…n chest X-ray, age, BMI, sex at birth, diabetes status, and HIV status using the SPECTRA-TB risk algorithm prior to randomization. Those classified into the lower-risk group (consisting of the low and moderate risk randomization strata to facilitate balancing of risk within each …
Siame L, Chembe E, Muchaili L, Hamooya BM, Masenga SK
…ildren (below 19 years old) was 7.0% (n = 187). Living with HIV (AOR 1.75, 95% CI 1.00-3.08, p = 0.049) was positively associated with TB-related death among the adult patients while being on a family based direct observation therapy (DOT) plan was negatively associated with TB-r…
Felix Bongomin, Martha Namusobya, Ritah Nantale, Daniel S Ebbs, Charles Batte, et al.
…d a history of previous TB, and 34 (27.2%) were living with HIV. Coinfection with PTB and CPA was identified in 31 participants at baseline (24.8%). The median St. George's respiratory questionnaire score was 50.9 (interquartile range 40.9-63.3), and 32.0% (n = 40) had scores abo…
Alexandra V. Solovyeva, Grigory Volchenkov, O. Ponomarenko, Tatiana A. Kuznezova, Tatiana R. Somova, et al.
…ontacts, people experiencing homelessness, and persons with HIV who received TPT in Vladimir City, Russia, between 2019 and 2020. Those without TB disease but with indications for TPT were offered one of six regimens, based on drug-susceptible testing results of index patient: Ri…
Ridolfi F, Amorim G, Peetluk LS, Haas DW, Staats C, et al.
…comitant medication (CM) use, human immunodeficiency virus (HIV) status, glycated hemoglobin (HbA1c), age, body mass index (BMI), sex, substance use, and TB drug metabolism variables (NAT2 acetylator profiles). The models were developed through bootstrapped backward selection. Co…
Olanrewaju Oladimeji, Victor Abiola Adepoju, Felix Emeka Anyiam, James Emmanuel San, Babatunde A. Odugbemi, et al.
… were<br> male, 980 (59.04%), Human Immunodeficiency Virus (HIV) negative status, 1295<br> (80.24%) , diagnosed with smear, 1141 (73.14%), treated in private not-for-profit<br> (PNFP) hospital, 1097 (66.08%), treated for TB between 2014-2016 (18.96%-19.52%).<br> In multivariate a…
Grant Theron, PHD
…lity increases in people with human immunodeficiency virus (HIV) and other risk co-morbidities such as malnutrition, diabetes and substance abuse. Chronic microbial colonisation with unrelated bacteria are associated with TB pathogenesis (e.g., mice colonised with Helicobacter he…
Nicole Salazar-Austin, MD, ScM
…luating the safety of the HPZM in children with and without HIV. In previously untreated individuals with presumed drug-susceptible pulmonary and or peripheral lymph node TB treated with eight weeks of rifapentine, isoniazid, pyrazinamide and moxifloxacin (2HPZM), all given dail…
Christopher A. Berger, R. Crowder, A. Kityamuwesi, Noah Kiwanuka, M. Lamunu, et al.
…me Adjusted for time (trial month, discrete variable), sex, HIV status, disease class (bacteriologically confirmed vs.clinically diagnosed), TB type (new vs. retreatment) as fixed effects and site as a random effect ^ Proportion difference calculated as intervention minus control…
Cattamanchi A, Crowder R, Kityamuwesi A, Kiwanuka N, Lamunu M, et al.
…were women, mean (SD) age was 39.4 (14.4) years, 46.8% were HIV-infected, and most (91.4%) had newly diagnosed TB. In total, 463 (52.0%) patients were enrolled on 99DOTS during the intervention period. In the ITT analysis, the odds of treatment success were similar in the interve…
Kiwanuka N, Kityamuwesi A, Crowder R, Guzman K, Berger CA, et al.
…d over the treatment period and was lower among people with HIV (median 50.6% vs. 63.7%, p 3 consecutive doses. Surveys were completed by 83 people with TB and 22 health workers. Composite scores for capability, opportunity, and motivation were high; among people with TB, composi…
Butov D, Feshchenko Y, Kuzhko M, Gumenuik M, Yurko K, et al.
… meningoencephalitis (TM) and human immunodeficiency virus (HIV) co-infection in the intensive phase of treatment. Methods Fifty-four patients with TB/TM and HIV co-infection were enrolled for this study. Group 1 comprised of 23 patients treated with E and H intravenously, while …
Laura Diab Casares, Juan Espinosa Pereiro, María Teresa Tórtola Fernández, Xavier Casas García, Joan Pau Millet, et al.
… criteria include corrected QT interval (QTc) prolongation, HIV positive status, severely impaired blood counts or the use of QTc-prolonging drugs. The study will enrol 120 patients (60 per arm) over a 2.5-year period across 13 TB units in Spain. **ETHICS AND DISSEMINATION:** Th…
Robertson N, Porterfield J, Kayongo A, Kirenga B, Kalyesubula R, et al.
…eated TB. Among this subset of participants 21 (42.0%) were HIV positive, 9 (18.0%) were ever smokers, 6 (12.0%) were current smokers, and no participants had a prior COPD diagnosis. Mean (SD) age and body-mass index (BMI) at enrollment was 48.5 (SD 10.7) years and 22.2 (SD 3.9) …
Nicole Robertson, J. Zachary Porterfield, Alex Kayongo, Bruce Kirenga, Robert Kalyesubula, et al.
…eated TB. Among this subset of participants 21 (42.0%) were HIV positive, 9 (18.0%) were ever smokers, 6 (12.0%) were current smokers, and no participants had a prior COPD diagnosis. Mean (SD) age and body-mass index (BMI) at enrollment was 48.5 (SD 10.7) years and 22.2 (SD 3.9) …
Shanghai Public Health Clinical Center
…2HPMZ/2HPM regimen versus the 2HRZE/4HR regimen in treating HIV-associated drug-susceptible pulmonary tuberculosis (DS-TB) among patients with a CD4+ T-cell count \< 100 cells/μL. A total of 148 participants will be enrolled and randomized 1:1 into two groups: 74 cases in the 2HP…
Karolina Kėvelaitienė, Roma Puronaitė, Valerija Edita Davidavičienė, Birutė Nakčerienė, Edvardas Danila
…ovascular disease, chronic lung disease, diabetes mellitus, HIV, and renal failure.: Treatment outcomes for DS-TB in Lithuania have improved over the past two decades; however, certain modifiable risk factors-such as low BMI, homelessness, substance use, and comorbidities-remain …
Naomi Bock, MD
…he completion of induction phase therapy. Sample-size is 50 HIV-seronegative patients with culture-positive, drug susceptible TB in each treatment arm. The first 75 patients will be randomized 2:1 to 900 mg:600 mg rifapentine. The second 75 patients will be randomized 2:1 to 1200…