RISK FACTORS FOR UNFAVOURABLE TREATMENT OUTCOMES IN TUBERCULOSIS PATIENTS WITH PRESERVED DRUG SUSCEPTIBILITY

Objective: to determine the association of various patient characteristics with unfavourable treatment outcomes of adult pulmonary tuberculosis (TB) without multidrug resistance in a region with low epidemiological rates. Methods. We studied treatment outcomes in 887 drug-susceptible pulmonary TB patients aged over 17 years. We used univariate analysis to select factors with statistically significant association with an unfavourable outcome of TB treatment. The selected indicators were included in a multifactor analysis model based on the logistic regression method. Results. We established that the incidence of unfavourable treatment outcomes in pulmonary TB patients with preserved drug susceptibility increased with age. Patients from socially disadvantaged groups (unemployed/homeless, disabled, retired people) had 3.4 times higher risk of an unfavourable treatment outcome, the probability of death from TB – odds ratio (OR) = 18.4, treatment interruption – OR = 7.9, and death from causes other than TB – OR = 3.4. Comorbidities (positive HIV status, chronic non-tuberculous pulmonary disease, mental disease, or diabetes mellitus) increased the risk of unfavourable outcomes with OR = 2.6, 2.0, 2.3 and 1.5 respectively. Advanced or acute progressive TB, sputum positivity, cavities increased the probability of unfavourable outcomes with OR = 4.0–6.6, 1.4–1.5, 1.7 respectively. Conclusion. Unfavourable treatment outcomes of pulmonary TB with preserved drug susceptibility in Moscow permanent residents were associated with sociomedical status, age, and severity of the disease.