Showing 176–200 of 200 documents
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Manish K. Munda, Niranjan Kumar Sit, Rupam Kumar Ta, Dr Santanu Ghosh
Background: Drug resistance in tuberculosis is a global problem and India is no exception to this. However, this rise is mainly among the previously treated cases as previous antituberculosis therapy is the single most important risk factor for the development of drug resistance.…
Fadrian Fadrian, Khie Chen, July Kumalawati, Cleopas Martin Rumende, Hamzah Shatri, et al.
BACKGROUND: The emergence of drug-resistant pathogens (DRP) in recent years possibly contributes to the common problems associated with community-acquired pneumonia. However, to predict the risk of the ailment, the DRIP score is mainly applied, although no validation study has be…
C L Nagaraja, B L Shashibhushan, Mohammad Asif, PH Manjunath, Chandrasekhar Sagar
AIMS AND OBJECTIVES: To study the pattern of drug-resistance and treatment outcomes among patients with confirmed multidrug-resistant pulmonary tuberculosis (MDR-PTB). METHODS: A prospective study was conducted at Rajiv Gandhi Institute of Chest Diseases, Bengaluru, Karnataka, In…
Amitabh Das Shukla, Mohd Zulham Affandi Mohd Zahid, Abhishek Singh
…berculosis (TB) prevalence, especially India, are facing is drug-resistant TB. Fluoroquinolones (FQs) play an essential role in treating & controlling drug-resistant tuberculosis (DR-TB). Missense mutations found within the FQ resistance-determining region of the Mycobacteria…
Ashura Mayanda, Robert Kaaya, B. Sylvester, Reginald A. Kavishe
…1) and Theta 1 (GSTT1) have been reported to associate with drug resistance in cancer patients and also reported to influence the severity of malaria. This work aims to assess the effect of sex and human glutathione transferase null genotypes on TB drug resistance. The objectives…
Amirkan A Azembayev, Cond.Phar.Sc.
Drug-resistant tuberculosis is becoming a major problem for the whole humanity, and development of new Anti-TB drugs is of great importance. Since Kazakhstan is a country with the high burden of tuberculosis, the Government of the Republic of Kazakhstan has founded initiative on …
Rim Abbas, Ali Salami, Ghassan Ghssein
…oplet nuclei. Unfortunately, there has been an emergence of resistance to strains of such infections, such as multidrug- as well as extensively drug-resistant strains. Healthcare workers (HCWs) are particularly vulnerable to contracting TB due to their direct contact with patient…
Maria Rafique, Muhammad Ibrahim, Sumaira Kanwal, Habib Bokhari, Farrukh Jamil, et al.
Development of multidrug-resistant tuberculosis is the after effect of various mutational occasions, which leads to the development of protection from hostile to multiple tuberculosis drugs. In this study, we identified drug resistance genes, their evolutionary analysis, mutation…
Saira Salim, Syed Asim Ali Shah, Fareena Asim, Saba Anwar, Aniqa Shoukat, et al.
…e between genotypic and phenotypic methods for detection of drug resistant Mycobacterium tuberculosis. Material and Methods: This cross-sectional validation study was conducted from January to September 2024 in BSL-3 laboratories of Islamabad Diagnostic Center, Izzat Ali Shah Hos…
Mohammad Atif, Mohd Maroof, Sankalp Yadav
The emergence of drug-resistant tuberculosis is a major threat to tuberculosis care and control throughout the world. The lack of effective, affordable and safe drugs for the treatment of MDR-TB is a key factor in the inability of programs to boost up their treatment efforts to m…
Rubeshan Perumal, Neda Bionghi, Camus Nimmo, Marothi Letsoalo, Matthew J. Cummings, et al.
<h3>Tweetable abstract</h3> <b>Bedaquiline resistance is a major threat to drug-resistant tuberculosis control strategies. This analysis found a pooled prevalence of baseline bedaquiline resistance of 2.4% and a pooled prevalence of treatment-emergent bedaquiline resistance of 2.…
О. М. Raznatovska, V.I. Petrenko, О.S. Shalmin, R. М. Yasinskiy, A.V. Fedorec, et al.
…emporal bone tuberculosis in a patient with co-infection of drug-resistant tuberculosis/HIV infection is presented. The aim of the work was to identify risk factors, features of the clinical course, treatment and outcomes of temporal bone tuberculosis at drug-resistant tuberculos…
L.I. Rusakova, Daria Kucheryavaya, Tamara Izmailova
…comes in patients with TB, including multiple and extensive drug resistant TB (MDR/XDR-TB), in the Russian Federation in 2016–2020. Materials and methods. We used data from the state statistical observation and specialized inquiries. Results. During the five years the treatment s…
Sergey Saenko, Giller Db, G. V. Shcherbakova, O. Sh. Kesaev, В.В. Короев, et al.
…ehabilitation among patients who underwent surgery for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in the long-term period compared with patients who refused surgery and opted solely for conservative management. Material and methods : We analyzed l…
Soutrik Kundu, Sarvan Singh
The incidence of drug-resistant strains of Tuberculosis (TB) is rising at an alarming rate. With the emergence of newer drug-resistant strains, managing the disease with existing antitubercular agents is becoming increasingly difficult. Few studies exist regarding the treatment o…
Dr Prasobh G.R Vishnu priya. B. P
…e, development of ADR during treatment and the evolution of drug resistance. The drugs used in treatment have a higher proportion of side effects. The majority patients required treatment modification due to ADRs. The proper identification, reporting, management, or prevention ca…
Anisa Rachmita arianti, Syamsudin Syamsudin, Ros Sumarny, Lusi Nursilawati Syamsi
…g the 10 countries contributing to the highest incidence of drug-resistant tuberculosis each year. There are 12,794 cases of drug-resistant tuberculosis in Indonesia with 7,884 cases starting treatment. The number of drug-resistant tuberculosis cases involves a variety of risk fa…
Sümeyya Çapuk, Gülnur Tarhan, İsmail Ceyhan
Aim of the study: Multi-drug resistant tuberculosis (MDR-TB) is still an important public problem. Rapid diagnosis of the agent and determination of resistance status are critical in establishing the correct treatment protocol. This study was conducted with the aim of determining…
Muhammad Fachri, Mochammad Hatta, Fauziah Zafira, Risky Akaputra, Tri Ariguntar Wikanningtyas
…treat to understand the effects of TB and oral antidiabetic drugs. The purpose of this study was to compare the duration of treatment for drug-resistant pulmonary TB in the presence and absence of type 2 DM. Methods: This study used a cross-sectional design and single-population …
Mani Sharma, Sakshi Kansal
…are numerous factors responsible for the emergence of multi-drug resistance and extensively drug resistance cases of tuberculosis, which involves high pill burden, prolonged treatment, low compliance, and stiff administration schedules. Continuous efforts have been done to develo…
Usharani Brammachary, Venkateswari Ramachandra, Suganthi Palavesam, Vidya Raj Cuppusamy Kapalamurthy, Aaina Muralidhar, et al.
…ry TB regimens consist of 6–9 months of daily doses of four drugs in the existing regimen that is extremely toxic to patients. The purpose of these longer treatments is to eliminate Mycobacterium tuberculosis, notorious for its ability to resist most antimycobacterial drugs, ther…
Letemichael Negash Welekidan (9243532), Solomon Abebe Yimer (7860920), Eystein Skjerve (64644), Tsehaye Asmelash Dejene (5159135), Håvard Homberset (165283), et al.
…etic diversity and lineage-specific association of Mtb with drug resistance among pulmonary tuberculosis patients.</p><p>Methods: Sputum samples were collected from pulmonary tuberculosis patients at six different healthcare institutions in Tigray, Ethiopia, between J…
Asma Ansari, Mohammad Nadeem Khan, Shazia Mansoor
…Mycobacterium tuberculosis which is a global concern due to drug resistance. Recently there is an increase of 20% drug resistance strain of tuberculosis and some are resistant to more than one drug called multi – drug resistance tuberculosis (MDR – TB). To overcome this problem t…
Karthick Vedi, N Venkateswaramurthy, P. Dineshkumar, Satheesh Nagendrans
Introduction: Drug-resistant tuberculosis (TB), including multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), poses major global health challenges. Conventional regimens achieve only 50-60% success rates compared to 85% in drug-susceptible TB. This review exa…
Antonino Catanzaro, MD
…ys (line probe, pyrosequencing, and Microscopic Observation Drug Susceptibility Assay \[MODS\]) to detect resistance to first and second-line anti-tuberculosis (TB) drugs in Mycobacterium tuberculosis (Mtb) strains in 7 days or less, allowing for rapid diagnosis of extensively dr…