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Г. Н. Можокина, A. G. Samoylov, I. А. Vаsilyevа
…and the prospects of their use in the treatment of multiple drug resistant and extensively drug resistant tuberculosis. The article describes mechanisms of action of beta-lactams and macrolides on tuberculous mycobacteria; the results of studies and safety profiles are given.
Salman Khan, Nadeem ur Rehman, Mohammad Zubair, Nisar Khan
Abstract Background: Multidrug-resistant tuberculosis (MDRTB) is a growing global health concern that is a chronic danger to world health due to tuberculosis (TB). Objective: The aim of this study was to examine the frequency of both pre extensively drug-resistant tuberculosis (P…
Jieying Wang, Jinhui Dong, Zhuolin Chen, Yuni Xu, Wenhua Qiu, et al.
**OBJECTIVE:** Multidrug-resistant tuberculosis (MDR-TB) remains a major public health challenge in China. Hainan, China's largest tropical island, possesses distinct socio-geographical features. However, the drug resistance patterns and molecular epidemiology of MDR-TB in this r…
Gudisa Bereda
…levating number of second-line medicines used to treat multidrug-resistant tuberculosis are becoming a threat to public health worldwide. Recent guidelines recommended at least 20 months of treatment, but recent regimens are toxic, poorly tolerated and insufficiently effective, w…
Ganes Mahata, Rupam Kumar T. A, Pronoy Sen, Sandip Mukhopadhyay
The emergence of drug resistant mycobacterium has become a significant public health problem creating an obstacle to effective tuberculosis (TB) control. Freedom from TB is possible with timely, regular, complete treatment, with assurance, prevention and management of side effect…
Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi, Saeid Besharati, Ali Akbar Velayati
…ion, insertion, or substation occurred in susceptible, mono-drug and multidrug resistant-TB isolates were observed at PE-PGRS family protein Wag22 (Rv1759c) and PE_PGRS31 (Rv1768) at exponential phase. Although, a large deletion (at Rv1759c; Rv1768) was observed in extensively dr…
Mphande-Nyasulu FA, Puengpipattrakul P, Praipruksaphan M, Keeree A, Ruanngean K
…erall, 70.4% of cases were male and 29.6% were female. Mono-drug-resistant TB, multi-drug-resistant TB and extensively-drug-resistant TB were observed in 2.72%, 4.1% and 0.68% of cases, respectively. Although not statistically significant, individuals with comorbidities had a 2.1…
Rupam Kumar Ta, Pronoy Sen
BACKGROUND: The emergence of drug resistant mycobacterium has become a signicant public health problem creating an obstacle to effective Tuberculosis (TB) control. Freedom from TB is possible with timely, regular, complete treatment, with assurance, prevention and management of …
Pradeep M Muragundi
Introduction: Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown…
Monir BB, Sultana SS, Tarafder S
…um tuberculosis (MTB) contribute to regional differences in drug resistance. The emergence of pre-extensively drug resistant tuberculosis (Pre-XDR-TB) becomes obstacles to achieve End TB strategy in Bangladesh. This cross-sectional study was conducted to identify the strains of d…
Ketema DB, Alene M, Assemie MA, Yismaw L, Merid MW
Background The emergency of drug resistant tuberculosis is a major public health concern worldwide including Ethiopia. However, little is known about risk factors of mortality among drug resistant tuberculosis patients in the study site. Thus, this study was aimed to estimate the…
Bainomugisa A, Lavu E, Hiashiri S, Majumdar S, Honjepari A, et al.
An outbreak of multi-drug resistant (MDR) tuberculosis (TB) has been reported on Daru Island, Papua New Guinea. Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual of drug resistance mutations have not been described. Whole genome sequencing of 100 o…
Pan Y, Yu Y, Yi Y, Dou X, Lu J, et al.
Background Diabetes mellitus (DM) and drug-resistant tuberculosis (DR-TB) are serious global public health problems. This study aimed to explore the differences in drug resistance between DR-TB patients with and without DM. Risk factors for developing multidrug-resistant tubercul…
Chiang SS, Brooks MB, Jenkins HE, Rubenstein D, Seddon JA, et al.
Background Household contacts of patients with drug-resistant tuberculosis (TB) are at high risk for being infected with Mycobacterium tuberculosis and for developing TB disease. To guide regimen composition for the empirical treatment of TB infection and disease in these househo…
LaFreniere M, Dam D, Strudwick L, McDermott S
Background Drug-resistant tuberculosis (TB) is a public health issue of global importance that poses a threat to TB control efforts. Canada conducts nationwide surveillance to monitor emerging drug resistance trends and document progress towards reaching the goal of TB eliminatio…
Neetha S. Murthy, Sanjeev Nair, P. Ramya, Renu Susan George, B Ravikrishnan, et al.
Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine the genotypic drug resista…
Ghajavand H, Kargarpour Kamakoli M, Khanipour S, Pourazar Dizaji S, Masoumi M, et al.
…eness, it is essential to gain an in-depth insight into the drug resistance mechanisms of Mycobacterium tuberculosis ( M. tuberculosis ). Methods In this study, we evaluated the contribution of 26 drug efflux pumps plus target gene mutations to the drug resistance levels in multi…
Zhao JL, Liu W, Xie WY, Cao XD, Yuan L
…control of TB are greatly difficult, due to the increase in drug-resistant TB, particularly multidrug-resistant TB. We speculated that there were some differences between drug-sensitive and drug-resistant MTB strains and that mazEF 3,6,9 toxin-antitoxin systems (TASs) were involv…
Li Z, Liu F, Chen H, Han Y, You Y, et al.
…alence and significant clinical outcomes of pre-extensively drug-resistant plus additional drug-resistant tuberculosis (pre-XDR-plus) in Henan Provincial Chest Hospital between 2017 and 2021. Methods We analysed and summarized the drug sensitivity test (DST) results of clinical M…
Vinay Jasani, Ahmed Abdelaal, Mohamed Mohamed
…eption of the first antituberculous chemotherapeutic agent, drug resistance has been one of the most challenging problems facing the global fight to control tuberculosis. Drug resistance to antituberculous chemotherapy is a spectrum which includes mono-drug resistance (e.g. rifam…
Kübra Yıldırım, Cemilenur Ataş, Ece Şimşek, Ahmet Yılmaz Çoban
…evaluate the AYC-SENSITIVE® kit for rapid detection of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) isolates. With the AYC-SENSITIVE® kit, a total of 36 isolates for susceptibility testing were evaluated (5 of which are standard (…
…le and author information Metrics Abstract The emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of Mtb to identify novel gene…
Itu Singh, Utpal Sengupta
… continued till the appearance of primary and secondary DDS resistance during the 1970s.[45] Most of these DDS-resistant cases originated from fully treated relapse cases. However, it was noted that low doses of dapsone and irregular treatment were the major causes of relapse.[5]…
Yadav R, Saini A, Mankotia J, Khaneja R, Agarwal P, et al.
Rapid detection of drug resistance in Mycobacterium tuberculosis is important for the successful treatment of tuberculosis. Fluoroquinolone and aminoglycoside resistance detection by molecular methods becomes more complex due to cross resistance among them. Thus, we aimed to dete…
Shirin Tarafder, Bayzid Bin Monir
…a and to determine any relationship of these genotypes with drug resistance the most essential method is molecular typing. It allows a rapid and precise species differentiation. Objective: This study was intended to observe the genotypes of XDR mycobacterium tuberculosis by deter…