Showing 1–25 of 148 documents
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Inayati Inayati, Qori’atul Putri Nurmala, Hasto Nugroho
Multidrugs Resistant-Tuberculosis (MDR-TB) caused by drugs resistant at least Isoniazid and Rifampicin Mycobacterium tuberculosis affects tuberculosis cases eradication efforts in the world.In 2014, 153 countries had reported MDR TB cases.MDR-TB can be caused by irregularity in t…
Vidya Mave, Mandar Paradkar, Francesca Conradie, Amita Gupta, Anchalee Avihingsanon, et al.
Over the past 80 years, tuberculosis treatment has evolved with the development of all-oral treatments, which are now given for 4-6 months for drug-sensitive tuberculosis and 6-9 months for drug-resistant tuberculosis. Treatment success is often reduced among people with HIV due …
Md Abdur Rahim, Hoonhee Seo, Indrajeet Barman, Mohammed Solayman Hossain, Md Sarower Hossen Shuvo, et al.
Tuberculosis, primarily caused by, is an airborne lung disease and continues to pose a significant global health threat, resulting in millions of deaths annually. The current treatment for tuberculosis involves a prolonged regimen of antibiotics, which leads to complications such…
Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…
Qiuyue Song, Junlin Liu, Chunhua Wang
Tuberculosis is a severe infectious disease caused by(MTB) infection and poses a serious public health challenge globally. The prevalence of multidrug-resistant MTB in countries with a high burden of tuberculosis has further increased the challenges of tuberculosis prevention and…
Phool Chandra, Prashant Kumar, Surya Nath Pandey, Manoj Kumar Bisht
Tuberculosis (TB), developed by the Gram-positive bacterium Mycobacterium tuberculosis, is the prominent cause of demise globally due to high antibiotic resistance. Approximately 1.5 million people deceased of TB in 2020 worldwide. The causative pathogen of tuberculosis spreads m…
Alicia M Gutiérrez-Mauricio, Juan Valentín Trujillo-Paez, Luis Alberto Trejo-Martinez, Bruno Rivas-Santiago, Paola Pérez-García, et al.
Tuberculosis (TB) is a contagious infectious disease caused by the bacillus Mycobacterium tuberculosis (Mtb). It is transmitted through small particles in the air (<5 µm) expelled by active tuberculosis patients; when inhaled by a new host, they can potentially cause …
Xue‐Song Xiong, Qin Zhu, Zhan-Zhong Liu, Ting-Ting Huang, Jin-Bin Fan, et al.
…thogens in the genus Mycobacterium, including Mycobacterium tuberculosis (MTB) complex, nontuberculous mycobacteria (NTM), and Mycobacterium leprae. Tuberculosis caused by M. tuberculosis has become the leading cause of death of a single infectious disease after novel coronavirus…
Anca Ionela Fâcă, Denisa Ioana Udeanu, Andreea Letiția Arsene, Beatrice Mahler, Doina Drăgănescu, et al.
Tuberculosis is an infectious condition caused by, primarily targeting the pulmonary system, with the potential to disseminate to various other organs via the haematogenous pathway, ranking among the top ten causes of global mortality. Tuberculosis remains a serious public health…
Christian W. McMillen
Abstract Tuberculosis, caused by Mycobacterium tuberculosis, emerged in Africa about seventy thousand years ago. It accompanied modern humans on their migrations out of Africa, across the Indian Ocean, and then into Eurasia. Tuberculosis affects almost all parts of the body. Its …
Ravindra Kumar Garg
…SE OF REVIEW:** The outcome of central nervous system (CNS) tuberculosis has shown little improvement over several decades, with diagnosis remaining unconfirmed in nearly half of the cases. This review highlights current insights and advancements in the diagnosis and treatment of…
Amitesh Gupta, Eshutosh Chandra, Parul Mrigpuri
The intersection of diabetes mellitus (DM) and tuberculosis (TB) constitutes a significant global health challenge, marked by complex disease interactions with profound clinical and public health consequences. TB, a historically prevalent infectious disease, and DM, a rising non-…
Mani Sharma, Sakshi Kansal
Tuberculosis is the second most fatal infectious disease after AIDS. It is caused by the mycobacterium tuberculosis. There are numerous factors responsible for the emergence of multi-drug resistance and extensively drug resistance cases of tuberculosis, which involves high pill b…
Xiaoying Jin, Jiajun Wang, Yongdui Ruan, Jiaxiang Li, Xinen Kong, et al.
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most prevalent infectious diseases worldwide. Nitric oxide (NO) is produced by the reaction of arginine and oxygen catalyzed by nitric oxide synthase (NOS) in mammals. Several studies have highlighted the …
Thi Mai Nguyen, Emily Lai-Ho MacLean, Xiaomei Zhang, Sophia B Georghiou, Hui Xia, et al.
The paucity of diagnostic tests for isoniazid-resistant tuberculosis is concerning, given its status as the most common form of drug-resistant tuberculosis and a gateway to multidrug-resistant diseases. Molecular drug-susceptibility testing has improved access to timely diagnosis…
Rafael Laniado-Laborín
One-third of the world's population is infected with M. tuberculosis. It is from this vast pool of infected people where the new cases of active disease originate. Most of these cases of latent infection are found in low-income countries where national tuberculosis programs conce…
Rūta Mereškevičienė, Edvardas Danila
Tuberculosis remains a significant public health challenge globally. The emergence of multidrug-resistant Mycobacterium tuberculosis strains presents one of the biggest hurdles in tuberculosis management. Both first- and second-line tuberculosis drugs are associated with common a…
Aan Sutandi, Martika Hijriani, Apriana Rahmawati, Harizza Pertiwi
Multidrug-resistant tuberculosis (MDR-TB) is defined as tuberculosis caused by Mycobacterium tuberculosis strains resistant to at least isoniazid (INH) and rifampicin (RMP), confirmed through drug sensitivity testing or rapid molecular diagnostics (e.g., GeneXpert).Due to this re…
Benson Olu Akinshipe, Anthony Chukwuka Nwaobi, Emmanuel Babatunde Adedeji, Friday Alfred Ehiaghe, Herbert Obi Okpala
Host immune response against Mycobacterium tuberculosis (MTb) is mediated by cellular immunity in which cytokines and MTb-specific T cells play an important role. The detection of MTb and discrimination between different states of MTb infection is possible by immunodiagnostic tes…
Rosella Centis, Lia D'Ambrosio, Giovanni Battista Migliori
Tuberculosis is an airborne infectious disease treated with combination therapeutic regimens. Adherence to long-term antituberculosis therapy is crucial to maintain adequate blood drug level. The emergence and spread of drug-resistantstrains is mainly favored by the inadequate me…
Priya Shrivastava, Laxmikant Gautam, Anamika Jain, Nikhar Vishwakarma, Sonal Vyas, et al.
…an relations. Antibiotic resistant strains of mycobacterium tuberculosis have threatened the progress in management and control of worldwide epidemic of tuberculosis. Mycobacterium tuberculosis intrinsically resists many antimicrobials, limiting the number of compounds available …
K. Tamreihao, Saikat Mukherjee, Debananda S. Ningthoujam, Subhra Saikat Roy
…ation is infected with a deadly communicable disease called Tuberculosis (TB), caused by Mycobacterium tuberculosis. A majority of this infected population is confined in South-East Asia, especially India. With the emergence of multi-drug resistant (MDR) strains through the seque…
Gloria Guillermina Guerrero Manríquez
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTb). TB causes mortality of millions of people every year. Mycobacterium bovis Bacillus Calmette Güerin (BCG) is the only officially approved vaccine that protects against miliary TB and children bu…
Ming-Rui Sun, Jia-Yin Xing, Xiao-Tian Li, Ren Fang, Yang Zhang, et al.
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) in humans and animals. Mtb invades the host's lungs via airborne transmission, infecting macrophages and causing TB. In some cases, the infection can spread to other tissues and organs. Despite the avail…
Tatiana Chiriac, Evelina Lesnic, Serghei Ghindă, Ludmila Rudi, Liliana Cepoi
…ocytes collected form 65 patients, new cases with pulmonary tuberculosis (TB). The patients were distributed in the main study group, which included 34 cases with multidrug-resistant TB (MDR-TB), divided in the 1st study group with 12 cases with primary drug-resistance and the 2n…