The Role of Knowledge and Motivation in Multidrug-Resistant Tuberculosis (MDR-TB) Incidence

Multidrug-resistant tuberculosis (MDR-TB) is defined as tuberculosis caused by Mycobacterium tuberculosis strains resistant to at least isoniazid (INH) and rifampicin (RMP), confirmed through drug sensitivity testing or rapid molecular diagnostics (e.g., GeneXpert).Due to this resistance to first-line anti-tuberculosis medications, MDR-TB necessitates prolonged treatment with secondline drugs.This study aimed to analyze risk factors associated with MDR-TB incidence at a hospital in Bogor, Indonesia.A descriptive-analytical correlational study design with a cross-sectional approach was employed.Participants included 140 purposively sampled MDR-TB patients undergoing treatment for less than 24 months, confirmed by rapid molecular test results.Bivariate analysis using the chi-square test (significance threshold p < 0.05) revealed significant associations between MDR-TB incidence and patient knowledge about the disease (p = 0.044) as well as patient motivation (p = 0.047).These findings underscore the need for healthcare providers managing tuberculosis cases to integrate systematic knowledge assessments at initial diagnosis and continuous motivational support during treatment.Such strategies may reduce the likelihood of drug resistance development.