Tuberculosis Treatment History Influenced Multidrug-Resistant Tuberculosis (MDR-TB) Incidence Based on Gene-Xpert Examination

Multidrugs Resistant-Tuberculosis (MDR-TB) caused by drugs resistant at least Isoniazid and Rifampicin Mycobacterium tuberculosis affects tuberculosis cases eradication efforts in the world.In 2014, 153 countries had reported MDR TB cases.MDR-TB can be caused by irregularity in taking medication tuberculosis drugs and categorized as TB-relapse, TB-failure, and TB-drop out.Purpose To determine Tuberculosis treatment history influenced the incidence of Multidrugs-Resistant Tuberculosis (MDR TB).Methodology/Approach. Cross sectional studies in 88 TB-patients at dr. Ario Wirawan Hospital of Lung Salatiga examined by Gene Xpert MTB/RIF at August 2018 until March 2019.TB treatment history data obtained from TB-patients medical record.Findings.Eightyeight TB patients showed 43 (48.8%) were 26-45 years old, 50 (56.8%)were men.TB treatment history was 38 (43.2%) relapse, 13 (14.8%)failed and 11 (12.5%) drop out.Gene Xpert's examination results were 53 (60.2%)MDR TB Rifampicin resistant and 35 (39.7%)TB Rifampicin sensitive.Percentage of MDR TB Rifampicin resistant with history treatment TB Relaps were 25 (28.4%),Failed 9 (10.2%) and Drop out 11 (12.5%) and 8 (9.1%) for New-TB patient.TB treatment history influenced Multidrugs-Resistant Tuberculosis (MDR TB), p value 0.001, R value 0.228.Value/Implication -Regular awareness of taking medication tuberculosis drugs is important to avoid the incidence of MDR TB.