Showing 151–175 of 200 documents
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Lydia Gibango, Anna-Mari Reid, Jonathan L. Seaman, Namrita Lall
Tuberculosis is a prevalent disease that poses a serious threat to human health. Relevant and reliable research can help in improving tuberculosis control globally. Drug development is considered one of the top priorities in tuberculosis research, followed by diagnosis, diagnosti…
Soham Samajpaty
Mumbai Protocol is a shot in darkness in the field of tuberculosis research. At a time when clinicians around the world are obsessed with rifampicin to an extent of believing that no regimen against tuberculosis can work without it, the Mumbai protocol has opened a new avenue in …
V. R. Karthikayan, Anil Singh
…noma in a patient with multifocal small bowel strictures in tuberculosis endemic regions like India. Objective: The management of Small bowel adenocarcinoma is radically different from that of Intestinal tuberculosis and hence this article tries to highlight the importance …
Kaviyashruthi Thamilselvi Senthivel, Tatineni Saiteja, Beaulah Jeyavathana, M. Uma
Tuberculosis (TB) is one of the foremost global issues, especially in resource-poor setups that lack diagnostic equipment. This study seeks to generate highly advanced models using deep learning algorithms in order to autonomously detect tuberculosis and precisely visualize the a…
Pranay Sinha, Madhavi Bhargava, Madeline E Carwile, Madolyn R Dauphinais, Phumeza Tisile, et al.
Undernutrition-the leading risk factor for tuberculosis worldwide-is associated with impaired immunity, more extensive disease, delayed sputum conversion, and worse treatment outcomes, including mortality. In this Health Policy, we propose a comprehensive roadmap for integrating …
A.S. Rodrigues, Elisabete Calabuig Chapina Ohara, Lívia Mendes Oliveira, Nathália Lima Souza
INTRODUCTION: Tuberculosis (TB) is still a major public health problem worldwide. It is estimated that in 2019, worldwide, about ten million people evolved with TB and 1.2 million died due to the disease. As for treatment outcomes, in 2018, the percentage of treatment success was…
Isma Yuniar, Aswin Wahyono, Heri Purnomo
The World Health Organization (WHO) declares Tuberculosis (TB) as a very important and serious public health problem throughout the world and is a disease that causes a global because in most countries in the world pulmonary TB disease is uncontrolled, this is caused by the numbe…
Laura Olbrich, Nathan J L Mudrak, Ceri Evans, Padmini Salgame, Jerrold Ellner, et al.
…arly from infectious diseases. Given the high prevalence of tuberculosis in populations with high HIV prevalence, the effect of HIV exposure on tuberculosis is therefore of particular interest. In this Review, we contextualise and reflect on the existing literature for CHEU with …
Fatma Tokgöz Akyıl, Kamil Janeczek
Tuberculosis (TB) is one of the leading causes of death worldwide and the most common cause of death from a single infectious agent. TB is caused by the droplet transmission of Mycobacterium tuberculosis (M. tuberculosis) bacilli, which sick people shed into the air. About a quar…
Heini Hakosalo
…akes use of an extensive collection of written, unpublished tuberculosis-related illness narratives to analyze the experience of tuberculosis and tuberculosis sanatoria “from below” within the context of twentieth-century Finland. Hakosalo argues that by linking their personal il…
Pamela Pei, Livia Qoshe, Grady Florance, Ankur Pandya, Milton C Weinstein, et al.
…hetical trial comparing mortality associated with different tuberculosis screening strategies among hospitalized patients with human immunodeficiency virus (HIV) in South Africa. Apart from expressing VOI as conventional, "aggregated" net monetary benefit (NMB), we assessed "disa…
Özlem Abakay, Menduh Oruç
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Mycobacterium tuberculosis is transmitted by inhalation of droplets. Medication is the main component of TB treatment. When starting tuberculosis treatment, first a case definition is made and the treatment regi…
Yuki Sakai, Miki Miyazawa, Akifumi Hisada, Yukari Tanabe, Satoshi Arakawa, et al.
…terium tilburgii is the causative agent of disseminated non-tuberculosis mycobacterial infections in individuals who are immunocompromised, including those with human immunodeficiency virus infection. Owing to its non-culturable nature, identification of M. tilburgii relies solel…
Elly van Riet, Björn Corleis, Birgitte K Giersing, Mark Hatherill, Erlina Burhan, et al.
In 2021, a global tuberculosis vaccine research and development roadmap proposed a series of actions to accelerate the development of new, effective, and affordable vaccines that are urgently needed to eliminate tuberculosis globally. Since then, the pipeline has diversified, sev…
Priya Yadav, Sheetal Gandotra
… requiring tight regulation during infection. Mycobacterium tuberculosis, the causative agent of tuberculosis and the leading cause of death from a single infectious agent, exemplifies an extreme adaptation to lipid-rich environments. Recent studies have uncovered coordinated hos…
Ahmad Faris Daradkeh, Basil Alawyia, Hassan Ballas, Nikolaos Spernovasilis, Danny Alon-Ellenbogen
Tuberculosis continues to represent a major occupational risk in healthcare environments, particularly for healthcare workers who have persistent contact with patients who may be infectious. Despite the high occupational burden of tuberculosis among healthcare workers, there rema…
John Dawi, Scarlet Affa, Yura Misakyan, Edgar Gonzalez, Stephen Affa, et al.
Tuberculosis and coronavirus disease 2019, also known as COVID-19, remain major global health challenges that disproportionately affect individuals with metabolic disorders, chronic inflammation, and limited access to healthcare. Although these diseases are caused by different pa…
Manjula Datta, M P Radhamani, Manjula Singh, Soumya Swaminathan, Rema Mathew, et al.
**BACKGROUND AND OBJECTIVES:** A study of tuberculosis in children was undertaken in the outpatient departments of four hospitals in Chennai city by the Tuberculosis Research Centre of the Indian Council for Medical Research. The objective of this partial analysis was to assess t…
Pankti C. Balar, Bedanta Bhattacharjee, Dixa A. Vaghela, Lalitkumar K. Vora, Vasso Apostolopoulos, et al.
Tuberculosis (TB) remains a global health challenge, necessitating innovative strategies to enhance prevention, diagnosis, and treatment. The present chapter explores cutting-edge developments in the field of TB control, with a specific focus on the pivotal roles played by vaccin…
Swati Jaiswal, Samreen Fatima, Erandi Velarde de la Cruz, Satyendra Kumar
…ite significant advances in research over the past century, Tuberculosis (TB) remains a formidable global health concern. TB granulomas are organized structures composed of immune cells, that serve as the body's primary defense against the spread of Mycobacterium tuberculosis (Mt…
Daniel L. Clemens
Mycobacterium tuberculosis subverts the normal membrane trafficking pathway of the host cell: it prevents the maturation and acidification of its phagosome, and thereby achieves a phagosome that is hospitable for its growth. The composition of the phagosome and the interactions b…
K. S. Mithra
Tuberculosis (TB) is one of the worst lung infections caused by bacteria called Mycobacterium tuberculosis. It is a disease that can be controlled in cases where it is quickly identified and treated. As sputum microscopy is a simple and low-cost approach, most countries use this …
Gabriela Sadigurschi, Maria Cristina Caetano Kuschnir, Ewerton Alves Portela Dos Santos, Bruno Rangel Antunes da Silva, Celia Menezes Cruz Marques, et al.
Tuberculosis (TB) is a preventable and curable disease caused by the bacillus Mycobacterium tuberculosis. In 2022, according to the World Health Organisation (WHO), TB was the second leading cause of death worldwide caused by a single infectious agent, after coronavirus disease (…
Meenu K. Sharma, Quinn Wonitowy, Hafid Soualhine
The Mycobacterium tuberculosis complex (MTBC) is comprised of species M. tuberculosis, M. bovis including M. bovis BCG (vaccine strain), M. caprae, M. pinnipedii, M. africanum, M. microti, M. canettii, “M. mungi”, and “M. orygis” (Woods et al., Susceptibility testing of mycobacte…
Manjula Singh, Tahziba Hussain, Bhavesh Modi, Sanjeev Nair, Sunil Kumar, et al.
…ves Only 10% of the individuals infected with Mycobacterium tuberculosis (MTB) manifest active tuberculosis. Interferon-γ release assay (IGRA) and tuberculin skin test using purified protein derivative (PPD) are used to identify tuberculosis (TB) infection. We aimed to stud…