A Safer and More Efficacious Regimen for Fast Remission of Pulmonary Tuberculosis

Mumbai Protocol is a shot in darkness in the field of tuberculosis research. At a time when clinicians around the world are obsessed with rifampicin to an extent of believing that no regimen against tuberculosis can work without it, the Mumbai protocol has opened a new avenue in the practice of medicine. The popular regimen comprising of rifampicin, ethambutol, pyrazinamide and isoniazide had ample number of adversities. The main challenge in this regimen was treating patients with hepato-pathology, as all of these drugs are highly hepatotoxic. Even they have shown to cause drug induced hepatic failure in healthy individuals. The Mumbai protocol negates all these. It comprises of Streptomycin, cycloserine, p-amino salicylic acid and ethambutol. A complete remission of pulmonary tuberculosis was noticed utilizing this regimen in just one month with improvement in liver function. The objective of this study was to identify and develop a more efficacious and safer drug combination therapy for successful and fast remission of tuberculosis; which has been efficiently fulfilled.