Showing 1–25 of 200 documents
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Grace AG, Mittal A, Jain S, Tripathy JP, Satyanarayana S, et al.
…eople do not complete this full course. Shortened treatment regimens that are equally effective and safe could improve treatment success. Objectives To evaluate the efficacy and safety of shortened treatment regimens versus the standard six-month treatment regimen for individuals…
Maral Budak, Joseph M. Cicchese, Pauline Maiello, H. Jacob Borish, Alexander G. White, et al.
…ng more effective and more patient-friendly antibiotic drug regimens to increase patient compliance and decrease emergence of resistant TB. Moxifloxacin is one promising antibiotic that may improve the current standard regimen by shortening treatment time. Clinical trials and in …
Abidi S, Achar J, Assao Neino MM, Bang D, Benedetti A, et al.
…tiveness of two World Health Organization (WHO)-recommended regimens for the treatment of rifampin- or multidrug-resistant (RR/MDR) tuberculosis (TB): a standardised regimen of 9-12 months (the "shorter regimen") and individualised regimens of ≥20 months ("longer regimens").We co…
Park HY, Kwon JW, Kim HL, Kwon SH, Nam JH, et al.
Background Regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) have been changed from injectable-containing regimens to all-oral regimens. The economic effectiveness of new all-oral regimens compared with conventional injectable-containing regimens was scarcel…
Budak M, Cicchese JM, Maiello P, Borish HJ, White AG, et al.
…ng more effective and more patient-friendly antibiotic drug regimens to increase patient compliance and decrease emergence of resistant TB. Moxifloxacin is one promising antibiotic that may improve the current standard regimen by shortening treatment time. Clinical trials and in …
Lin KY, Sun HY, Yang CJ, Lu PL, Lee YT, et al.
…erience with combinations of short-course rifapentine-based regimens and integrase strand-transfer inhibitor-containing antiretroviral therapy (ART) in management of latent tuberculous infection (LTBI) is limited among people with human immunodeficiency virus (PWH). Methods From …
Hissar S, Velayutham B, Tamizhselvan M, Rathinam S, Arunbabu C, et al.
Background Tuberculosis (TB) lymphadenitis is the most common form of extra-pulmonary TB, and the treatment duration is six months. This non-inferiority based randomized clinical trial in South India evaluated the efficacy and safety of a four-month ofloxacin containing regimen i…
Happiness Cornel Mvungi, Peter Masunga Mbelele, Kassim Salim Msaji, Stellah George Mpagama, Hadija Hamis Semvua
… Health Organization recommended all-oral bedaquiline-based regimens, but evidence comparing their effectiveness to injectable-containing regimens is limited. This study evaluated treatment success between both approaches. **METHODS:** This was a retrospective study, which inclu…
Zainabadi K, Vilbrun SC, Mathurin LD, Walsh KF, Pape JW, et al.
…g-resistant tuberculosis (DR-TB). How these new second-line regimens fare in comparison to first-line regimens for treatment of drug-sensitive tuberculosis (DS-TB) is not well known. Methods In this study, we contemporaneously enrolled subjects with DS-TB (n = 31) or DR-TB (n = 2…
Soedarsono Soedarsono
… prolonged QT side effects are also neededto prevent switch regimens that can affect the patient’s psychological condition.
Jie Tan, Jun Huang, Jin Wang
…dy aimed to evaluate the efficacy of bedaquiline-containing regimens versus conventional regimens for cavitary MDR-PTB based on CT imaging. This retrospective study included 100 patients with cavitary MDR-PTB treated from June 2023 to June 2025. Patients were divided into a Conve…
Ashwin Karnan, Ulhas Jadhav, Babaji Ghewade, Vivek Alone
…reatment. Evaluating the effectiveness of various treatment regimens is crucial for identifying the best balance among treatment duration, efficacy, adverse drug effects, and patient adherence. A prospective, observational study on 50 MDR-TB patients was carried out at a tertiary…
Abangah G, Raughani A, Asadollahi P, Asadollahi K
Aim This study compares the effects of two drug regimens for Helicobacter pylori ( H. pylori ) infection resistant to the first line drug regimen among patients referred to Ilam clinics, Iran. Background Single drug regimen is not effective for H. pylori infection and therefore, …
Katherine Cobb, Aline Wilson, Nikolas Rae, Neil Stevenson
…fety data is awaited, compassionate use of alternative drug regimens within strict monitoring guidelines should be considered.
Tsong H. Chang, Yuxia Zhang, Yanming Sun, Zhiyuan Zhao, Fengxia Liu, et al.
…(RR) TB patients who were switched to contezolid-containing regimens due to adverse reactions during treatment with linezolid-containing regimens were included. Linezolid was administered 600mg once daily for 6-24 weeks, contezolid was given 400mg twice daily for 4 months to 1 ye…
Shah I, Antony S, Jaiswal A, Bodhanwala M, Shah D, et al.
Introduction The prevalence of multidrug resistant (MDR) tuberculosis (TB) with additional resistance to fluoroquinolones or second-line injectables (MDRFQ/SLI)/extensively drug-resistant TB (XDR-TB) in children is high in Mumbai. There are limited therapeutic options available i…
National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this study is to compare a 6-month regimen of high-dose rifampicin (RIF), high-dose isoniazid (INH), linezolid (LZD), and pyrazinamide (PZA) versus the World Health Organization (WHO) standard of care (SOC) treatment for tuberculosis meningitis (TBM). Rationale: T…
Soumana Boubacar Soumana, Abdourahamane Yacouba, Cheikh Aboubacar Abdoul Lawi, Ibrahim Oumar, Bassirou Souleymane, et al.
Background The emergence of extensively drug-resistant tuberculosis (XDR-TB) poses a serious challenge to global tuberculosis control, particularly in high-burden countries like Niger. In 2021, a new fully oral, shorter treatment regimen, named regimen C, was adopted nationally. …
Ji L, Yang W, Gao LJ, Zhang BY, Xu YQ, et al.
…ts often cannot tolerate traditional intensive chemotherapy regimens, and finding the optimal timing in the treatment of both AML and active pulmonary TB is complex. Neglecting timely treatment can lead to serious complications and even fatal outcomes. The present paper reports t…
Ghosh R, Roy S, Rashid MK
Purpose The Revised National Tuberculosis Control Programme (RNTCP) is now introducing daily fixed-dose regimen instead of Directly Observed Treatment, Short Course (DOTS) regimen for treatment of drug-sensitive tuberculosis (TB) in India. It would be beneficial to understand the…
Zh. T. Zhandauletova, Е. И. Никишова, А. O. Мaryandyshev, K. S. Serikbaeva, M. M. Adenov, et al.
…he objective : to assess the safety and compliance with new regimens for preventive treatment of drug susceptible and drug resistant tuberculosis. Subjects and Methods . The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high …
Jefman Efendi Marzuki HY, Nafrialdi N, Sawitri N, Sugiri YJ, Gusti Agung Ayu Putu Sri Darmayani I, et al.
…DR-TB patients on DLM regimen compared to shorter treatment regimens (STR). Methods A retrospective cohort was implemented on secondary data obtained from two participating hospitals. The QTc interval and the changes in QTc interval from baseline (ΔQTc) were assessed every 4 week…
Karnappa Bhangari, Basavaraj Sangolli, H. N. Jagadeesha
A comparative assessment of daily dosage regimen versus intermittent treatment regimen of tuberculosis at the RNTCP centres in Chitradurga district - IJIRM- Print ISSN No: - 2581-4214 Online ISSN No:- 2581-4222 Article DOI No:- 10.18231/j.ijirm.2020.037, IP Indian Journal of Immu…
Inbaraj LR, Manesh A, Ponnuraja C, Bhaskar A, Srinivasalu VA, et al.
… up for 1 year after the treatment. DISCUSSION: Current WHO regimens have agents with poor central nervous system drug exposure and is too long. It does not reflect the accumulating evidence in the field. We propose a comprehensive clinical trial incorporating the emerging eviden…
Moti Chapagain, Tawanda Gumbo, Scott K. Heysell, Shashikant Srivastava
…in and ethambutol. Unfortunately, therapy duration for both regimens lasts for years. In this study, we administered tedizolid, minocycline, clarithromycin, and rifapentine as monotherapy as well as novel combinations in the intracellular hollow-fiber model system of M. kansasii …