TB Research

Perinatal transmission and cure of extensively drug-resistant tuberculosis in an infant.

V Singh, R Perumal, M Wessels, F Hai, K Lutchminarain, K Naidoo, K Swe Swe-Han

African journal of thoracic and critical care medicine · 2025-01

Abstract

We describe a rare case of perinatally acquired extensively drug-resistant tuberculosis in an infant. The infant was successfully treated with an individualised all-oral multidrug regimen containing delamanid, a drug rarely described in the treatment of perinatal tuberculosis.This brief report offers insight into a clinical case of perinatally acquired extensively drug-resistant tuberculosis (XDR-TB), and outlines the individualised treatment plan that led to a successful treatment outcome.The report highlights the need for evidence-based guidance on XDR-TB in this paediatric population, as well as further research on preventive strategies for mitigating mother-to-child transmission of TB.