TB Research

Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby

Alison Boast, Jeu Ann How, Charis Lau, Arun Sett, Damien Gilby, Andrew Burke, Brett McWhinney, C. Melville Wright∗, et al. (13 authors)

Clinical Infectious Diseases · 2023-09

Abstract

We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including bedaquline and delamanid, drugs not previously described in the treatment of congenital tuberculosis (TB).

MeSH terms

  • Medicine
  • Tuberculosis
  • Regimen
  • Pediatrics