Showing 1–25 of 200 documents
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Grace AG, Mittal A, Jain S, Tripathy JP, Satyanarayana S, et al.
…eople do not complete this full course. Shortened treatment regimens that are equally effective and safe could improve treatment success. Objectives To evaluate the efficacy and safety of shortened treatment regimens versus the standard six-month treatment regimen for individuals…
Maral Budak, Joseph M. Cicchese, Pauline Maiello, H. Jacob Borish, Alexander G. White, et al.
…ng more effective and more patient-friendly antibiotic drug regimens to increase patient compliance and decrease emergence of resistant TB. Moxifloxacin is one promising antibiotic that may improve the current standard regimen by shortening treatment time. Clinical trials and in …
Hissar S, Velayutham B, Tamizhselvan M, Rathinam S, Arunbabu C, et al.
Background Tuberculosis (TB) lymphadenitis is the most common form of extra-pulmonary TB, and the treatment duration is six months. This non-inferiority based randomized clinical trial in South India evaluated the efficacy and safety of a four-month ofloxacin containing regimen i…
Abangah G, Raughani A, Asadollahi P, Asadollahi K
Aim This study compares the effects of two drug regimens for Helicobacter pylori ( H. pylori ) infection resistant to the first line drug regimen among patients referred to Ilam clinics, Iran. Background Single drug regimen is not effective for H. pylori infection and therefore, …
Ji L, Yang W, Gao LJ, Zhang BY, Xu YQ, et al.
…ts often cannot tolerate traditional intensive chemotherapy regimens, and finding the optimal timing in the treatment of both AML and active pulmonary TB is complex. Neglecting timely treatment can lead to serious complications and even fatal outcomes. The present paper reports t…
Ghosh R, Roy S, Rashid MK
Purpose The Revised National Tuberculosis Control Programme (RNTCP) is now introducing daily fixed-dose regimen instead of Directly Observed Treatment, Short Course (DOTS) regimen for treatment of drug-sensitive tuberculosis (TB) in India. It would be beneficial to understand the…
Karnappa Bhangari, Basavaraj Sangolli, H. N. Jagadeesha
A comparative assessment of daily dosage regimen versus intermittent treatment regimen of tuberculosis at the RNTCP centres in Chitradurga district - IJIRM- Print ISSN No: - 2581-4214 Online ISSN No:- 2581-4222 Article DOI No:- 10.18231/j.ijirm.2020.037, IP Indian Journal of Immu…
Moti Chapagain, Tawanda Gumbo, Scott K. Heysell, Shashikant Srivastava
…in and ethambutol. Unfortunately, therapy duration for both regimens lasts for years. In this study, we administered tedizolid, minocycline, clarithromycin, and rifapentine as monotherapy as well as novel combinations in the intracellular hollow-fiber model system of M. kansasii …
Andi Ibnu, Hajar Azis, Ngakan Putu, Persama Putra, Teguh Rahayu Sartono, et al.
however, there was persistence of A repeat chest scan showed interval development of cavity formation with no significant change in size of the mass lesion. The patient was referred to thoracic surgery and underwent right lower lobectomy. Intra-operative findings include a well-c…
Alex Nachman, Zain Chagla
CLINICAL IMPACT RATINGS: GIM/FP/GP: [Formula: see text] Infectious Disease: [Formula: see text] Pulmonology: [Formula: see text].
Sacks HS
Source citation Paton NI, Cousins C, Suresh C, et al; TRUNCATE-TB Trial Team. Treatment strategy for rifampin-susceptible tuberculosis. N Engl J Med. 2023;388:873-887. 36808186.
Kelly Dooley, MD, Daniel W Fitzgerald, MD, Ekaterina V Kurbatova, MD, PhD, MPH, Wendy Carr, PhD
…se of this study is to determine whether one or two 17-week regimens of tuberculosis treatment bedaquiline (B or BDQ), moxifloxacin (M), pyrazinamide (Z)-- (BMZ) plus either Rifabutin (Rb) or Delamanid (D or DLM) are as effective as a standard six-month regimen for treatment of p…
Sisay M, Edessa D, Ayele Y, Getachew M
…pattern of and reasons for change of antiretroviral therapy regimens among HIV/AIDS patients at Jugel Hospital, Eastern Ethiopia. Methods A retrospective cross-sectional study was conducted to review medical records of 220 patients who had been on treatment and experienced regime…
Ryckman TS, McQuaid CF, Cohen T, Menzies NA, Kendall EA
…of separate rifampicin-susceptible and rifampicin-resistant regimens. We estimated incremental cures; averted deaths, secondary cases, and costs; and prices below which a pan-tuberculosis regimen would be cost saving. We also assessed scenarios intended to describe which mechanis…
Masayuki Ikeda, Hiroki Matsui, Yasuhiro Morimoto, Norihiko Kubota, Tatsuya Nagai, et al.
…%) patients received clarithromycin- and azithromycin-based regimens, respectively. The aORs for initial regimen modification were as follows; age 1.05 (95% CI; 1.01-1.10), women 0.77 (95% CI; 0.34-1.74), body mass index 1.06 (95% CI; 0.96-1.18), smear-positive status 0.85 (95% C…
Narendran Gopalan, DNB (Chest), Soumya Swaminathan, MD
…dividuals treated for TB treated with standard intermittent regimens. The study would generate data on the efficacy of daily and thrice weekly regimen of ATT in pulmonary TB patients with HIV in the presence of highly active antiretroviral therapy (HAART). Not many trials have co…
Hisayuki Shuto, Kosaku Komiya, Akihiko Goto, Takamasa Kan, Kokoro Honjo, et al.
…ficacy and safety of fluoroquinolone-containing combination regimens as an alternative remain uncertain. This study aimed to compare the efficacy and safety of fluoroquinolone-containing regimens with those of the standard regimens for treating pulmonary MAC disease. METHODS: We …
Azmeraw M, Workineh Y, Girma F, Kassaw A, Kerebeh G, et al.
…rtant to maintain children's initial antiretroviral therapy regimens. However, the incidence and predictive factors of initial antiretroviral therapy regimen changes in the research context are still unknown in the study setting. So, the study was aimed to assess incidence and pr…
Lyndon P. James, Fayette Klaassen, Sedona Sweeney, Jennifer Furin, Molly F. Franke, et al.
…ging evidence suggests that shortened, simplified treatment regimens for rifampicin-resistant tuberculosis (RR-TB) can achieve comparable end-of-treatment outcomes to longer regimens. We compared a 6-month regimen containing bedaquiline, pretomanid, linezolid, and moxifloxacin (B…
Velayutham B, Jawahar MS, Nair D, Navaneethapandian P, Ponnuraja C, et al.
…iority. We tested the efficacy and safety of 3- and 4-month regimens containing moxifloxacin in a randomised clinical trial in pulmonary TB (PTB) patients in South India. Methods New, sputum-positive, adult, HIV-negative, non-diabetic PTB patients were randomised to 3- or 4-month…
Stagg HR, Thompson JA, Lipman MCI, Sloan DJ, Flook M, et al.
… nonadherence occurs on the forgiveness of antituberculosis regimens. Methods: Using data from three randomized controlled trials comparing experimental 4-month regimens for drug-sensitive tuberculosis with the standard 6-month regimen, we used generalized linear models to examin…
Nicholas I Paton, Christopher Cousins, Intan P Sari, Erlina Burhan, Nan-Kai Ng, et al.
…D:** WHO recommends a 2-month optimal duration for new drug regimens for rifampicin-susceptible tuberculosis. We aimed to investigate the efficacy and safety of the 8-week regimens that were assessed as part of the TRUNCATE management strategy of the TRUNCATE-TB trial. **METHODS…
Vesga JF, Lienhardt C, Nsengiyumva P, Campbell JR, Oxlade O, et al.
…en important improvements in available preventive treatment regimens for tuberculosis (TB), and research is ongoing to develop these further. To assist with the formulation of target product profiles for future regimens, we examined which regimen properties would be most influent…
Srikant Kashinath Malegaonkar, Valliappan Muthu, Ashutosh N. Aggarwal, Digambar Behera, Ritesh Agarwal
… article by Velayutham and colleagues, reporting on shorter regimens for newly diagnosed pulmonary tuberculosis [1]. Shortening the duration of tuberculosis treatment is an unmet research need [2]. In this regard, the trial by Velayutham et al. is commendable. Nevertheless, it ha…
Liu Y, Pertinez H, Davies GR, Gillespie SH, Coates AR, et al.
…oxifloxacin for isoniazid or ethambutol in standard anti-TB regimens reduces the treatment duration and relapse rates in animal studies, and 4-month regimens were not noninferior in clinical trials. Resuscitation-promoting factor (RPF)-dependent bacilli have recently been implica…