Showing 1–25 of 93 documents
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Bhosale S, Prabhakar A, Srivastava S, Raj A, Purohit S, et al.
…of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a rise and there is inadequate literature concentrating on the precise pattern of resistance in Indian subcontinent which harbors 24% of global prevalence. The ai…
Sahjid Mukhida, Chanda Vyawahare
…ng are not in common people regarding various categories of drug-resistant TB (DRTB).[2] They don’t have awareness and differentiation about mono-resistant, multidrug-resistant (MDR), poly-drug-resistant (pDR), pre-extensive drug resistance (Pre-XDR), extensive drug resistance (X…
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
DK Mumena, Geoffrey Kwenda, CW Ngugi, AK Nyerere
Background: Drug-Resistant Tuberculosis (DR-TB) is one of the major public health issues globally. Zambia is highly burdened by TB and multi-drug resistant TB. In this study, sputum samples obtained from the new and previously treated cases of TB were examined for drug-resistant …
R Santosh
Introduction: Drug-resistant tuberculosis is a major public health problem throughout world. India accounts for 27% of global TB burden. More than half of TB patients in India are cared for in private sector. Usage of inappropriate TB diagnostic, treatment practices and lack of a…
Diriba G, Kebede A, Tola HH, Alemu A, Yenew B, et al.
…s limited information available on lineages associated with drug resistance among extrapulmonary tuberculosis patients in Ethiopia. In this study, researchers looked into Mycobacterium tuberculosis lineages linked to drug resistance in patients with extrapulmonary tuberculosis in…
Yang Che, Tianfeng He, Lin Lyu, Ping Guo-hua
…e the characteristics of second-line anti-tuberculosis (TB) drugs resistance and gene mutation of multidrug-resistant (MDR) Mycobacterium tuberculosis isolated in Ningbo. Methods In 1597 M. tuberculosis isolates collected in the first drug resistance survey in Ningbo between 2018…
Yu. D. Mikhailova, Marina Makarova, L. Yu. Krylova, S. G. Safonova, В. И. Литвинов
Due to the widespread drug resistance of M. tuberculosis (MTB), it is necessary to assess the possibility of using drugs with antimycobacterial activity previously used in other pathologies, e.g. clofazimine, in anti-tuberculosis chemotherapy regimens. The aim was to determine th…
Schami A, Islam MN, Wall M, Hicks A, Meredith R, et al.
In recent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health. Although M.tb's complex and protective cell envelope has been widely studied, little is known about how levels of periphe…
Dagne B, Desta K, Fekade R, Amare M, Tadesse M, et al.
Background Drug-resistance in Mycobacterium tuberculosis complex remains a major health burden in human history and still is a major leading cause of death in developing countries including Ethiopia. Early detection of all forms of drug-resistant Tuberculosis(TB) is a key factor …
Beauty Makamure, Dan Ward, Tsitsi Bandason, Martha Chipinduro, Collins Timire, et al.
Background: Drug-resistant tuberculosis (DR-TB) is a major public health issue in Zimbabwe. Whole-genome-sequencing (WGS) is recommended for studying drug-resistant mutations, lineages, prevalence, and transmission patterns. However, there are limited data on drug-resistant confe…
Liang D, Song Z, Liang X, Qin H, Huang L, et al.
…lic health issue in China. Nevertheless, the prevalence and drug resistance characteristics of isolates vary in different regions and provinces. In this study, we investigated the population structure, transmission dynamics and drug-resistant profiles of Mtb in Guangxi, located o…
Ulan Kozhamkulov, Asset Daniyarov, Ainur Akhmetova, Saule Rakhimova, Zhannur Abilova, et al.
…pulation. The aim of this study was the characterization of drug-resistant (DR) <i>M. tuberculosis</i> (MTB) collected in Kazakhstan and to perform pilot whole genome sequencing for drug resistance detection. Drug susceptibility testing to first/second-line anti-TB drugs was done…
Kostyukova I, Pasechnik O, Mokrousov I
Russia is a high-burden area for multidrug-resistant tuberculosis (MDR-TB). Here, we studied the epidemiological situation and drug resistance patterns of Mycobacterium tuberculosis in the Omsk region in Western Siberia. M. tuberculosis isolates ( n = 851) were recovered from new…
Sarmat Z. Suleimanov, M. V. Sinitsyn, I. V. Golubenkov, L. E. Parolina, O. V. Lovаchevа, et al.
The objective: to compare the spectrum of drug resistance of Mycobacterium tuberculosis obtained from respiratory and surgical specimens of pulmonary tuberculosis patients. Subjects and Methods . A non-randomized, continuous, single-center retrospective study was performed and in…
Liang Z, Liao W, Chen Q, Li H, Ye M, et al.
Drug-resistant tuberculous meningitis (TBM) is the most devastating and critical form of extrapulmonary tuberculosis. Here, we present a case of a 45-year-old male with pre-extensive drug-resistant tuberculosis meningitis (pre-XDR-TBM). He underwent emergency surgery for the long…
Kardan-Yamchi J, Amini S, Hamzelou G, Rahimi Foroushani A, Ghodousi A, et al.
…ction, a reduction of infectiousness, prevention of further resistance development and surveillance of drug-resistant TB. MTBDRsl VER 2.0 was used to detect resistance to second-line anti-tuberculosis drugs on 35 rifampicin-resistant M. tuberculosis (RR-MTB) isolates compared to …
Rajesh Kumar Yadav, Hari Prasad Kaphle, Dipendra Kumar Yadav, Suman Chandra Gurung, Elina Khatri, et al.
… is a major cause of treatment failure and the emergence of drug resistance among TB patients. The emergence of resistance to anti-tuberculosis drugs and particularly of multi-drug resistance (MDR), Pre-extensively drug resistance tuberculosis (Pre-XDR) and extensively drug resis…
…esearch and testing of Mycobacterium tuberculosis (MBT) for drug susceptibility in the Russian Federation is carried out with uneven qual-ity, which distorts the idea of primary drug resistance (DR). Aim. To study the primary DR of MBT to the main combinations of anti-TB drugs fo…
Zhang X, Chen X, Wang B, Fu L, Huo F, et al.
Aim: Fluoroquinolones (FQs) are the cornerstone in treating drug-resistant tuberculosis (TB); the prevalence of TB among the population is diverse in different regions, understanding the relationship between resistance pattern and molecular characteristic of FQs in preextensive d…
Zhdanova S, Jiao WW, Sinkov V, Khromova P, Solovieva N, et al.
This study aimed to determine phenotypic and genotypic drug resistance patterns of Mycobacterium tuberculosis strains from children with tuberculosis (TB) in China and Russia, two high-burden countries for multi/extensively-drug resistant (MDR/XDR) TB. Whole-genome sequencing dat…
Nurlan Takenov, Alibi Kaziyev, Asfendiyar Mukhamadi, Lyailya Chingissova, Bekzat Toxanbayeva, et al.
Tuberculosis, particularly multidrug-resistant TB (MDR-TB), remains a major public health concern in Kazakhstan, where 26% of new TB cases are MDR, far exceeding the global average. To better understand the genetic diversity, drug resistance, and transmission dynamics ofin Kazakh…
Tatiana Umpeleva, Kseniya Belousova, Ludmila Golubeva, Nataliya I. Eremeeva, Diana Vakhrusheva
…s patients in Russia. It has stronger association with multidrug resistance and possesses unique pathogenic properties. <b>Objectives:</b> To identify the spectrum of drug resistance mutations of MTB Beijing B0/W148 isolated from patient living in Ural Federal District of Russia.…
Breli Bonheur Ngouama, Jean Claude Djontu, Darrel Ornelle Elion Assiana, Freisnel Hermeland Mouzinga, Mita Naomie Merveille Dello, et al.
…CKGROUND:** WHO strategy to end Tuberculosis (TB) calls for drug susceptibility testing of Mycobacterium tuberculosis (MTB) for all patients, in high TB burden settings. Thus, this study aimed to investigate the MTB drug resistance profiles and related risk factors among patients…
Pinhata JMW, Brandao AP, Mendes FF, Rabello MCDS, Ferrazoli L, et al.
…ions in katG, inhA and rpoB genes, and isoniazid phenotypic resistance levels in Mycobacterium tuberculosis isolates from drug-resistant TB patients from São Paulo state, Brazil. Isolates resistant to the critical concentration of isoniazid in MGIT (0.1 µg/mL) were screened for m…