Showing 1–25 of 200 documents
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Prabha Desikan, Aseem Rangnekar, Nikita Panwalkar, Ram Prakash Punde, Sridhar Anand
Detection and treatment of drug resistance in extrapulmonary tuberculosis (EPTB) is a major challenge worldwide. Drug resistance in EPTB has not been studied extensively. However, patients with drug-resistant EPTB have been reported to have poor outcomes[1]. Rifampicin and isonia…
Wang T, Zhou C, Shang L, Zhou X
… positivity. However, there have been few reports of TB and drug resistance in this area. Methods We collected the demographic and clinical data of inpatients with sputum smear positive TB between 2015 and 2021 in an infectious disease hospital in the Liangshan Yi Autonomous Pref…
Bahram Nasr Esfahani, Sharareh Moghim, Mahshid Salehi, ShimaSadat Farzaneh, Marzieh Safari
…he genetic diversity and phylogenetic relationships of both drug-susceptible and drug-resistant Mycobacterium tuberculosis complex (MTBC) isolates with respect to first- and second-line anti-tuberculosis drugs using the 24-locus Mycobacterial interspersed repetitive units-variabl…
Varalakshmi Vummidi, Sekhar Talluri
…ulosis (TB) is a significant global health challenge due to drug resistance. Furthermore, tuberculous meningitis (TBM), which affects the central nervous system, has a particularly high mortality rate. TBM drugs have low efficacy because of their low blood-brain barrier (BBB) per…
Diriba G, Kebede A, Tola HH, Alemu A, Yenew B, et al.
…sts allow rapid detection of Mycobacterium tuberculosis and drug resistance in a few days. Identifying the mutations in genes associated with drug resistance may contribute to the development of appropriate interventions to improve tuberculosis control. So far, there is little in…
N Kusuma
…lth challenge, especially in immunocompromised individuals. Drug-resistant TB poses additional therapeutic obstacles, necessitating detailed case documentation and tailored treatment approaches. This case report presents a primary infection of drug-resistant laryngitis TB in an i…
K Mukanbaev, A. A. Turkmenov, A. A. Toktogonova, M. D. Kozhomkulov, Джун Чой Ен
…ction of molecular genetic and phenotypic rapid methods for drug susceptibility testing. Subjects and Methods. From 2018 to 2021, epidemiological surveillance forms for drug-resistant tuberculosis (DR TB) (TB 06, Table 3b for Results of Drug Susceptibility Testing to First- and S…
Andrey Zyubin, Anastasia I. Lavrova, Eugenie Postnicov, Marine Dogonadze, Elizaveta Demishkevich, et al.
The Mycobacterium tuberculosis (MbT) drug resistance remains a serious problem for global public health and usually leads to a lethal outcome. Precise and rapid identification of a specific MbT strain is vital for the appointment of antituberculosis therapy. We continue investiga…
Sanchit Mohan, Nupoor Vaghasia, Vishwanath Pujari, Priti Meshram
…f secondary ITP. Linezolid, despite being the backbone of a drug-resistant TB regimen, is the most common drug to cause thrombocytopenia in this subset of patients. Treatment of ITP requires immunosuppression with pulse steroids and intravenous immunoglobulin which can lead to di…
Doctor Busizwe Sibandze, Beki Themba Magazi, Lesibana Anthony Malinga, Nontuthuko Excellent Maningi, Bong Akee Shey, et al.
…is (EPTB). We investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tshwane metropolitan, South Africa. Methods Consecutive Mtb culture-positive non-pulmonary samples from unique EPTB patients underwent further myc…
Karol F Boschung, Patrick H P Wong, Denise Werry, Inna Sekirov, Shannon L Turvey, et al.
We report on 2 patients with drug-resistant tuberculous meningitis diagnosed and treated in a high-resource, low-incidence setting. Both patients were treated with multidrug regimens including bedaquiline, a nitroimidazole, cycloserine, and linezolid. Drug selection was informed …
Chernyaeva E, Rotkevich M, Krasheninnikova K, Lapidus A, Polev DE, et al.
…public health importance. Despite this, problems like early drug resistance, diagnostics and treatment success prediction are still not fully resolved. Here, we analyze the incidence of point mutations widely used for drug resistance detection in laboratory practice and conduct c…
Zina M.A. Alshami, Ahmed Mohammed Ali Alshammari, Ali N. Al-Awwady
…diseases that causes a significant rate of death worldwide. Drug-resistant Mycobacterium tuberculosis has been categorised into different categories according to its resistance type. Emergence of new noncategorized strains in the post-COVID-19 years among non-HIV-infected patient…
Jing Tong, Mengqiu Gao, Yu Chen, Jie Wang
…tion, low specimen content, and the increasing incidence of drug-resistant tuberculosis, which makes the accurate diagnosis and timely treatment of childhood tuberculosis face monumental challenges. Case presentation: The 14-year-old female, was admitted to the hospital with inte…
Zhanqiu Mao, Huilie Zheng, Zhenqiong Liu, Zanhua Li, Qilong Zhang
Drug-resistant tuberculosis (DR-TB) poses a critical public health challenge in Jiangxi Province, China, where regional resistance patterns remain understudied. This retrospective study analyzed 9,041 suspected TB patients (2022-2023), identifying 3,104() casesPCR-reverse blot hy…
Paolo Miotto, Francesca Saluzzo, Andrea M Cabibbe, Daniela M Cirillo
…te and timely diagnosis of active tuberculosis (TB) and its drug-resistant forms are essential for effective patient care and global TB disease control. This paper summarizes the latest advances in TB disease diagnostics. We describe mechanisms of drug resistance in, including bo…
Sibandze DB, Magazi BT, Malinga LA, Maningi NE, Shey BA, et al.
…TB). Here, we investigated Mycobacterium tuberculosis (Mtb) drug resistance and transmission patterns in EPTB patients treated in the Tshwane metropolitan area, in South Africa. Methods Consecutive Mtb culture-positive non-pulmonary samples from unique EPTB patients underwent myc…
Anastasia I. Lavrova, Andrey Zyubin, Marine Dogonadze, Evgenii Borisov, Ilia Samusev, et al.
…argue that the SERS technique allows distinguishing between drug-sensitive and drug-resistant strains on the level of resolution of individual mycobacteria. This result is based on the experimental investigations of deactivated M. tuberculosis strains by the Raman spectroscopy in…
Ma L, Gao M
…To analyze the clinical characteristics and risk factors of drug resistance of newly-treated chronic obstructive pulmonary disease (COPD) complicated pulmonary tuberculosis (PTB). Methods A total of 489 newly-treated PTB patients admitted to Beijing Geriatric hospital were retros…
Mahmoud M. Tawfick, Mona Shaban E. M. Badawy, Mohammed Taleb, Nagwan G. El Menofy
…cation strategy is hampered by the global health concern of drug-resistant (DR) TB. Effective patient treatment, preventing TB transfer and avoiding the upsurge of DR strains depend primarily on the timely and accurate identification of DR TB. Due to inadequate sensitivity, the n…
Herikurniawan Herikurniawan, Joanna Audrey, Mira Yulianti, N Indira, Cleopas Martin Rumende
…lungs but also the extrapulmonary organs. The prevalence of drug-resistant tuberculosis (DR-TB) is rising and has caused a higher mortality rate than drug-susceptible tuberculosis (DS-TB). This article presents a patient with a rare co-infection of pulmonary DS-TB and pleural DR-…
Yuejiao Liu, Runrui Wu, Junjun Liu, Jinlong Dai, Dongxu Liu, et al.
…understanding the distinct pathological characteristics and drug resistance patterns of CTB, a subject that has not been extensively explored previously. In this study, we conducted a comparative analysis of 59 CTB samples and 59 pulmonary tuberculosis samples, focusing on their …
Radha Gopalaswamy, Azger Dusthackeer, Silambuchelvi Kannayan, Selvakumar Subbian
…cies. While EPTB due to MTBC responds to first-line anti-TB drugs (ATD), drug susceptibility profiling is an essential criterion for addressing drug-resistant EPTB cases (DR-EPTB). Besides antibiotics, adjuvant therapy with corticosteroids has also been used to treat specific EPT…
Nuwagira E, Yekosani M, Abraham B, Atwine R, Caleb T, et al.
Background Extrapulmonary drug-resistant tuberculosis is extremely rare and is almost always associated with poor treatment outcomes. This is partly due to the difficulty in confirming the diagnosis. Case presentation A 40-year-old HIV-negative male presented with a painless scro…
Santana Clarissa Cunha, Silva Camila Santos, Silva Paula Rocha Dantas, Mota Scarlet Torres Moraes, Barbosa Theolis, et al.
…world challenge due to its high burden and the emergency of drug-resistant MTB. MTB employs a wide range of resistance mechanisms to escape the action of the drugs currently in use for TB treatment. These mechanisms can be classified as intrinsic or acquired and are related to my…