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Khan A, Singh VK, Mishra A, Soudani E, Bakhru P, et al.
…ople each year and the widely used Bacille Calmette-Guérin (BCG) vaccine provides a partial protection against TB in children and adults. Because BCG vaccine evades lysosomal fusion in antigen presenting cells (APCs), leading to an inefficient production of peptides and antigen p…
Ghasemi F, Kardan-Yamchi J, Heidary M, Karami-Zarandi M, Akrami S, et al.
…global tuberculosis (TB) epidemic. Bacille Calmette-Guérin (BCG), the only currently approved TB vaccine, is successful in preventing disseminated disease in newborns. However, it has a variable efficacy against pulmonary TB in adults. This protective effect of the vaccine varies…
Woo Joo Kim, M.D, Ph.D
Healthy adults will be once administered GC3107(BCG Vaccine) Intradermally. Healthy adults will be once administered GC3107(BCG Vaccine) Intradermally. Tuberculin Skin Test(TST) will be conducted after 84+7 days after IP injection and TST result will be read in 48\~72 hours.
Erum Siddiqui, Mohammad Saad Khan, Maliha Khalid, Harshika Khaim Chandani, Umaimah Naeem, et al.
… a significant threat to global public health. Although the BCG vaccine, developed in the 1920s, remains the only approved TB vaccine, it has limited efficacy, particularly against pulmonary TB in adults. The ID93/GLA-SE vaccine, a recombinant subunit vaccine, shows promise by tr…
Qiuyao Zhan, Liang Zhou, Jianbo Fu, Xun Jiang, Xuan Liu, et al.
Vaccines are a cornerstone of global public health, but their efficacy can vary significantly among individuals. Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is one of the most used vaccines, and its efficacy is influenced by numerous factors, including sex, ag…
Penn-Nicholson A, Tameris M, Smit E, Day TA, Musvosvi M, et al.
Background A vaccine that prevents pulmonary tuberculosis in adults is needed to halt transmission in endemic regions. This trial aimed to assess the safety and immunogenicity of three administrations at varying doses of antigen and adjuvant of an investigational vaccine (ID93 + …
Singh DK, Dwivedi VP, Singh SP, Kumari A, Sharma SK, et al.
…infected and ~2 million deaths annually. The only available vaccine for TB, Bacillus Calmette Guérin (BCG), is ineffective against adult pulmonary TB. Therefore, alternate strategies that enhance vaccine efficacy are urgently needed. Vaccine efficacy and long-term immune memory a…
Moorlag SJCFM, Taks E, Ten Doesschate T, van der Vaart TW, Janssen AB, et al.
…uding coronavirus disease 2019 (COVID-19). The tuberculosis BCG vaccine may provide heterologous protection against nontuberculous infections and has been proposed as a potential preventive strategy against COVID-19. Methods In this multicenter, placebo-controlled trial, we rando…
Ramon Andrade de Souza, Florisneide Rodrigues Barreto, Carla Cristina Oliveira de Jesus Lima, Marcio Santos da Natividade, Carlos Antônio de Souza Teles Santos, et al.
…rin prevent clinical progression of COVID-19? Data from the BCG-REVAC trial was archived in a database, creating an excellent opportunity to link it to notified cases of COVID-19 to evaluate the efficacy of BCG against incidence, severity and clinical progression to severe COVID-…
Arrieta-Villegas C, Allepuz A, Grasa M, Martín M, Cervera Z, et al.
… infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated wit…
Mark F. Cotton, Helena Rabie
… control through vaccination remains a global priority. The efficacy of BCG given to neonates to prevent tuberculosis meningitis and miliary tuberculosis is well known.1Trunz BB Fine P Dye C Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis wo…
Tameris M, Mearns H, Penn-Nicholson A, Gregg Y, Bilek N, et al.
…nd Infants are a key target population for new tuberculosis vaccines. We assessed the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmission of tuberculosis is very high. Methods We…
Helen McShane
This is a human pilot study of 16 healthy BCG-naïve volunteers to quantify BCG from the BCG vaccination site. Volunteers will be vaccinated with BCG. The first 8 will go on to have a punch biopsy and suction blister of the vaccination sites at 2 weeks post vaccination (arm A) the…
Dhiraj K Singh, Peter Um, Garima Arora, Xavier Alvarez, Vinay Shivanna, et al.
…h due to infection globally. Bacillus Calmette Guérin (BCG), a live attenuated bacterial strain, is the only available TB vaccine, but it has poor efficacy in preventing pulmonary TB in adults. There are advantages associated with the BCG platform however, including a remark…
Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, et al.
Abstract The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased i…
Sarfas C, White AD, Sibley L, Morrison AL, Gullick J, et al.
…tuberculosis (TB) is endemic, the Bacillus Calmette-Guérin (BCG) vaccine is given as close to birth as possible to protect infants and children from severe forms of TB. However, BCG has variable efficacy and is not as effective against adult pulmonary TB. At present, most animal …
Ahmad S, Bhattacharya D, Kar S, Ranganathan A, Van Kaer L, et al.
…ly worldwide. Mycobacterium bovis bacillus Calmette-Guérin (BCG), the only TB vaccine in common use, is effective against disseminated and meningeal TB in young children but is not effective against adult pulmonary TB. T helper 1 (Th1) cells producing interferon gamma (IFN-γ) and…
Chen YQ, Cao SH, Yang XY, Liu Y, Li CY
Background The current prophylactic tuberculosis vaccine Bacille Calmette-Guérin (BCG), was derived in the 1920s, but the humoral immune responses induced by BCG vaccination have not been fully elucidated to date. In this study, our aim was to reveal the profiles of antibody resp…
Mark F. Cotton, Helena Rabie
…lth Organization, Geneva2015Google Scholar and an effective vaccine was a key component of this strategy. Although tuberculosis vaccine research began in earnest in the 1990s, a strategic blueprint for tuberculosis vaccine development beyond the BCG vaccine was released in 2012. …
Wenping Gong, Jianping Xie, Hao Li, Ashok Aspatwar
…/tuberculosis). However, it is reported that the protective efficacy of BCG is highly variable and ranges between 0% and 80%, and its protection lasts only for 10 to 15 years [2]. Therefore, developing a new effective TB vaccine is pressing and challenging for governments and sci…
Ahmed M. Abbas, Asmaa Abou‐Bakr, Nermeen Bahaa, Sherry Michael, Marco Ghobrial, et al.
… relationship between COVID-19 and Bacille Calmette Guérin (BCG) vaccine is still under investigation, and we aim to clarify this matter. Bacille Calmette Guérin is a live attenuated tuberculosis vaccine. BCG vaccination of adult humans induces strained circulating monocytes havi…
Wilkie MEM
…means there is a desperate need for a safe and effective TB vaccine. BCG is the only licensed vaccine and extremely variable in efficacy. However, BCG potentially exerts a non-specific beneficial effect - protecting infants from other causes of death such as respiratory infection…
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
de Gijsel D, von Reyn CF
Objectives The efficacy of childhood BCG vaccination in the prevention of adult pulmonary tuberculosis is not universally accepted. Methods We reviewed the published literature and summarized studies of BCG vaccination reporting long-term protection against pulmonary TB. Results …
Bitencourt J, Peralta-Álvarez MP, Wilkie M, Jacobs A, Wright D, et al.
…major global health problem and the only currently-licensed vaccine, BCG, is inadequate. Many TB vaccine candidates are designed to be given as a boost to BCG; an understanding of the BCG-induced immune response is therefore critical, and the opportunity to relate this to circums…