Showing 176–200 of 200 documents
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Sophia B Georghiou, Nestani Tukvadze, Camilla Rodrigues, Shaheed Vally Omar, Andrea Maurizio Cabibbe, et al.
**INTRODUCTION:** Early and accurate diagnosis of drug-resistant tuberculosis (DR-TB) is essential for improving treatment outcomes. Phenotypic drug susceptibility testing (pDST) is comprehensive but slow, while rapid molecular assays provide resistance information for a limited …
Mahmoud M, Tan Y
… several anti-TB,TB infection continues to increase. Global resistance to TB remains the greatest challenge. There has not been extensive research into a new treatment and management strategy for TB resistance therapy. This review is based on a review of new advances and alternat…
Richa Singh, Devendra Singh Chauhan, Tulika Prasad
…ts for 1.2 million deaths annually worldwide. First line of drugs used for treatment of TB includes rifampicin, isoniazid, ethambutol and streptomycin; these are bactericidal, less toxic and highly efficient. Outbreak of multidrug resistant (MDR) strains complicates the effective…
Shulin Song, Donghui Gan, Di Wu, Ting Li, Shiqian Zhang, et al.
The issue of multi-drug-resistant tuberculosis (MDR-TB) presents a substantial challenge to global public health. Regrettably, the diagnosis of drug-resistant tuberculosis (DR-TB) frequently necessitates an extended period or more extensive laboratory resources. The swift identif…
Le X, Qian X, Liu L, Sun J, Song W, et al.
Trends in and risk factors for drug resistance in Mycobacterium tuberculosis ( M. tuberculosis ) in human immunodeficiency virus (HIV)-infected patients with active tuberculosis were analyzed. The clinical data of M. tuberculosis and HIV-coinfected patients treated at the Shangha…
Yazısız H, Hırçın Cenger D, Yazısız V, Kılıç L, Altın S
…portant public health problem in the undeveloped countries. Drug sensitivity rate should be monitored for the effective treatment and control in the TB. The aim of this study was to determine the rate of resistance to first line TB drugs in the Mycobacterium tuberculosis complex …
Chukwuemeka Anthonia
…ountries with a high burden of Tuberculosis (TB) worldwide. Drug-resistant TB is a global health burden, but disproportionately higher among TB patients in resource-constrained countries like Nigeria. We described the pattern of resistance to first-line anti-TB drugs among patien…
K K Bhattacharyya, Vishal Nemaysh, Monika Joon, Ramendra Pratap, Mandira Varma‐Basil, et al.
Additional file 2. Complete list of Non-Synonymous SNV in VPCI591.
McNerney R, Zignol M, Clark TG
Introduction The threat of resistance to anti-tuberculosis drugs is of global concern. Current efforts to monitor resistance rely on phenotypic testing where cultured bacteria are exposed to critical concentrations of the drugs. Capacity for such testing is low in TB endemic coun…
World Health Organization, WHO/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance
E.V. Bulycheva, V. V. Bulychev, Elena N. Velichko, Nataya A. Pashkova
BACKGROUND: Drug resistance to anti-tuberculosis drugs directly affects the disease course. However, a high percentage of multidrug resistance in patients with HIV infection not only worsens the disease course but also forces the development of new strategies for managing such pa…
Htin Lin Aung, Lidya Chaidir, Dian Ayu Eka Pitaloka, Yugen Miyahara, Narender Kumar, et al.
**OBJECTIVE:** This study evaluated drug resistance profiles of Mycobacterium tuberculosis (Mtb) isolates in West Java, Indonesia through phenotypic and genomic approaches. **METHODS:** We performed phenotypic drug-susceptibility testing (DST), coupled with whole-genome sequenci…
Xu K, Wang S, Wu J, Liu Z, Ji Z, et al.
…stic performance of the Biochip system for the detection of drug-resistant tuberculosis using smear-positive sputum specimens. This prospective study evaluated the diagnostic performance of this new platform for drug resistant and multidrug-resistant tuberculosis (MDR-TB) using 1…
Seid A, Girma Y, Dereb E, Kassa M, Nureddin S, et al.
…study was to determine the in vitro susceptibility level of drugs and drug interaction profiles against drug-resistant and susceptible M. tuberculosis clinical isolates. A laboratory-based cross-sectional study was conducted between January 2023 and August 2023. GenoType MTBDRplu…
Nikhil Sarangdhar, K C Mohanty
…nd improvement in patients of pulmonary and extra-pulmonary drug-resistant (DR) [including Multi-drug resistant (MDR) and Extensively-drug resistant(XDR)] TB receiving Levamisole along with anti-TB drug therapy and observe the safety profile of levamisole. <b>Methods:</b> In this…
Pečerska J, Kühnert D, Meehan CJ, Coscollá M, de Jong BC, et al.
As multi-drug resistant tuberculosis (MDR-TB) continues to spread, investigating the transmission potential of different drug-resistant strains becomes an ever more pressing topic in public health. While phylogenetic and transmission tree inferences provide valuable insight into …
Mary A. Alex- Wele, Nneka Onyejepu, Orikomaba Obunge
…essed persons, with a high mortality rate. The emergence of drug-resistant variants of TB further weighted down by the high HIV prevalence continues to make it difficult to treat this disease. Nigeria is currently listed among the 30 high burden countries for TB, TB/HIV and drug …
M Park, Giovanni Satta, Onn Min Kon
<b>Background:</b> With growing concerns for drug resistant TB especially isoniazid (INH) resistance, early identification of TB and drug susceptibilities are essential. WGS still requires culture before availability of drug susceptibilities, taking weeks. Xpert MTB/XDR (Cepheid,…
Rodney Dawson
…ical trial in four parallel treatment groups. Subjects with drug-sensitive tuberculosis (DS-TB) will be randomized to receive either J(loading dose/three times a week)PaZ; or J(200mg)PaZ; or HRZE. Subjects with multi drug-resistant tuberculosis will receive J(200mg)MPaZ. The HRZE…
Hansraj Choudhary, Garima Malik, Devendra Singh Chauhan, Manpreet Bhalla, Azger Dusthackeer, et al.
… Elimination Programme (NTEP) do not detect isoniazid (INH) resistance upfront. PathoDetect™ MTB RIF & INH is an indigenous closed-system assay that simultaneously detects Mycobacterium tuberculosis (MTB) and resistance to rifampicin (RIF) and INH. This study evaluated its…
Sufang Wu, Lulu Ge, Shulan Zheng, Xiaocui Ma, Ruixia Liang, et al.
… of MassARRAY technology for detecting(MTB) and identifying drug resistance, compared to traditional culture methods and Xpert MTB/RIF. From July 2021 to February 2024, bronchoalveolar lavage fluid (BALF) samples from 289 suspected pulmonary tuberculosis patients at Henan Provinc…
Zignol M, Cabibbe AM, Dean AS, Glaziou P, Alikhanova N, et al.
…d In many countries, regular monitoring of the emergence of resistance to anti-tuberculosis drugs is hampered by the limitations of phenotypic testing for drug susceptibility. We therefore evaluated the use of genetic sequencing for surveillance of drug resistance in tuberculosis…
Evans EE, Avaliani T, Gujabidze M, Bakuradze T, Kipiani M, et al.
Background Little is known about the impact of drug-resistance on clinical outcomes among patients with tuberculosis meningitis (TBM). Methods A retrospective cohort study among patients treated for TBM in Tbilisi, Georgia. We performed medical chart abstraction to collect patien…
Bedaso MH, Kalil FS
…piaTel +251 923728803Email direhasen@gmail.comPurpose: Multidrug-resistant tuberculosis threatens global tuberculosis care and prevention and remains a major public health concern in many countries. In 2016, there were an estimated 490,000 cases of MDR and 110,000 more cases resi…
Qianyun Zhou, Li Zhang, Mei Zhou, Lang Xiao, Niannian Liu, et al.
Drug-resistant tuberculosis (TB) lacks rapid blood-based biomarkers. This study examined whether serum levels of ankyrin repeat domain 22 (ANKRD22) and serpin family G member 1 (SERPING1) are associated with drug resistance in TB patients. In this retrospective cross-sectional st…