Showing 176–200 of 200 documents
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Aisya Rezki Noeriman, Sumarheni Sumarheni, Aliya Nur Hasanah, Lika Apriani, Prayudi Santoso, et al.
**BACKGROUND:** Therapeutic drug monitoring (TDM) is a tool used for dose optimization to achieve therapeutic concentrations associated with improved outcomes. However, evidence supporting its benefits for tuberculosis (TB) treatment remains limited. This scoping review evaluated…
Suraj B. Sable, Wen Li, Allison Kline, Sakthivel Govindaraj, Vijayakumar Velu, et al.
…rapies (HDT) represent a pivotal strategy in combating both drug-susceptible and drug-resistant tuberculosis (TB). Current evaluations, however, show limited success in animal models and clinical settings, emphasizing the need for more effective HDT candidates. With few druggable…
Rebecca Thomas, Nicola L Harman, Paula R Williamson, Laura Bonnett, Geraint R Davies, et al.
…en of tuberculosis (TB) remains high, and treatment of both drug-susceptible and drug-resistant diseases is complex and prolonged. International clinical trial networks and public-private partnerships are beginning to deliver advances in TB treatment, and collaborative data-shari…
H S Schaaf, D T Wademan, L E van der Laan
…developing child-friendly antituberculosis formulations for drug-susceptible and drug-resistant TB, a single-medicine rifampicin dispersible tablet is still needed. Further, many child-friendly dispersible solid-tablet formulations are not available globally. Access challenges le…
Sarah Schmidiger, Damien Portevin
…. Improved vaccines, diagnostics and treatment regimens for drug-susceptible and drug-resistant cases are paramount to attain the goals of the WHO's End TB Strategy. Our knowledge gap in protective immunity in TB impedes the development of such new vaccines and host-directed inte…
Mukunda Prasad Kafle
…ts on dialysis may be up to 10 times the risk. Furthermore, drug metabolism and excretion is also abnormal in this situation. Ethambutol and pyrazinamide are excreted by the kidneys. Therefore, if failed kidneys can’t adequately remove the drugs, accumulation to toxic levels migh…
Cesilia C, Rinawan FR, Santoso P, Nataprawira HM
…try and echocardiography results in adolescent survivors of drug-susceptible (DS) and drug-resistant (DR) pulmonary TB (PTB). Methods This retrospective cohort study was conducted in 52 adolescent PTB survivors. We compared persistent clinical symptoms, CXR, spirometry and echoca…
Hendra Subroto, Ida Parwati, Bachti Alisjahbana, Coriejati Rita, Yuhpita Indah Efriyani, et al.
…collected from 39 patients with active TB (26 patients with drug-resistant and 13 patients with drug-sensitive tuberculosis) and 34 healthy adults (73 total individuals). Thirty-nine patients who met the inclusion criteria were followed up until completion of TB treatment. There …
Lena Faust
…rtant context for Manuscript 2, in which we constructed the drug-susceptible (DS) and drug-resistant (DR)TB care cascades prior to and during COVID-19 in Lima province, Peru. We also collected data from patient registries of n=1,513 people receiving TB care in a district of Lima …
Liu Y, Moodley M, Pasipanodya JG, Gumbo T
…andard in guiding individual patient therapy as well as for drug resistance surveillance. However, for most antituberculosis drugs, breakpoints are instead defined by the epidemiological cutoff values of the MIC of phenotypically wild-type strains irrespective of PK/PD or dose. I…
Zhang W, Lun S, Liu LL, Xiao S, Duan G, et al.
…ssess excellent anti-tuberculosis activity against both the drug-susceptible (MIC = 0.0039 μg/mL) and drug-resistant Mtb strains (MIC = 0.0078 μg/mL). Moreover, the excellent in vitro activity is translated to the in vivo mouse serum inhibitory titration assay, with administratio…
Catherine Vilchèze
…s after the introduction of the first antituberculosis (TB) drug, the treatment of drug-susceptible TB remains very cumbersome, requiring the use of four drugs (isoniazid, rifampicin, ethambutol and pyrazinamide) for two months followed by four months on isoniazid and rifampicin.…
Kohler S, Achar J, Mulder C, Sitali N, Paul N
Background The Global Drug Facility (GDF) of the Stop TB Partnership was launched in 2001 with the goal of increasing access to quality-assured tuberculosis (TB) drugs and products. We aimed to describe the TB drugs and prices available from the GDF over time and to assess trends…
Stephanie Law, Annabel Baddeley, Anna Carlqvist, Farai Mavhunga, Kerri Viney, et al.
…TS:** Participants (n=24, 13 women) were treated for drug-susceptible (n=13) or drug-resistant (n=11) TB between 2015 and 2021. They faced diverse comorbidities (mental health and substance use disorders, diabetes, Hepatitis C, lupus and HIV); half of whom reported more th…
Alatise MA, Narasimhan P, Gbadamosi MD, Chughtai AA
…h Tuberculosis burden globally. The increasing incidence of drug resistance following poor treatment adherence among drug-susceptible TB (DS-TB) patients necessitates reviewing TB services in Nigeria. This study explored accessibility and patient-reported experiences in newly est…
Collins Timire, Mkhokheli Ngwenya, Joconiah Chirenda, John Metcalfe, Katharina Kranzer, et al.
…uster sampling among TB patients. We enrolled patients with drug susceptible (DS-TB) and drug resistant TB (DR-TB) consecutively. We administered a standardised questionnaire to capture the costs incurred as well as lost income due to TB illness. Catastrophic costs were measured …
Widoyo R, Djafri D, Putri ASE, Yani FF, Kusumawati RL, et al.
This study aimed to assess the percentage of confirmed drug-sensitive (DS) TB and drug-resistant (DR) TB patients who were missing in the national treatment registration in North Sumatra and West Sumatra, where treatment services for DR-TB in North Sumatra are relatively well est…
Moe S, Asozoda M, Aung A, Dusmatova Z, Akintore F, et al.
…nings were conducted, identifying 31 TB cases, including 17 drug-susceptible TB cases, eight drug-resistant TB cases, and six clinically diagnosed cases. The overall screening yield was 0.43%. Notably, the screening yield was 3.4% among individuals with at least one TB symptom an…
Toua W, Lape V, Bolnga JW, Daimen M, Kelebi T, et al.
…OR 2.82 compared to HIV-negative; 95% CI 2.39-3.33), having drug-resistant TB (aOR 3.26 compared to drug-susceptible TB, 95% CI 1.18-9.00), and travel time to the health facility 1- Conclusion High LTFU from TB treatment was associated with factors that indicate barriers to acces…
Eric Nuermberger, MD
…IV (PLHIV) and high-risk Close Contacts (CC) of adults with Drug Susceptible (DS) or Rifampin Resistant (RR) TB. Treating adult, adolescent, child, and pregnant close contacts (CCs) of drug-sensitive tuberculosis (DS-TB) who are high-risk for developing tuberculosis disease (TBD…
National Institute of Allergy and Infectious Diseases (NIAID)
…s, ages 18-60. Participants will be treated with 4 standard drugs called isoniazid, rifampicin, pyrazinamide and ethambutol. All individuals will take TB medicines for at least 4 months. After 4 months of treatment, if no TB germs are growing in sputum samples, participants will …
Tudó G, Lopez-Gavin A, Portell-Buj E, Freixes J, Vila J, et al.
…acterium tuberculosis isolates. Eleven OFX-resistant and 11 drug-susceptible clinical isolates were studied. Individual minimum inhibitory concentrations of OFX, LFX, MOX, and UB-8902 were determined using Middlebrook 7H11 agar. The concentrations studied ranged from 0.125 to 128…
Safi H, Gopal P, Lingaraju S, Ma S, Levine C, et al.
… as the propensity of Mycobacterium tuberculosis to develop drug resistance, are major barriers to global TB control efforts. M. tuberculosis is known to have the ability to enter into a drug-tolerant state, which may explain many of these impediments to TB treatment. We have ide…
S TP, Bommahalli Jayaraman B, Siddiqui MK
…o prevent transmission. However, ongoing challenges include drug-resistant strains and socioeconomic factors influencing its prevalence. Drugs such as isoniazid, pyrazinamide, ethambutol, ethionamide, linezolid, and levofloxacin are approved for the treatment of drug-susceptible …
Shamsuddeen Yusuf Ma'aruf, Aparna Sharma, Shannon Fox, Raquel Duarte, Christoph Lange, et al.
…orted in 2023. While treatment is generally effective, both drug-susceptible (DS-TB) and drug-resistant TB (DR-TB) regimens are associated with adverse events (AEs) that compromise adherence and outcomes. In this viewpoint, we highlight the most clinically relevant AEs: hepatotox…