Showing 176–200 of 200 documents
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Karthick Vedi, N Venkateswaramurthy, P. Dineshkumar, Satheesh Nagendrans
…XDR-TB), poses major global health challenges. Conventional regimens achieve only 50-60% success rates compared to 85% in drug-susceptible TB. This review examines recent therapeutic advances in drug-resistant TB management, focusing on novel and repurposed agents, their mechanis…
Vanino E, Granozzi B, Akkerman OW, Munoz-Torrico M, Palmieri F, et al.
…is recommended in place of the 9-month or longer (18-month) regimens in MDR/RR-TB patients, now including extensive pulmonary TB and extrapulmonary TB (except TB involving central nervous system, miliary TB and osteoarticular TB); (ii) the use of the 9-month all-oral regimen rath…
Singh B, Cocker D, Ryan H, Sloan DJ
… of linezolid as a component of drug-resistant TB treatment regimens.
SushantSatish Mane
…able under NTEP in dispersable forms, which have simplified regimens of DSTB in children; also eliminating the risk of missing a particular drug from treatment. As there is a 12%–15% background resistance only to isoniazid in India, ethambutol is added as the third drug along wit…
Mongia H, Mamnoon F, Silsarma A, Mahajan R, Dalal A, et al.
…t bedaquiline-delamanid (BDQ-DLM) as part of individualised regimens for eligible patients with pulmonary drug-resistant tuberculosis (DR-TB); however, data for patients with drug-resistant extrapulmonary tuberculosis (EPTB) is extremely limited. This study documents the treatmen…
Lee SFK, Laughon BE, McHugh TD, Lipman M
…n general requires good adherence to potentially toxic drug regimens over prolonged periods. Poor adherence is associated with resistance development and poor outcome. This review will present promising new treatments, both new drugs and regimens, for difficult mycobacterial pulm…
Elwira Sieniawska
…(amikacin, kanamycin, capreomycin) used in MDR-TB treatment regimens. In the era of global population movements, the emergence of MDR-TB and XDR-TB makes the fight against tuberculosis an ongoing challenge (World Health Organization, Global Tuberculosis Report, 2019). Current tre…
Heyckendorf J, Andres S, Köser CU, Olaru ID, Schön T, et al.
…0 MGIT or Löwenstein-Jensen to construct M/XDR-TB treatment regimens for a cohort of 25 consecutive M/XDR-TB patients and 15 possible anti-TB drugs. Genotypic DST results from Cepheid GeneXpert MTB/RIF (Xpert) and line probe assays (LPAs; Hain GenoType MTBDR plus 2.0 and MTBDR sl…
Misra N, Padayatchi N, Naidoo P
Background Optimal drug levels and minimal toxicity are critical factors in improving treatment outcomes for patients' prescribed new and repurposed medicine for drug-resistant (DR) tuberculosis (TB). The optimal dose of clofazimine (CFZ), a repurposed medicine for DR-TB, that is…
Pitso L, Potgieter S, Van der Spoel van Dijk A
Background Multidrug- and extensively drug-resistant tuberculosis (MDR-TB and XDR- TB) threaten local and global control of the disease. The molecular line-probe assay (LPA) provides rapid diagnosis and early management of MDR-TB. The LPA detects mutations of katG and inhA genes …
L.I. Rusakova, Daria Kucheryavaya, Tamara Izmailova
… 28.0% in 2020. The treatment success rate for chemotherapy regimens 1, 2, and 3 decreased from 69.0% in 2017 to 66.0% in 2020, which produced a negative impact on the indicative rate of treatment success for all TB cases (r = 0.99; p < 0.05). There was persistent growth in th…
Russkikh A, Korotych O, Sereda Y, Samoilova A, Achar J, et al.
…patients may serve as a basis for optimization of treatment regimens. We conducted a retrospective cohort study using health records from 54 patients with pulmonary XDR-TB treated at a tertiary level facility in the Russian Federation. The study population included adult patients…
Pontali E, Visca D, Centis R, D'Ambrosio L, Spanevello A, et al.
…etter position these drugs. Recent information on treatment regimens for the paediatric age, with or without delamanid or bedaquiline, has become available. This is of great help in designing safer and more efficacious regimens for the treatment of MDR/XDR-TB in children and adol…
Sarmat Z. Suleimanov, М. В. Синицын
Objective: to assess the effectiveness of chemotherapy regimens for multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) with the inclusion of linezolid (Lzd) and bedaquiline (Bq) in patients who underwent a surgery for pulmonary TB. Mate…
Gizachew Taddesse Akalu, Belay Tessema, Waganeh Sinshaw, Misikir Amare, Getu Diriba, et al.
…) of isolates were resistant to all first-line anti-TB drug regimens. Interestingly, all isolates were susceptible to all recently recommended second-line anti-TB drugs, and none of these isolates were found to be pre-XDR or XDR-TB. The rate of RR-TB detected was 10.9% (17/156) a…
James CM Brust, MD, Gary Maartens, MBChB
…ly drug-resistant tuberculosis (XDR) tuberculosis treatment regimens include linezolid. When given long-term, however, linezolid-associated toxicity-particularly myelosuppression and peripheral neuropathy-is very common, affecting 50-80% of patients and often requiring a temporar…
Singh V, Chibale K, Chibale K
…stance can be managed by accurate diagnosis and tailor-made regimens. "Antimicrobial resistance (AMR), is one of the most paramount health perils that has emerged in the 21st century. The global increase in drug-resistant strains of various bacterial pathogens prompted the World …
Anjali Krishnan P, Praveen Kumar N, Raghul Raj S, Ankit Kumar Bharti S, J. A. Pulatov
…TB Control Program. Results: Among 163 patients, short-term regimens were used in 30 patients (18.2%), including m-STTR (8.5%), m-STTR with delamanide (1.2%), and 6-month BPaLM (8.5%). Long-term standard regimens were used in 53 patients (32.5%). For XDR-TB, BPaL and BPaLC were u…
Li Z, Liu F, Chen H, Han Y, You Y, et al.
…tistically analysed, including demographic characteristics, regimens, and outcomes. Results Of the 3689 Mycobacterium tuberculosis strains, 639 (17.32%), 353 (9.56%), and 109 (2.95%), multidrug-resistant tuberculosis (MDR-TB), pre-extensively drug-resistant tuberculosis (pre-XDR)…
Fekadu G, Yao J, You JHS
…eatment success rate of conventional anti-tuberculosis (TB) regimens for extensively drug-resistant TB (XDR-TB) is low, resulting in high morbidity and healthcare cost especially in the high TB burden countries. Recent clinical findings reported improved treatment outcomes of XDR…
Dr SM Khan
…t of treatment received, prior receipt of number of anti-TB regimens and comorbid illnesses and adverse drug reactions. Males outnumbered the females, residents of Nagpur district (urban and rural areas) were found to be more than other districts of Vidarbha region. One patient o…
Gomez GB, Siapka M, Conradie F, Ndjeka N, Garfin AMC, et al.
Objectives Patients with highly resistant tuberculosis have few treatment options. Bedaquiline, pretomanid and linezolid regimen (BPaL) is a new regimen shown to have favourable outcomes after six months. We present an economic evaluation of introducing BPaL against the extensive…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
… easier-to-administer, and more patient-tolerable treatment regimens [[2]WHO consolidated guidelines on tuberculosis. Module 4: treatment - drug-resistant tuberculosis treatment, 2022 update. https://www.who.int/publications/i/item/9789240063129 - accessed 3 April, 2023Google Sch…
Eric R Houpt, MD
…rk will inform future diagnostic strategies and therapeutic regimens. The multidrug-resistant tuberculosis (MDR-TB) epidemic in the Irkutsk oblast of Eastern Siberia is arguably the most severe in the world. The investigators have found that in the Irkutsk TB Dispensary, the ref…
Sarmat Z. Suleimanov, М. В. Синицын
…e-extensively drug-resistant tuberculosis (ТВ) chemotherapy regimens with the inclusion of linezolid (Lzd) and bedaquiline (Bq) in operated patients for pulmonary ТВ. Material and methods. A non-randomized continuous single-center retrospective study of the data of 154 patients o…