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Scott NA, Sadowski C, Vernon A, Arevalo B, Beer K, et al.
Background Treatment completion is essential for the effectiveness of any latent tuberculosis infection (LTBI) regimen. The Tuberculosis Trials Consortium (TBTC) Study 33 (iAdhere) combined self-report and pill counts - standard of care (SOC) with a medication event monitoring sy…
Sharma N, Bakshi R, Basu S, Zode M, Arora R, et al.
Objective The primary objective of this study was to ascertain the acceptance, initiation, implementation and treatment completion rates of tuberculosis (TB) preventive therapy (TPT) using 3HP (INH-Rifapentine) among household contacts of microbiologically confirmed drug sensitiv…
Mehtani NJ, Puryear S, Pham P, Dooley KE, Shah M
…ntiretroviral therapy (ART). However, newer rifamycin-based regimens are safer, shorter in duration, associated with improved adherence, and may be as or more effective than isoniazid TPT. Current guidelines have significant heterogeneity in their recommendations for TPT regimens…
Jung YEG, Schluger NW
…o active disease; and the development of novel short-course regimens for treatment of latent tuberculosis. Recent findings As many as one-third of the world's population has latent infection with Mycobacterium tuberculosis. Models demonstrate that tuberculosis will not be elimina…
Swain S, Kumar A, Vishwakarma VK, Aayilliath K A, Mittal A, et al.
…ith effective strategies targeting LTBI. Multiple treatment regimens have been approved for LTBI treatment, and all have comparable efficacy. The selection of one regimen over the other depends on various factors, such as availability, risk of adverse events, age, and drug intera…
Suliman AM, Bek SA, Elkhatim MS, Husain AA, Mismar AY, et al.
Immune checkpoint inhibitors (ICIs)-anti-programmed death-1 (PD-1) and their ligands (PD-L1 and PD-L2) have become widely used in the treatment of several malignancies. Many immune-related adverse events (irAEs) have been linked to these agents. Nonetheless, tuberculosis (TB) rea…
Yi‐Ping Phoebe Chen, Frederick L. Altice, Divya Ghoshal, Ahsan Ahmad, Jiang Long, et al.
Abstract Tuberculosis (TB) is a major health threat worldwide. TB is concentrated in prisons, where TB preventive therapy (TPT) implementation has been limited. Prisons generally, and especially in Malaysia, are overcrowded, minimally resourced, and have high prevalence of latent…
M.F. Martins, Juan M Teran Plasencia, Pranay Sinha, Carlos Acuña-Villaorduña
…ed similar rates of discontinuation over time between the 2 regimens (Figure 1). After adjusting for key confounders using multivariable logistic regression model, the sole variable significantly associated with LTBI treatment completion was the use of 4R with an odds ratio of 2.…
Anu K. Murthy, Richard A. Goodman, Miranda A. Moore
…dies. Strengthening education, follow-up, access to shorter regimens, and documentation may improve completion rates and support TB elimination goals.
Asare-Baah M, Salmon-Trejo LAT, Venkatappa T, Garfein RS, Aiona K, et al.
…%). Time at risk of TPT discontinuation was compared across regimens. Risk factors were assessed using mixed-effects Cox models. Results Short-course TPT discontinuation was higher with 4R (31% vs 14%; P Conclusions TPT discontinuation differed by regimen, with distinct risk fact…
Plans-Rubió P, Godoy S, Toledo D, Domínguez A, Caylà J, et al.
…th latent TB infection by recommending short-term treatment regimens and by developing health education activities, with a greater focus on contacts with factors associated with treatment non-adherence.
Krishnan S, Chaisson RE
…ulations is critical for global control. Shorter-course TPT regimens are highly effective and improve completion rates. Despite incorporation of 1 month of rifapentine and isoniazid into global guidelines, current US TPT guidelines do not include this as a recommended regimen, bu…
Farooqi S, Horvath L, Miljkovic E, Mohamed A, Williams SP
Background Treatment of latent tuberculosis infection (LTBI) is essential for refugee patients who have been relocated to the United States to prevent progression to active infection. Objective This study aimed to determine the effectiveness of a multidisciplinary team approach, …
Tomislava Skuhala, Anja Dragobratović, Luka Marinković, Kristina Ramljak, Marin Rimac, et al.
…isticated diagnostics. Promising advancements include safer regimens like the 3-month once-weekly isoniazid-rifapentine (3HP) for latent TB, which significantly reduces hepatotoxicity. The development of shorter active TB regimens and novel anti-TB drugs with improved safety prof…
Pennington KM, Kennedy CC, Chandra S, Lauzardo M, Brito MO, et al.
…vored bronchoscopic testing (69.2%). Preferred TB treatment regimens in SOT recipients were similar to regimens recommended for immunocompetent patients. Conclusions : Most TB and transplant experts recommend evaluation and treatment for LTBI in SOT candidates. Liver transplant c…
Stockbridge EL, Miller TL, Carlson EK, Ho C
…, and (2) estimate treatment completion rates for isoniazid regimens from commercial insurance claims. Methods Medical and pharmacy claims data representing insurance-paid services rendered and prescriptions filled between January 2011 and March 2015 were analyzed. Participants F…
Vonnahme LA, Raykin J, Jones M, Oakley J, Puro J, et al.
Introduction Prevention of tuberculosis disease through diagnosis and treatment of latent tuberculosis infection is critical for achieving tuberculosis elimination in the U.S. Diagnosis and treatment of latent tuberculosis infection in safety-net primary care settings that serve …
Malhotra S, Dasgupta-Tsinikas S, Yumul J, Kaneta K, Lenz A, et al.
Objectives To evaluate implementation of rifamycin-based regimens (RBR) for pediatric tuberculosis infection (TBI) treatment among 3 provider settings in a high-incidence county. Study design A multicenter, retrospective observational study was performed across 3 sites in Los Ang…
Park SY, Lee E, Lee EJ, Kim TH, Kim YK
… carefully monitored in those receiving rifampin-containing regimens.
Yuen CM, Majidulla A, Jaswal M, Safdar N, Malik AA, et al.
… for tuberculosis elimination. Shorter preventive treatment regimens currently have higher medication costs, but patients spend less time in care and are more likely to complete treatment. It is unknown how economic costs of successful delivery differ between longer and shorter r…
Sang-Heon Kim, MD, PhD.
The investigators aim to study the prevalence of adverse reactions of anti-tuberculosis (TB) drugs in latent tuberculosis infection (LTBI), and determine the risk factors of anti-TB drug-related toxicity in LTBI in Korean health care workers(HCWs). Further study details as provi…
It is recommended that infertile women undergoing assisted reproduction should undergo LTBI testing. For those with latent genital TB, TPT is recommended using regimen for active TB treatment. For those with LTBI and reproductive system samples that are negative for TB nucleic ac…
Elisa H Ignatious, Susan Swindells
…ease has been onerous for patients; however, shorter-course regimens are increasingly available across the spectrum of TB, including for drug-resistant TB. Simultaneous treatment of HIV and TB is complicated by drug-drug interactions, although trials are ongoing to better underst…
Kadota JL, Musinguzi A, Nabunje J, Welishe F, Ssemata JL, et al.
…le living with HIV (PLHIV) on common antiretroviral therapy regimens. The best approach to delivering 3HP to PLHIV remains uncertain. Methods We developed a three-armed randomized trial assessing optimized strategies for delivering 3HP to PLHIV. The trial will be conducted at the…
Zhang X, Zhao R, Qi Y, Yan X, Qi G, et al.
Tuberculosis (TB) has been troubling humans for hundreds of years, is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, Mtb can infect almost all organs of the body and is one of the deadly infectious diseases in the world. At present, the first-li…