Showing 176–200 of 200 documents
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Vasilevska L, Auzenbaha M, Grinfelde I, Skangale A
Mucopolysaccharidosis type I S (MPS IS) is a rare autosomal recessive lysosomal storage disorder caused by mutations in the IDUA gene, leading to a deficiency of the enzyme alpha-L-iduronidase. Enzyme replacement therapy (ERT) reduces lysosomal storage in the liver and improves c…
Roohallah Yousefi
Tuberculosis (TB) is a significant disease that causes numerous illnesses and deaths worldwide. TB remains one of the top ten causes of infectious disease deaths globally. The risk of TB increases with age, inadequate treatment, and drug resistance. Multi-drug-resistant TB (MDR-T…
Carolina Longo, Karina Felippe Monezi Pontes, Marina Matos de Moura Faíco, Mayra Martins Melo, Gustavo Yano Callado, et al.
Tuberculosis remains one of the leading infectious causes of morbidity and mortality worldwide, disproportionately affecting women of reproductive age, particularly in low- and middle-income countries. Tuberculosis during pregnancy represents a major clinical challenge, as physio…
Acquah R, Mohr-Holland E, Daniels J, Furin J, Loveday M, et al.
This brief report presents a series of 5 pregnant women treated for rifampicin-resistant tuberculosis with the novel drugs bedaquiline, delamanid, and linezolid as part of an optimized backbone regimen and reviews the outcomes of the children born to them. Although the case serie…
Lhadon T, Jullien S
Multidrug-resistant tuberculosis (MDR-TB) is a well-identified raising public health concern worldwide. However, the data available on MDR-TB in children and particularly in the neonate age group are limited. Congenital tuberculosis (TB) is rare, and its diagnosis is challenging …
Janssen Research & Development, LLC Clinical Trial
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (explores what the body does to the drug), and anti-mycobacterial activity of bedaquiline (TMC207) in children and adolescents (0 months to less than \[\<\] 18 years of age) diagnosed with confirm…
Zahedan University of Medical Sciences
This study aims to investigate the relationship between HIV infection and multi-drug resistant tuberculosis (MDR-TB) among affected individuals in Zahedan, Iran. It will involve a detailed analysis of patient demographics, clinical characteristics, and treatment outcomes to enhan…
Huguet A, Ader F, Ohlmann C, Collardeau-Frachon S, Gillet Y
We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced f…
Nataprawira HM, Gafar F, Sari CA, Alffenaar JC, Marais BJ, et al.
Background Data on childhood and adolescent multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in Indonesia are lacking. We aimed to assess clinical features, adverse events (AEs) and treatment outcomes of childhood and adolescent MDR/RR-TB. Methods A retrospective cohort st…
Abebaw Y, Abebe M, Tola HH, Mehammed Z, Getahun M, et al.
Introduction Data on the burden of bacteriologically confirmed childhood Tuberculosis (PTB) and drug-resistant TB in Ethiopia is limited due to difficulties related to its diagnosis in this population. Therefore, this study aimed to assess bacteriologically confirmed childhood PT…
Rao GG, Konicki R, Cattaneo D, Alffenaar JW, Marriott DJE, et al.
Linezolid is an antibiotic used to treat infections caused by drug-resistant gram-positive organisms, including vancomycin-resistant Enterococcus faecium, multi-drug resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus. The adverse effects of linezo…
Reena Ughreja, Vaibhav Bhatt, Sunny Shah, Devang Boxa
Background: Mycobacterium tuberculosis causes tuberculosis (TB), the most lethal infectious disease in the world that affects people of all ages. The aim of our study was to estimate the prevalence of TB in the Gujarat state (India). \nMaterial and methods: This was a retrosp…
Vikas Marwah, Gaurav Bhati, Robin Chaudhary, Anmol Sharma
Background: Pulmonary tuberculosis (PTB) is an established cause of arterial and venous thrombosis. With the rising incidence of multidrug-resistant tuberculosis (MDR TB), which has a prolonged treatment course, pulmonary thromboembolism in such cases further complicates the trea…
Mirza Mahendra Putra, Ni Made Mertaniasih, Ariani Permatasari, Arief Bakhtiar
Tuberculosis or TB is a global problem because of it high number globally. The 2021 WHO report shows that in 2020 there were around 9.9 million TB cases of which 1.2 million died. Of the total cases, 465,000 were MDR/RR-TB case. In Indonesia, TB RO is estimated to reach 2.4% of t…
Rajabali Sharifov, Dilyara Nabirova, Zulfiya Haybullo Tilloeva, Sanam Zikriyarova, Salomudin Yusufi, et al.
Abstract Background Delays in TB treatment prolong the period of infectivity and are associated with drug resistance. Tajikistan has a high and increasing burden of multidrug-resistant tuberculosis (incidence of 28/100,000 in 2021). Many new cases present with severe disease, ind…
Wai Lai Chang
Tuberculosis (TB) remains the world’s second leading cause of death from a single infectious agent in 2022 after COVID-19[1]. The global number of people newly diagnosed with TB was over 10 million in 2022 [1]. There were an estimated 450 000 incident cases of MDR/RR-TB in 2021, …
Joyce Felicia Vaghela
Background: Adverse drug reactions are common in MDR-TB patients on treatment. An adverse drug reaction (ADR) is defined as an appreciably harmful or unpleasant reaction resulting from an intervention related to the use of a medicinal product. Revised National Tuberculosis Contro…
Е. И. Никишова, T. I. Guryeva, Natalia Vlasova, A.A. Markova, Z.E. Jafarova, et al.
An observation of the management of active and latent tuberculosis with multidrug resistance of the causative agent of the disease in children from the same family has been presented. The efficacy and safety of a short, fully oral chemotherapy regimen with the use of new and repu…
Nijman RG, Bressan S, Brandenberger J, Kaur D, Keitel K, et al.
This joint statement by the European Society for Emergency Paediatrics and European Academy of Paediatrics aims to highlight recommendations for dealing with refugee children and young people fleeing the Ukrainian war when presenting to emergency departments (EDs) across Europe. …
Singh UB, Verma Y, Jain R, Mukherjee A, Gautam H, et al.
Diagnosis of intra-thoracic tuberculosis (ITTB) in children is difficult due to the paucibacillary nature of the disease, the challenge in collecting appropriate specimens, and the low sensitivity of smear microscopy and culture. Culture and Xpert MTB/RIF provide higher diagnosti…
Garcia-Prats AJ, Starke JR, Waning B, Kaiser B, Seddon JA
After almost 30 years of relative stagnation, research over the past decade has led to remarkable advances in the treatment of both drug-susceptible (DS) and drug-resistant (DR) tuberculosis (TB) disease in children and adolescents. Compared with the previous standard therapy of …
Schaaf HS, Hughes J
Optimal diagnosis and management of children aged <15 y with rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB) relies on identification of adults with the disease and pro-active screening of their close contacts. Children may be diagnosed with RR/MDR-TB based on microbi…
Mst. Taslima Khatun, Mst. Ronju Ara Khatun, Renu Ara Begum, Most. China khatun, SSN, Upazila Health Complex, Laksam, Cumilla, Bangladesh.
Tuberculosis (TB) remains a significant global public health concern, with Pulmonary Tuberculosis (PTB) constituting a substantial burden. This study aimed to assess the socio-demographic profile of PTB patients, with a focus on Multi-Drug Resistant Tuberculosis (MDR-TB) cases, a…
A.V. Zakharov, S.G. Bazazhi, O.V. Demikhova, V.V. Romanov, Atadzhan Ergeshov
According to the data of a retrospective assessment of the medical histories of 238 patients, the features of the clinical course of pulmonary tuberculosis in patients with late-stage HIV infection and mental pathology in various morbid variants are considered in a comparative as…
Diya Surie, M.K. Sathyanarayanan, J. Lavanya, Jonathan P. Smith, Surendran K. Shanmugam, et al.
India has the largest number of multidrug-resistant TB (MDR-TB) cases, defined as Mycobacterium tuberculosis resistant to at least isoniazid (INH) and rifampicin (RIF).1 However, less than half of all persons with MDR-TB in India successfully complete treatment.1 Although initial…