Showing 151–175 of 200 documents
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Binayak Rimal, Ruth A. Howe, Chandra M. Panthi, Gyanu Lamichhane
…uppression. Current treatments involve prolonged multi-drug regimens with poor outcomes and significant side effects, highlighting the urgent need for improved therapies. Using a BALB/c mouse model of chronic M. avium pulmonary disease, we evaluated the efficacy of individual ant…
Soham Samajpaty
Mumbai Protocol is a shot in darkness in the field of tuberculosis research. At a time when clinicians around the world are obsessed with rifampicin to an extent of believing that no regimen against tuberculosis can work without it, the Mumbai protocol has opened a new avenue in …
Sun Y, Cao B, Rao W, Li X, Yu B, et al.
…is study was to evaluate the efficacy and safety of two FDC regimens in two provinces with a high tuberculosis burden. A total of 2,353 newly diagnosed active pulmonary TB patients were recruited from Shandong Province (n=1,223) and Jilin Province (n=1,130). Participants received…
Mohr-Holland E, Reuter A, Furin J, Garcia-Prats A, De Azevedo V, et al.
…treatment of adolescents (10-19 years) with injectable-free regimens containing these drugs in Khayelitsha, South Africa. Methods This retrospective study included adolescents initiating injectable-free RR-TB treatment regimens containing bedaquiline and/or delamanid from Februar…
Dongshuo Li, Liang Li, Ye Zhang, Kai Cheng, Wenwen Liang, et al.
…nd survival. Our research delved into the efficacy of novel regimens targeting the OxPhos pathway in murine models. The combination of bedaquiline, clofazimine, pyrazinamide, alongside telacebec, and SQ109 was investigated against both wild-typeH37Rv and anmutant with cross-resis…
Kusmiati T, Made Mertaniasih N, Nugroho Eko Putranto J, Suprapti B, Luthfah N, et al.
…cin and QTc interval in RR-TB patients who received shorter regimens is needed. Methods This was an observational study in 2 groups of RR-TB patients on shorter treatment regimens (intensive phase and continuation phase), contain moxifloxacin with body weight-adjusted dose. Blood…
Nana Kiria, Zaza Avaliani, N Bolokadze, Nino Kiria, Lali Mikiashvili
…ated by hepatotoxicity. <b>Aim:</b> To assess the effect of regimens containing bedaquiline (Bdq) and delamanid (Dlm) on liver function in a high-risk group of pts. <b>Methods:</b> An observational cohort study was conducted in Georgia among DR-TB pts co-infected with HIV and vir…
Christian T Michael, Maral Budak, Pauline Maiello, Kara Kracinovsky, Mark Rodgers, et al.
…e quarantined, complicating and prolonging multi-antibiotic regimens. Determining which antibiotic regimens are optimal for reducing treatment time and toxicity is a goal of recent TB eradication campaigns. Clinical trials are expensive and challenging, making it difficult to unt…
Souleymane MB, Kadri S, Piubello A, Tsoumanis A, Soumana A, et al.
Objectives High-dose rifampicin (R) and isoniazid (H) are known to be safe but were not yet combined in a single regimen. The primary objective of the TRIple-DOse RE-treatment (TRIDORE) study is to determine whether a 6-month firstline regimen with triple dose of both R and H (in…
Almaghrabi RS, Nizami I, Alameer R, Alshehri N, Almohaizeie A, et al.
…ulosis in lung transplant recipients with rifamycin-sparing regimens are so far limited. Therefore, we evaluated the incidence, clinical features, treatment, and outcomes of active tuberculosis in lung transplant patients from a single center in Riyadh, Saudi Arabia. Materials an…
… optimize the in vivo doses of each drug in the most potent regimens. Thus, regimens are identified that are dramatically more effective than the Standard Regimen in treating TB in a mouse model—a model broadly predictive of drug efficacy in humans. The most effective regimens re…
Schwœbel V, Trébucq A, Kashongwe Z, Bakayoko AS, Kuaban C, et al.
Background Treatment outcomes of the shorter regimen for rifampicin-resistant tuberculosis are not completely established. We report on these outcomes two years after treatment completion among patients enrolled in an observational cohort study in nine African countries. Methods …
Joseph G. Kariuki, Symon M. Kariuki, Phuti Angel
…d neurotoxicity are well-known adverse effects of treatment regimens that cause significant morbidity. Pyridoxine is often added to treatment regimens for the prevention and/or treatment of these side effects. The basis and effectiveness of this practice are unclear. We conducted…
Anurag Agarwal, Shivanand Hosatti, Deepak Kumar, Ashwani Khanna, Vishal Khanna, et al.
…rences in treatment failure or recurrence rates between the regimens, however, patients who received three times weekly dosing throughout the therapy exhibited higher rates of acquired drug resistance.This study was undertaken due to the significant lack of available data in the …
Jinhong He, Xiangxi He, Xiaoxin Xie, Yanhua Fu, Xingxing Luo, et al.
…009;+ 3TC when combined with rifabutin-based anti-TB regimens in patients with TB and HIV.
Drusano GL, Kim S, Almoslem M, Schmidt S, D'Argenio DZ, et al.
…eutic ends, it is requisite to identify optimal combination regimens. These regimens go through a lengthy and expensive evaluative process. If we have a modest group of 6 to 8 new or repurposed agents, this translates into 15 to 28 possible 2-drug combinations. There is neither t…
Catherine Berry, Ilaria Motta, Emil Kazounis, Katherine Fielding, Matthew Dodd, et al.
…led, multi-country, non-inferiority trial comparing 24-week regimens to the locally approved standard of care (control). We report TB-PRACTECAL stage 1 and 2 outcomes as well as additional analyses from dropped arms. METHODS Participants 15 years and above with pulmonary RR-TB fr…
Vincent Okech Moro, John Mbaziira Ssenkusu, Flavia Matovu Kiweewa
…iversal transition to the much effective Dolutegravir-based regimens. Therefore this study was aimed at determining the prevalence of virological non-suppression and its associated correlates among children and adolescents aged 5-19 years on Dolutegravir-based regimens. **METHOD…
Devika Mukherjee, Peter Wang, Lissa Hooi, Vedant Sandhu, Kui You, et al.
Background: Current standard of care (SOC) regimens against nontuberculous mycobacteria (NTM) usually result in unsatisfactory therapeutic responses, primarily due to multi-drug resistance and antibiotic susceptibility-guided therapies. In the midst of rising incidences in NTM in…
J A Koroma, B D Fofanah, D Nair, E M Kamau, I F Kamara, et al.
…cin) and the standardised short and the individualised long regimens among DR-TB patients and identify predictors of unsuccessful outcomes. **DESIGN:** Retrospective cohort study utilising routinely collected national DR-TB data from January 2022 to December 2024. **RESULTS:** …
Drusano GL, Neely MN, Kim S, Yamada WM, Schmidt S, et al.
…ously identified a mathematical approach to identify 2-drug regimens with a synergistic or additive interaction using a full factorial study design. Our objective here was to generate a method to identify an optimal 3-drug therapy. We studied M. tuberculosis isolate H37Rv in log-…
Christiaan Mulder, Alanna Bergman, Fiseha Mulatu, Richard E. Chaisson, Gavin Churchyard, et al.
…ell understood. We explored perceptions of two short-course regimens - 3HP (weekly dosing) and 3RH (daily dosing) - among interest-holders in Ethiopia. METHODS: Forty-seven in-depth interviews were conducted with caregivers of TB-exposed children, community health workers, health…
Arriaga MB, Torres NMC, Araujo NCN, Caldas SCC, Andrade BB, et al.
Background The Ministry of Health in Brazil included ethambutol in the intensive phase of sensible tuberculosis (TB) treatment in March 2010, due to the increasing drug resistance, and implemented the fixed dose combination in the TB treatment guidelines. Methods A retrospective …
Lodiong LJD, Izudi J, Amos T, Twinomugisha B, Kulaba N, et al.
…ug-resistant tuberculosis (DR-TB) on bedaquiline-containing regimens are at risk for a prolonged corrected QT (QTc) interval but this problem is understudied in low-resource countries. We determined the magnitude and risk factors for QTc interval prolongation among people with DR…
Luo PP, Wu L, Liu F, Tian YH, Chen LY, et al.
Objective To evaluate the clinical efficacy of a chemotherapy regimen combined with levofloxacin in patients with pulmonary tuberculosis complicated with Type-2 diabetes. Methods Total 80 patients with pulmonary tuberculosis complicated with Type-2 diabetes admitted to Baoding Pe…