Showing 126–150 of 200 documents
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Ashura Mayanda, Robert Kaaya, B. Sylvester, Reginald A. Kavishe
…1) and Theta 1 (GSTT1) have been reported to associate with drug resistance in cancer patients and also reported to influence the severity of malaria. This work aims to assess the effect of sex and human glutathione transferase null genotypes on TB drug resistance. The objectives…
Schwab TC, Perrig L, Göller PC, Guebely De la Hoz FF, Lahousse AP, et al.
…rapidly and simultaneously detect mutations associated with resistance to tuberculosis drugs across multiple gene targets. The use of targeted NGS to diagnose drug-resistant tuberculosis, as described in publicly available data, has not been comprehensively reviewed. We aimed to …
Amirkan A Azembayev, Cond.Phar.Sc.
Drug-resistant tuberculosis is becoming a major problem for the whole humanity, and development of new Anti-TB drugs is of great importance. Since Kazakhstan is a country with the high burden of tuberculosis, the Government of the Republic of Kazakhstan has founded initiative on …
Wang R, Jin L, Cui H, Zhang J, Zhang X, et al.
…uberculosis (TB) remains a significant global health issue. Drug-resistant TB and comorbidities exacerbate its burden, influencing treatment outcomes and healthcare utilization. Despite the growing prevalence of TB comorbidities, research often focuses on single comorbidities rat…
Maria Rafique, Muhammad Ibrahim, Sumaira Kanwal, Habib Bokhari, Farrukh Jamil, et al.
Development of multidrug-resistant tuberculosis is the after effect of various mutational occasions, which leads to the development of protection from hostile to multiple tuberculosis drugs. In this study, we identified drug resistance genes, their evolutionary analysis, mutation…
Mahmut Ulger, Nurcihan Biltekin, Seda Tezcan Ulger, Gonul Aslan
Early and rapid diagnosis of drug resistance in tuberculosis (TB) plays a key role in reducing the spread of resistance and enabling effective treatment. The aim of this study was to investigate mutations in drug resistance-associated gene regions ofcomplex (MTBC) isolates resist…
Masood R, Muhammad IN, Siddiqui T, Mushtaque M, Irshad A
…ort 2018, Pakistan is amongst the 30 countries high TB with drug-resistant Mycobacterium tuberculosis particularly MDR (multi-drug resistant strains). A retrospective study had been designed using DR-TB patients' records from January 2013 to the December 2017 year from a public s…
Saira Salim, Syed Asim Ali Shah, Fareena Asim, Saba Anwar, Aniqa Shoukat, et al.
…e between genotypic and phenotypic methods for detection of drug resistant Mycobacterium tuberculosis. Material and Methods: This cross-sectional validation study was conducted from January to September 2024 in BSL-3 laboratories of Islamabad Diagnostic Center, Izzat Ali Shah Hos…
Song WM, Guo J, Xu TT, Li SJ, Liu JY, et al.
Background Drug-resistant tuberculosis (DR-TB), obesity, and malnutrition are growing public health problems in the world. However, little has discussed the impact of different BMI status on the emergence of TB drug resistance. We aimed to explore the drug-resistant profiles of D…
Datta D, Jamwal S, Jyoti N, Patnaik S, Kumar D
The emergence of antimicrobial resistance (AMR) across bacterial pathogens presents a serious threat to global health. This threat is further exacerbated in tuberculosis (TB), mainly due to a protracted treatment regimen involving a combination of drugs. A diversity of factors co…
Gliddon HD, Frampton D, Munsamy V, Heaney J, Pataillot-Meakin T, et al.
Phenotypic drug susceptibility testing (DST) for tuberculosis (TB) requires weeks to yield results. Although molecular tests rapidly detect drug resistance-associated mutations (DRMs), they are not scalable to cover the full genome and the many DRMs that can predict resistance. W…
Paolo Miotto, Rebecca E Colman, Andrea M Cabibbe, Paola M V Rancoita, Federico Di Marco, et al.
…ics have significantly improved access to tuberculosis (TB) drug resistance detection and reduced turnaround times. However, these tools remain limited in their capacity to generate comprehensive resistance profiles, particularly for newer and repurposed anti-TB drugs. Targeted n…
Sümeyya Çapuk, Gülnur Tarhan, İsmail Ceyhan
Aim of the study: Multi-drug resistant tuberculosis (MDR-TB) is still an important public problem. Rapid diagnosis of the agent and determination of resistance status are critical in establishing the correct treatment protocol. This study was conducted with the aim of determining…
Mani Sharma, Sakshi Kansal
…are numerous factors responsible for the emergence of multi-drug resistance and extensively drug resistance cases of tuberculosis, which involves high pill burden, prolonged treatment, low compliance, and stiff administration schedules. Continuous efforts have been done to develo…
Muhammad Fachri, Mochammad Hatta, Fauziah Zafira, Risky Akaputra, Tri Ariguntar Wikanningtyas
…treat to understand the effects of TB and oral antidiabetic drugs. The purpose of this study was to compare the duration of treatment for drug-resistant pulmonary TB in the presence and absence of type 2 DM. Methods: This study used a cross-sectional design and single-population …
Mbelele PM, Utpatel C, Sauli E, Mpolya EA, Mutayoba BK, et al.
Background Rifampicin- or multidrug-resistant (RR/MDR) Mycobacterium tuberculosis complex (MTBC) strains account for considerable morbidity and mortality globally. WGS-based prediction of drug resistance may guide clinical decisions, especially for the design of RR/MDR-TB therapi…
Peng Y, Li C, Hui X, Huo X, Shumuyed NA, et al.
…te the geographic prevalence of tuberculosis and medication resistance, as this information is essential for informing strategies for its prevention and treatment. Drug resistance was identified using a proportion method. Drug-resistant genes and pathways were predicted using who…
Claudio Damião Rosa, Lucilaine Ferrazoli, Debora Pereira Dos Santos, Carolina Pedace, Naila Cristina Soler-Camargo, et al.
… whole-genome sequencing (WGS) ofcomplex isolates to detect drug-resistant tuberculosis (DR-TB). This endorsement was based on the assumption that a faster and more detailed description of the resistance profile would improve treatment prescription for DR-TB by healthcare provide…
Nitin Mohan, Indugula Jyothi Padmaja, Ratna Harika Dusi, K P Suresh
…ture Mycobacterium tuberculosis from sputum samples of multidrug resistance (MDR) suspects on Lowenstein-Jensen (LJ) media, to test for susceptibility and resistance to first-line antitubercular drugs rifampicin (RMP), isoniazid (INH), streptomycin (SM), and ethambutol (EMB) by c…
Singh R, Dwivedi SP, Gaharwar US, Meena R, Rajamani P, et al.
…d with TB leading to nearly 1·6 million deaths annually. TB drugs are administered in different combinations of four first-line drugs (rifampicin, isoniazid, pyrazinamide and ethambutol) which form the core of treatment regimens in the initial treatment phase of 6-9 months. Sever…
Derendinger B, Dippenaar A, de Vos M, Huo S, Alberts R, et al.
Background Bedaquiline is a life-saving tuberculosis drug undergoing global scale-up. People at risk of weak tuberculosis drug regimens are a priority for novel drug access despite the potential source of Mycobacterium tuberculosis-resistant strains. We aimed to characterise beda…
Schwab TC, Joseph L, Moono A, Göller PC, Motsei M, et al.
Rapid and comprehensive drug susceptibility testing (DST) is essential for diagnosing and treating drug-resistant tuberculosis effectively, and next-generation sequencing can be an effective genotypic DST method. We implemented and evaluated the performance of a nanopore targeted…
Manita Yimcharoen, Sukanya Saikaew, Usanee Anukool, Ponrut Phunpae, Sorasak Intorasoot, et al.
…ction. The main problem of TB treatment is the emergence of drug resistance, which can occur by inappropriate of antibiotic used. Isoniazid (INH) is the first-line anti-TB drug that inhibits mycolic acid synthesis, an important part of the mycobacterial cell wall. Mannose-capped …
Song WM, Li SJ, Liu JY, Fu Q, Xu TT, et al.
…ctive impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis (TB). Design This was a retrospective cohort study. Setting Shandong, China. Participants Patients with newly diagnosed TB from 1 January 2004 to 31 December 2020 were coll…
Vyawahare C, Mukhida S, Khan S, Gandham NR, Kannuri S, et al.
…oblem worldwide and the risk progression of Tuberculosis to Drug Resistant Tuberculosis is influenced by various factors. These include immunocompromised status, past history of tuberculosis, life style and nutritional level. Hence, identifying the population at risk of multidrug…