Showing 101–125 of 180 documents
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Serena Koenig, MD, MPH, Sean Wasserman, MBChB, PhD
…ation will be stratified by presence of lung cavitation and HIV status. Participants will be randomized to one of two arms: Arm 1 (Experimental): BDQ 200 mg for 12 weeks + PZA 1000 - 2000 mg (according to weight) for 12 weeks + CFZ 300 mg for 2 weeks, followed by 100 mg for 10 …
M.G. Mustapha, Garba Mohammed Ashir, AI Rabasa, Asmaa Farouk, Hassan Abdullahi Elechi, et al.
…hose with latent infection, contacts and people living with HIV and AIDS (PLWHA) in most developing countries.While significant similarities exist between spectrum of TB occurring in adults and children, the characteristics and peculiarities of childhood TB may be unknown to poli…
Toua W, Lape V, Bolnga JW, Daimen M, Kelebi T, et al.
…rable treatment outcomes were significantly associated with HIV-untested (aOR 2.82 compared to HIV-negative; 95% CI 2.39-3.33), having drug-resistant TB (aOR 3.26 compared to drug-susceptible TB, 95% CI 1.18-9.00), and travel time to the health facility 1- Conclusion High LTFU fr…
M R Marll, M Magee, N Glover, T Ngwanto, N Mofokeng, et al.
…tudy in Johannesburg, South Africa, adults with and without HIV were enrolled at the time of drug-susceptible pulmonary TB diagnosis. At TB treatment completion, participants underwent comprehensive PFTs (spirometry, lung volumes by multiple breath washout, diffusion capacity) wi…
Ramnath Subbaraman, Beena Thomas, J Vignesh Kumar, Kannan Thiruvengadam, Amit Khandewale, et al.
…ble TB patients, about half of whom were people living with HIV (PLHIV), in Chennai, Vellore, and Mumbai. We conducted a single unannounced home visit to administer a survey assessing reasons for non-adherence and collect a urine sample that was tested for isoniazid content. We d…
Katarina Niward, MD, PhD
Tuberculosis (TB) treatment is long and complex with the risk of poor treatment adherence and treatment failure. Several attempts to shorten treatment of drug-susceptible TB have been unsuccessful. However, recent data support a shortened regimen for mild and moderate pulmonary T…
Digby F. Warner, Robin Wood
…societal instability and, since the late 20th century, high HIV prevalence. An ancient disease which has plagued humanity for millennia, TB often defies definitive diagnosis, especially in those most at risk, such as children and people living with HIV, where presentation can be …
Heiman F Wertheim, PhD
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis. Diagnostic criteria are non-specific and culture confirmation is challenging, as sputum samples are not…
First Affiliated Hospital of Zhejiang University
This study is a clinical trial conducted to determine whether the sitafloxacin-containing three-month regimens are as effective as the standard six-month regimen and the four-month rifapentine and moxifloxacin regimen (substitution of rifapentine for rifampin and moxifloxacin for…
Tadesse AW, Cusinato M, Weldemichael GT, Abdurhman T, Assefa D, et al.
…, 0.96). In both evaluation periods (56-days and 168-days), HIV-positive status (RR a :1.29; 95%CI: 1.02, 1.63 and RR a :1.28; 95%CI: 1.07, 1.53), single/living independent (RR a :1.31; 95%CI: 1.03, 1.67 and RR a :1.38; 95%CI: 1.16, 1.64) and separated/widowed (RR a :1.40; 95%CI:…
Hassane-Harouna S, Gils T, Decroo T, Ortuño-Gutiérrez N, Delamou A, et al.
…led TB patients, 237 (66.0%) were male, and 37 (10.3%) were HIV-positive. Three hundred forty (94.7%) participants had treatment success, seven (1.9%) died, seven (1.9%) experienced treatment failure, and five (1.4%) were lost-to-follow-up. Among 1585 household contacts screened …
Proaño A, Bui DP, López JW, Vu NM, Bravard MA, et al.
…een studied. Methods We analyzed data in 41 adults who were HIV negative and had culture-confirmed, drug-susceptible pulmonary TB throughout treatment. Cough recordings were based on the Cayetano Cough Monitor, and sputum samples were evaluated using microscopic observation drug …
Olanisun P Adewole, MD, Bolanle A Omotoso, MD
…e regimen with minimal side effects including patients with HIV/TB co-infection, as statins can be co-administered safely with antiretroviral drugs. Additionally, the investigators anticipate a reduction in relapse rate, persistence and resistance to Mycobacterium tuberculosis. C…
Ryuk DK, Pelissari DM, Alves K, Oliveira PB, Castro MC, et al.
…(aOR 2.03 [1.91-2.17], vs. complete high school education), HIV infection (aOR 2.72 [2.63-2.81], vs. no HIV infection), illicit drug use (aOR 1.95 [1.88-2.01], vs. no illicit drug use), alcohol consumption (aOR 1.46 [1.41-1.50], vs. no alcohol consumption), smoking (aOR 1.20 [1.1…
Peetluk LS, Rebeiro PF, Ridolfi FM, Andrade BB, Cordeiro-Santos M, et al.
…ated the incremental value of human immunodeficiency virus (HIV)-related severity and isoniazid acetylator status. Methods Data originated from the Regional Prospective Observational Research for Tuberculosis Brazil cohort, which enrolled newly diagnosed TB patients in Brazil fro…
Sunday Olakunle Olarewaju, Sunday Charles Adeyemo, Ayomide Timilehin Kayode, Janet Oluwaseyi Ayinmodu, Olushina Ololade Oladeji, et al.
…red to Tertiary level of education. Respondents living with HIV were 35 times more likely to develop depression (AOR = 35.303, P = 0.017) compared to those who were HIV negative. CONCLUSION: This study found a high prevalence of depression among TB patients. Factors such as no fo…
Carole D Mitnick, Sc.D, Geraint Davies, B.M., Ph.D
… heterogeneity within strata (e.g., presence of cavitation, HIV serostatus), will be adjusted for in analyses. It is important to maintain the ability to measure the effect (if any) of these potential characteristics on treatment outcome. If we were to stratify on these character…
Christopher Cousins, MBChB PhD, Sean Wasserman, MBChB PhD, John Eikelboom, MBBS FRCPC
…gibility criteria allow for enrolment of people living with HIV, diabetes, other common comorbidities.
OBrien S, Griffin B, McLaughlin AM, Keane J
…al worsening of symptoms and radiological features. She was HIV negative. A severe acute kidney injury with features of glomerulonephritis was evident on admission. Perinuclear ANCA and antimyeloperoxidase antibodies were present in serum and renal biopsy was consistent with ANCA…
Malika Gabdullina, Saya Gazezova, Gulzhan Ayapova, Manar Smagul, Roberta Horth, et al.
… outcomes were: being male (aRR=1.4, 95%CI=1.1-1.8), having HIV (aRR=2.4, 95%CI=1.8-3.3), having drinking disorder (aRR=2.3, 95%CI=1.6-3.3) and experiencing homelessness (aRR=2.6, 95%CI=1.5-4.3) (Table 1). Protective factors for unfavorable TB treatment outcomes were: being 18-39…
Donekham Inthavong, Hend Elsayed, Phonesavanh Keonakhone, Vilath Seevisay, Somdeth Souksanh, et al.
…rs associated with treatment success included age under 45, HIV-negative status, a BMI of 18.5 kg/mor higher, and clinically diagnosed pulmonary TB. Further assessment is required for the operational feasibility to provide systematic nutritional assessment and counselling for peo…
Charles M, Richard M, Reichler MR, Koama JB, Morose W, et al.
Background On October 4, 2016, Hurricane Matthew struck southwest Haiti as a category 4 storm. The goal of this study was to evaluate the impact of the hurricane on tuberculosis (TB) services and patient outcomes in the three severely affected departments-Sud, Grand'Anse, and Nip…
Daniel W Fitzgerald, MD, Carl Nathan, MD, Jean William Pape, MD
This research is being done to determine if Nitazoxanide (NTZ) will cause a significant decrease in the number of M. tuberculosis bacteria in sputum after 14 days of treatment. The study is being conducted at the GHESKIO Centers in Port au Prince Haiti This is a prospective rand…
Stephanie Law, Annabel Baddeley, Anna Carlqvist, Farai Mavhunga, Kerri Viney, et al.
…d substance use disorders, diabetes, Hepatitis C, lupus and HIV); half of whom reported more than one comorbidity, and all faced socioeconomic hardships. TB diagnosis and treatment exacerbated participants' comorbidities and, in the absence of integrated support, precipitated men…
Lee GO, Comina G, Hernandez-Cordova G, Naik N, Gayoso O, et al.
…morbidity. Cough characteristics were similar regardless of HIV co-infection and for drug-susceptible versus drug-resistant tuberculosis. Tuberculosis treatment response may be meaningfully assessed by objectively monitoring the time spent coughing. This measure demonstrated that…