Showing 76–100 of 200 documents
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Sahoo SK, Ahmad MN, Kaul G, Nanduri S, Dasgupta A, et al.
… cytotoxicity (SI >80). Further studies on activity against drug resistant (DR) Mtb indicated these compounds to be equally potent (MIC 0.03-0.25 μg mL -1 ). The in silico covalent docking study suggested a similar polar interaction to that of PBTZ169 with an additional and contr…
Mbano IM, Mandizvo T, Rogich J, Kunota TTR, Mackenzie JS, et al.
…a well-documented lack of rapid, low-cost tuberculosis (TB) drug resistance diagnostics in low-income settings across the globe. It is these areas that are plagued with a disproportionately high disease burden and in greatest need of these diagnostics. Methods In this study, we c…
B. P. Pirmakhmadzoda, Z. Kh. Tilloeva, Kh. S. Sharifzoda, Olim Kabirov, K. A. Imomnazarova, et al.
…nt HIV infection in Dushanbe and the prevalence of multiple drug resistant tuberculosis, to assess the treatment efficacy of drug susceptible and drug resistant tuberculosis depending on the HIV status of patients. Subjects: A cohort retrospective study was carried out assessing …
Ekaterina M. Petrunina, Sergey Skornyakov
…cobacterium tuberculosis (MTB) strains resistant to anti-TB drugs (ATD) remains a major challenge for TB treatment. Surgically obtained lung material plays an important role in assessing both the pathogen’s drug resistance and the host immune response. The relationship between mo…
Fatima S, Bhaskar A, Dwivedi VP
…which eliminates the bacteria and prevents the emergence of drug-resistance in patients if followed as prescribed. However, due to various limitations viz., severe toxicity, low efficacy and long duration; patients struggle to comply with the prescribed therapy, which leads to th…
Somoskovi A, Salfinger M
…the patient specimen? and (2) If so, is the strain detected drug susceptible or does it show any form of drug resistance? In cases of drug resistance, health care providers need to have access to minimal inhibitory concentration results and to the type of mutation conferring drug…
Shenzhen Third People's Hospital
…n, ranking third globally for total TB cases and second for drug-resistant TB cases. PAN-TB is an innovative concept in TB treatment, aiming to develop a universal regimen effective for all forms of active TB, including both drug-susceptible and drug-resistant strains. The primar…
Fry S, Barnabas S, Cotton MF
…ntact management, case identification and treatment of both drug-susceptible and drug-resistant TB. This review highlights some recent advances. Recent findings The tuberculin skin test is the most widely used test to distinguish Mycobacterium tuberculosis (M. tuberculosis) infec…
Alina Malic, Adriana Niguleanu, Tatyana Osipov
…us therapeutic regimens with a combination of at least four drugs. Adherence to the treatment regimen is crucial for efficacy outcomes based on the achievement of appropriate drug levels. Drug-resistant () strains are mainly favored by inadequate TB management. Inappropriate trea…
Helena Rabie, Marieke M. van der Zalm
…tant step to diagnose tuberculosis and to identify possible drug resistance. These tests significantly increase the diagnostic yield when compared with sputum smear and culture and reduce the time to treatment for people with drug-susceptible or drug-resistant tuberculosis.1WHOMa…
Tafaj S, Mokrousov I, Borroni E, Trovato A, Kapisyzi P, et al.
…w incidence of tuberculosis (TB) and very low prevalence of drug resistant TB. Here, we analyzed a country-wide multi-year Mycobacterium tuberculosis collection in order to detect possible dynamic trends of TB in Albania, with a focus on drug resistance and endemic/epidemic clone…
Ting Liu, Lei Zhang, Jiao Liu, Yao Liu, Anying Xiong, et al.
… the age-stratified burden and the shifting distribution of drug-resistant tuberculosis remain poorly defined in global health agendas. This study aims to employ data from the 2021 Global Burden of Disease Study to systematically evaluate the global, regional, and age-specific bu…
C. O. Ajanaku, Ademosun Theresa Olabisi, Ajanaku Kolawole Oluseyi, Owolabi Ayotunde Olayinka, Akintokun Oyeronke Abosede
…oot parts to be partially sensitive to the various types of drug resistant species of Mycobacterium tuberculosis: drug susceptible and drug resistance varieties. The volatile constituents present in the methanolic extracts of the leaf, stem and root of CA was analyzed using GCMS.…
Sang Chul Lee, Jae Kwang Lee, Jung Mo Lee, Seon Cheol Park, Chang Hoon Han
…tients were included in the final study population for each drug-susceptible and drug-resistant pulmonary TB. After implementing the cost exemption policy, the long-term treatment discontinuation rates tended to decrease in the continuation phase in the drug-susceptible TB group …
Naidoo K, Dookie N, Naidoo K, Yende-Zuma N, Chimukangara B, et al.
…in mediating the development of recurrent TB and subsequent resistance to antiretroviral therapy and anti-TB drugs. Patients and methods We analyzed secondary demographic, clinical, and laboratory data from medical records of five HIV-infected TB patients enrolled between 2009 an…
Banurekha Velayutham, M S Jawahar, Chandrasekaran Padmapriyadarsini
…d the rationality of using moxifloxacin in the treatment of drug-susceptible tuberculosis (TB). With reference to the first issue, the 6-month intermittent regimen was the standard of care in the Revised National TB Control Programme (RNTCP) throughout the recruitment phase of ou…
Malaisamy Muniyandi, Karikalan Nagarajan
… 6-month antituberculosis therapy (ATT), 85% of people with drugsensitive tuberculosis could be cured.1 However, this regimen still requires four medications and a minimum of 6 months of therapy. Long duration of treatment and drug-related toxicity leads to drug fatigue and non-c…
Harsh Shah, Sandul Yasobant, Jay Patel, Priya Bhavsar, Deepak Saxena, et al.
…he study targeted a diverse profile of TB patients, such as drug-sensitive TB (DSTB), drug resistance TB (DRTB), pediatric TB, and extra-pulmonary TB. It included both public and private sector patients. The study's findings suggested that 172 (29%) patients experienced ADRs with…
Bhaskar A, Kumari A, Singh M, Kumar S, Kumar S, et al.
…sis treatment (ATT) comprises exclusively of anti-bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the generation of drug-resistant variants. Therefore, a combination therapy directed against the pathogen and the host is required to counter tube…
O.M. Shvets, О.С. Шевченко
…rculosisMaterials and methods. We examined 76 patients with drug-susceptible pulmonary tuberculosis and 64 patients with drug-resistant pulmonary tuberculosis. The treatment was carried out according to the current order of the Ministry of Health of Ukraine. Material for the stud…
Nie L, Tong J, Wu G, Du J, Shang Y, et al.
…lling effect against Mycobacterium tuberculosis , including drug-resistant strains, which is superior to that of other available quinolones. However, its efficacy in patients with primary-sensitive tuberculosis is unclear. This study aims to evaluate the early bactericidal activi…
Amira Mahmood, Mohammad Bilal Ashfaq, Catherine Drain, Eoin Melby, Michael Hunter, et al.
…th an estimated 1.25 million deaths per year. The quadruple drug regimen of rifampicin, isoniazid, pyrazinamide, and ethambutol has been standard therapy for 40 years, with good outcomes in patients with drug susceptible tuberculosis who are able to tolerate the drug regimen. How…
Digby F. Warner, Robin Wood
…treatment of active disease, with the standard 6-month multidrug combination therapy posing a host of challenges for health systems, in conjunction with poor patient adherence. Key recent developments include innovations in composition and duration of combination therapies for bo…
Alipanah N, Jarlsberg L, Miller C, Linh NN, Falzon D, et al.
…tment failure, relapse, and development or amplification of drug resistance. We conducted a systematic review and meta-analysis of adherence interventions, including directly observed therapy (DOT), to determine which approaches lead to improved TB treatment outcomes. Methods and…
Heiman F Wertheim, PhD
…oportion of these non-sputum bodily fluids will detect both drug-susceptible and drug-resistant tuberculosis when sputum or gastric culture does not. Tuberculosis (TB) is a major cause of morbidity and mortality among children in developing nations. Symptom-based diagnostic crit…