Phytochemical, antimicrobial, antioxidant, antimycobacterial and gc-ms analysis of the plant Crateva adansonii

Crateva adansonii (CA), is a known therapeutic plant in several regions of Africa. This research study was considered to estimate the bioactivity of CA plant. Dried parts of CA plant were macerated in methanol solvent for seven days. The filtrate was concentrated to obtain the methanolic extracts of the root, stem and leaf of CA. The secondary metabolites identified the presence of saponins, terpenoids, alkaloids, and flavonoids in the arial, stem and root parts of Crateva adansonii. The total flavonoid and total phenolic content of the leaf, stem and root of CA were determined using two different solvents: hexane and methanol. The leaf contained more flavonoids and phenols from the hexane solvent; while the stem contained more of flavonoids and phenol from the methanol solvent Antimicrobial analysis of CA showed activity against P. aeuroginosa, S. aureus, and E. coli, by aqueous, chloroform and methanol fractions in the leaf, stem and root parts of the plant. The DDPH antioxidant assay revealed the free radical scavenging potential of CA. The antimycobacterial assay of different fractions of the CA plant indicated the hexane fraction of the leaf and root parts to be partially sensitive to the various types of drug resistant species of Mycobacterium tuberculosis: drug susceptible and drug resistance varieties. The volatile constituents present in the methanolic extracts of the leaf, stem and root of CA was analyzed using GCMS. These compounds have established biological relevance in CA, which affirms the plant’s wide ethno-botanical application.