Showing 76–100 of 200 documents
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A. V. Abramchenko, Anastasia Gaida, M. I. Romanova, Г. Н. Можокина, Irina A. Burmistrova, et al.
Abstract Background Short-term regimens with linezolid are an effective treatment for patients with MDR and pre-XDR TB (MDR/pre-XDR TB). However, their use is limited by the risk of adverse drug reactions (ADRs) associated with this drug. Objective To analyse the efficacy and ris…
Kempker R, Mikiashvili L, Zhao Y, Benkeser D, Barbakadze K, et al.
…tients receiving bedaquiline- and delamanid-based treatment regimens for drug-resistant TB had similar characteristics and those receiving bedaquiline had better clinical outcomes. Our results provide an important first comparison of bedaquiline vs. delamanid containing regimens.…
E.A. Krushinskaya
…ears in order to improve TB chemotherapy based on shortened regimens. The patients were hospitalized to the Central TB Research Institute in 2017–2021. The indications for shortened chemotherapy regimens were determined based on dynamic observation of TB course (clinical dynamics…
Putra ON, Yulistiani Y, Soedarsono S, Subay S
…vely searched and evaluated the effectiveness of individual regimens containing bedaquiline and delamanid on culture conversion and treatment success. We assessed for quality either observational or experimental studies. Results We identified 14 studies that met the inclusion cri…
Gupta A, Chopra V
…d to shorter courses of therapy as compared to the previous regimens which also consisted of injectables. Although, treatment for TB is evolving expeditiously today but a lot needs to be done as far as drug resistant TB (DRTB) is concerned. Non-standard regimens in private sector…
Michael Hoelscher- von Lovenberg, David Barros-Aguirre, Masoud Dara, Heinrich, Norbert, Eugene Sun, et al.
…of shorter duration, novel anti-TB medicines, and treatment regimens are needed. Through a joint global effort, more candidate medicines are in the clinical phases of drug development than ever before. Objectives: To review anti-TB medicines and treatment regimens under clinical …
Anita Mesić, Ine I. Decuyper, Sadiqqullah Ishaq, Taiba Azizi, Fazal Hadi Ziamal, et al.
…ll-oral rifampicin-resistant tuberculosis (RR-TB) treatment regimens showed that these are at least as effective and safer than previously used longer and injectable-containing regimens [1–4]. Findings directly informed World Health Organization (WHO) guidelines for the treatment…
Nathan Peroutka-Bigus, Michael S Scherman, Firat Kaya, Samanthi L Waidyarachchi, Jiuyu Liu, et al.
…as partner agents when used in conjunction with established regimens in mice. The Nix-TB regimen of bedaquiline, pretomanid, and linezolid represents a short, effective regimen recommended for treatment of pre-extensively drug-resistant tuberculosis. However, linezolid administra…
Yao Qin, Yuanyuan Chen, Qingshan Cai
…atment challenges, requiring effective and safe therapeutic regimens. This study aims to assess the efficacy and safety of a 24-week regimen that includes Delamanid (Dlm) for patients with these resistant forms of tuberculosis. **METHODS:** This was a single-arm, prospective, mo…
Yu. I. Feshchenko, Н.А. Литвиненко, Н.В. Гранкіна, Maryna Pogrebna, Yu.О. Senko, et al.
…ending on the composition of ITRs (individualized treatment regimens).
 Materials and methods. Тhe prospective observational study included 566 patients with MDR/preXDR-TB and XDR-TB during 2016—2020 on the scientific clinical bases of the SI «National Institute of Phthisiol…
Patil SB, Tamirat M, Khazhidinov K, Ardizzoni E, Atger M, et al.
…omise for combination in shorter, less-toxic, and effective regimens. To date, there has been no randomized, internally and concurrently controlled trial of a shorter, all-oral regimen comprising these newer and repurposed drugs sufficiently powered to produce results for pre-XDR…
Li SY, Converse PJ, Betoudji F, Lee J, Mdluli K, et al.
…the clinically successful BPaL regimen may lead to superior regimens capable of treating both drug-susceptible and drug-resistant TB more effectively and safely.
Bharath Kathi, Vubbara Anupama, Attili Sasi Kiran, Balaji Patamsetty, Gorthi Aruna, et al.
Background: Extensively drug-resistant tuberculosis (XDR TB) is a type of tuberculosis (TB) characterized by resistance to isoniazid and rifampicin, along with resistance to one of the fluoroquinolones and at least one of the second line injectable drugs. Bedaquiline is a diarylq…
Alena Skrahina, Henadz Hurevich, Sviatlana Setkina, Viatcheslav Grankov, Varvara Solodovnikova, et al.
…measures to monitor safety and effectiveness Bdq containing regimens prospectively in the countrywide cohort study. <b>Results:</b> By January 1, 2019, cumulative number of M/XDR-TB patients treated with Bdq was 763. Among 275 of them who had final treatment outcomes, 74% were ma…
Zhang Z, Cheng Z, Liu Q, Shang T, Jiang L, et al.
… extensively drug-resistant tuberculosis (XDR-TB) in longer regimens (18-20 months). However, little is known about the safety of LNZ in longer TB treatment regimens in children. Methods Here we report 31 children who received LNZ treatment for drug-resistant tuberculosis (DR-TB)…
Borah P, Deb PK, Venugopala KN, Al-Shar'i NA, Singh V, et al.
…t (MDR and XDR) Mtb strains, adverse effects of tailor-made regimens, and drug-drug interactions among anti-TB drugs and anti-HIV therapies. Thus, there is a compelling demand for newer anti-TB drugs or regimens to overcome these obstacles. Considerable multifaceted transformatio…
Г. Н. Можокина, Yu. R. Zyuzya, L. Yu. Petrova, Anastasia Samoilova, I. А. Vаsilyevа
…teria, which necessitates the strengthening of chemotherapy regimens, the use of new antimicrobial drugs, as well as poor tolerability of treatment due to the high frequency of adverse drug reactions. Combinations of fluoroquinolones, bedaquiline, and linezolid with traditional a…
Liang Fu, Huaifang Shi, Feng Sun, Wenfei Wang, Peize Zhang, et al.
… remains a major public health threat. Nine-month, all-oral regimens containing bedaquiline (Bdq) and linezolid (Lzd) have shown high cure rates, but evidence on the durability of results beyond 24 months and long-term linezolid-induced neurotoxicity is limited. **METHODS:** We …
Conradie F, Bagdasaryan TR, Borisov S, Howell P, Mikiashvili L, et al.
Background The bedaquiline-pretomanid-linezolid regimen has been reported to have 90% efficacy against highly drug-resistant tuberculosis, but the incidence of adverse events with 1200 mg of linezolid daily has been high. The appropriate dose of linezolid and duration of treatmen…
Yadav S
… finding solutions to the issues linked to the current drug regimens against drug-resistant tuberculosis. One such remarkable development is the introduction of bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM)-based regimens to fight against two of the most severe for…
Е. М. Жукова, Е. П. Мышкова
… before and after the introduction of the updated treatment regimens and express methods of microbiological diagnostics established by the Executive order #951. <b>Methods:</b> The results of treatment of patients (n=378) treated in 2014 and 2018 (years before and after the imple…
George Ikpe, Shadrach Dimang, Ufuoma Aduh, Peter Idowu Omoniyi, Ugochukwu Chukwulobelu, et al.
**INTRODUCTION:** the treatment of multidrug-resistant tuberculosis (MDR-TB) has been challenging, often associated with life-threatening adverse events and poor treatment outcomes. The recent World Health Organization (WHO) recommendation of the BPaLM regimen, consisting of beda…
Sergey Evgenievich Borisov, Alexey Filippov, I. N. Danilova, Sergey Kosenkov
<b>Background:</b> The Moscow experience in new TB drugs implementation may be considered as real-life realization of some approaches declared in the new WHO initiative (2018, August). <b>Methods:</b> Based on the city personal register for MDR TB cases formed the aggregate cohor…
Wu HY, Tian Y, Wang XD, Sun JS, Fan LC, et al.
…uate the 24-week interim outcomes of bedaquiline-containing regimens in the treatment of adolescents with rifampicin-resistant tuberculosis (RR-TB) in China. Methods Adolescents with RR-TB from two hospitals were included in this retrospective study. All patients received the lon…
Solodovnikova V, Kumar AMV, Hurevich H, Sereda Y, Auchynka V, et al.
…y and effectiveness of bedaquiline and delamanid containing regimens in children and adolescents with Multidrug-Resistant Tuberculosis (MDR-TB) and Extensively Drug-Resistant Tuberculosis (XDR-TB) globally. In this nationwide descriptive cohort study from Belarus, we examined adv…