Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis.
Nathan Peroutka-Bigus, Michael S Scherman, Firat Kaya, Samanthi L Waidyarachchi, Jiuyu Liu, Joel N Rushefsky, Michelle M Butler, Terry Bowlin, et al. (14 authors)
Antimicrobial agents and chemotherapy · 2025-11
Abstract
Spectinamides have garnered interest as experimental tuberculosis therapeutics owing to their safety profile and efficacy as partner agents when used in conjunction with established regimens in mice. The Nix-TB regimen of bedaquiline, pretomanid, and linezolid represents a short, effective regimen recommended for treatment of pre-extensively drug-resistant tuberculosis. However, linezolid administration is associated with severe adverse events that limit its use. Here we present preclinical data comparing Nix-TB regimens anchored by either linezolid or spectinamide MBX-4888A.
MeSH terms
- Animals
- Linezolid
- Antitubercular Agents
- Mice
- Mice, Inbred BALB C
- Mycobacterium tuberculosis
- Diarylquinolines
- Spectinomycin
- Female
- Disease Models, Animal
- Drug Therapy, Combination
- Nitroimidazoles
- Microbial Sensitivity Tests
- Adamantane
- Ethylenediamines