Showing 51–75 of 200 documents
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Manish K. Munda, Niranjan Kumar Sit, Rupam Kumar Ta, Dr Santanu Ghosh
Background: Drug resistance in tuberculosis is a global problem and India is no exception to this. However, this rise is mainly among the previously treated cases as previous antituberculosis therapy is the single most important risk factor for the development of drug resistance.…
Fadrian Fadrian, Khie Chen, July Kumalawati, Cleopas Martin Rumende, Hamzah Shatri, et al.
BACKGROUND: The emergence of drug-resistant pathogens (DRP) in recent years possibly contributes to the common problems associated with community-acquired pneumonia. However, to predict the risk of the ailment, the DRIP score is mainly applied, although no validation study has be…
Machado D, Lecorche E, Mougari F, Cambau E, Viveiros M
Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis , drug resistance may also result from the overactivity of efflux systems, which is mostl…
Sharma M, Roy N, Banerjee R, Kishore J, Jakhar A
Introduction Drug-resistant tuberculosis (DR-TB) is a major concern to effective control of tuberculosis (TB) in India and the likelihood of drug resistance increases with repeated exposure to anti-TB drugs. India has emerged as one of the leading contributors of DR-TB in the wor…
Amitabh Das Shukla, Mohd Zulham Affandi Mohd Zahid, Abhishek Singh
…berculosis (TB) prevalence, especially India, are facing is drug-resistant TB. Fluoroquinolones (FQs) play an essential role in treating & controlling drug-resistant tuberculosis (DR-TB). Missense mutations found within the FQ resistance-determining region of the Mycobacteria…
Guiqing He, Qingyong Zheng, Jing Wu, Jingjie Luan, Yuanfei Ji, et al.
…editions ofcomplex (MTBC) mutations catalog associated with drug resistance in 2021 and 2023, respectively. The aim of this study was to evaluate the resistance prediction by mutation catalog for nine anti-tuberculosis drugs in rifampicin (RIF)-resistant tuberculosis (RR-TB) in W…
Rubeshan Perumal, Neda Bionghi, Camus Nimmo, Marothi Letsoalo, Matthew J. Cummings, et al.
<h3>Tweetable abstract</h3> <b>Bedaquiline resistance is a major threat to drug-resistant tuberculosis control strategies. This analysis found a pooled prevalence of baseline bedaquiline resistance of 2.4% and a pooled prevalence of treatment-emergent bedaquiline resistance of 2.…
Dai E, Zhang H, Zhou X, Song Q, Li D, et al.
The emergence and spread of drug-resistant Mycobacterium tuberculosis is of global concern. To improve the understanding of drug resistance in Mycobacteria, numerous studies have been performed to discover diagnostic markers and genetic determinants associated with resistance to …
О. М. Raznatovska, V.I. Petrenko, О.S. Shalmin, R. М. Yasinskiy, A.V. Fedorec, et al.
…emporal bone tuberculosis in a patient with co-infection of drug-resistant tuberculosis/HIV infection is presented. The aim of the work was to identify risk factors, features of the clinical course, treatment and outcomes of temporal bone tuberculosis at drug-resistant tuberculos…
Kara Lukas, Madeleine T Dang, Clare Necas, Vishwanath Venketaraman
…uberculosis (TB) is a global health challenge caused bywith drug resistance, treatment toxicity, and treatment adherence challenges continuing to impede control efforts. The objective of this review is to explore current advancements in TB treatment, for both drug-sensitive and d…
Soutrik Kundu, Sarvan Singh
The incidence of drug-resistant strains of Tuberculosis (TB) is rising at an alarming rate. With the emergence of newer drug-resistant strains, managing the disease with existing antitubercular agents is becoming increasingly difficult. Few studies exist regarding the treatment o…
Dr Prasobh G.R Vishnu priya. B. P
…e, development of ADR during treatment and the evolution of drug resistance. The drugs used in treatment have a higher proportion of side effects. The majority patients required treatment modification due to ADRs. The proper identification, reporting, management, or prevention ca…
Anisa Rachmita arianti, Syamsudin Syamsudin, Ros Sumarny, Lusi Nursilawati Syamsi
…g the 10 countries contributing to the highest incidence of drug-resistant tuberculosis each year. There are 12,794 cases of drug-resistant tuberculosis in Indonesia with 7,884 cases starting treatment. The number of drug-resistant tuberculosis cases involves a variety of risk fa…
Asma Ansari, Mohammad Nadeem Khan, Shazia Mansoor
…Mycobacterium tuberculosis which is a global concern due to drug resistance. Recently there is an increase of 20% drug resistance strain of tuberculosis and some are resistant to more than one drug called multi – drug resistance tuberculosis (MDR – TB). To overcome this problem t…
Gomes LC, Campino S, Marinho CRF, Clark TG, Phelan JE
Drug resistance in Mycobacterium tuberculosis , the causative agent of tuberculosis disease, arises from genetic mutations in genes coding for drug-targets or drug-converting enzymes. SNPs linked to drug resistance have been extensively studied and form the basis of molecular dia…
Augustina Angelina Sylverken, Ellis Owusu‐Dabo, Alexander Kwarteng, Sampson Twumasi-Ankrah, Michael Owusu, et al.
…nsport providers using WhatsApp during the first nationwide drug resistance tuberculosis (TB) survey in Ghana. </ns4:p> <ns4:p> <ns4:bold>Methods:</ns4:bold> The survey was conducted between February 2016 and June 2017, and involved 33 TB diagnostic sites selected on the basis of…
Augustina Angelina Sylverken, Ellis Owusu‐Dabo, Alexander Kwarteng, Sampson Twumasi-Ankrah, Michael Owusu, et al.
…nsport providers using WhatsApp during the first nationwide drug resistance tuberculosis (TB) survey in Ghana. </ns4:p> <ns4:p> <ns4:bold>Methods:</ns4:bold> The survey was conducted between February 2016 and June 2017, and involved 33 TB diagnostic sites selected on the basis of…
Yang H, Li A, Dang L, Kang T, Ren F, et al.
…duction Mycobacterium tuberculosis (MTB) identification and drug resistance diagnosis are very important for treatment of drug-resistant tuberculosis (DR-TB). Therefore, high throughput, accurate and low-cost molecular detection techniques are urgently needed. This study aimed to…
Jeon SM, Park S, Lim NR, Lee N, Jung J, et al.
Rapid and accurate detection of tuberculosis (TB) drug resistance is critical for the successful treatment and control of TB. Here, we investigated resistance to anti-TB drugs and genetic variations in 215 drug-resistant Mycobacterium tuberculosis isolates in Korea. Genetic varia…
Zhenyu Liu, Huoying Chen, Lijun Xiong, Di Wang, Guifen Zeng, et al.
Abstract Purpose To better understand the distribution and drug resistance of Klebsiella pneumoniae and provide a basis for clinical treatment. Methods We studied 167 Klebsiella pneumoniae clinical specimens in the Second Affiliated Hospital of Guilin Medical University from Nove…
Song S, Xu H, Cao J, Wu G, Sun H, et al.
…osis (TB) caused by Mycobacterium tuberculosis (MTB)and its drug resistance. This study aimed to compare the ability of nucleotide MALDI-TOF MS to detect rifampicin (RIF) resistance in drug-resistant TB (DR-TB) patients with Xpert MTB/RIF and to analyze the disparate results indi…
Jahn LJ, Simon D, Jensen M, Bradshaw C, Ellabaan MMH, et al.
…sidered a relevant strategy to tackle the global antibiotic resistance crisis since they are believed to increase treatment efficacy and reduce resistance evolution (WHO treatment guidelines for drug-resistant tuberculosis: 2016 update.). However, studies of the evolution of bact…
Ayalew S, Wegayehu T, Taye H, Wassie L, Girma S, et al.
… limited information available on gene mutations conferring drug resistance and genetic diversity of M. tuberculosis isolates from TBLN patients. Methods Drug resistance and genetic diversity analysis were done on 91 M. tuberculosis isolates from culture positive TBLN patients co…
Berríos-Caro E, Gifford DR, Galla T
…ave shown remarkable success in preventing the evolution of resistance to multiple drugs, including HIV, tuberculosis, and cancer. Nevertheless, the rise in drug resistance still remains an important challenge. The capability to accurately predict the emergence of resistance, eit…
Zaniani FR, Moghim S, Esfahani BN
Background Increasing drug resistance is an important factor in the complexity of tuberculosis (TB) control. The identification of disease transmission type, recurrence of a previous infection, or new transmission of the disease is the key factor in the control of TB. In this stu…