Showing 51–75 of 200 documents
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Pan SW, Su WJ, Chan YJ, Chuang FY, Feng JY, et al.
Objectives The timely diagnosis of pulmonary tuberculosis (PTB) is challenging. Although pathogen-derived circulating cell-free DNA (cfDNA) has been detected in humans, the significance of Mycobacterium tuberculosis (MTB)-cfDNA detection in patients with PTB remains unclear. Meth…
Dipali Maganbhai Gavali, Binita Aring, Hiral Gadhavi, Akhlakahemad Nathamehta, Abhishek B Dave, et al.
… high prevalence in India, accounting for one-fourth of the Tuberculosis (TB) cases in the world. In our study, we aimed to find the prevalence of Pre XDR-TB and XDR-TB amongst newly diagnosed cases of pulmonary MDR-TB who had never been previously treated with second-line drugs.…
Luo Y, Xue Y, Mao L, Lin Q, Tang G, et al.
…ackground Rapid and effective discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains a challenge. There is an urgent need for developing practical and affordable approaches targeting this issue. Methods Participants with ATB and LTBI wer…
Dekel Shlomi, Inbal Galor, Anna More, Bernice Oberman, Lizi Fireman
<b>Background:</b> Treatment for latent tuberculosis (TB) is traditionally based on the result of the tuberculin skin test (TST) which is often falsely positive. The Interferon gamma release assays (IGRA) are more specific but considerably more expensive. Several studies have imp…
Lifan Zhang, Huimin Ma, Qiping Ge, Yueqiu Zhang, Xiaochun Shi, et al.
Abstract Background To establish the Mycobacterium tuberculosis (MTB) specific IFN-γ/IL-2/TNF-α-FluoroSpot assay, and preliminarily evaluate its accuracy of differential diagnosis of active tuberculosis (ATB) and latent tuberculosis infection (LTBI). Methods Patients with patholo…
D. S. Esmedlyaevа, Н. П. Алексеева, Marina Dyakova
…of adverse treatment outcomes in individuals with pulmonary tuberculosis (PT) is relevant due to the worldwide increase in drug resistance of Mycobacterium tuberculosis (MBT) strains to anti-tuberculosis drugs (PTP). Matrix metalloproteinases (MMPs) and their tissue inhibitors (T…
World Health Organization
This web annex to the WHO consolidated guidance on tuberculosis data generation and use presents the second edition of the checklist for assessing tuberculosis (TB) surveillance and vital registration systems. The document aims to support countries in evaluating whether their sur…
Pereira AHB, Lopes CAA, Pissinatti TA, Pinto ACA, Oliveira DRA, et al.
… pathology of monkeys naturally infected with Mycobacterium tuberculosis complex from five different colonies in Rio de Janeiro, Brazil. On the basis of gross and histopathological findings, the lesions were classified into chronic-active, extrapulmonary, early-activation or late…
Abebe F, Belay M, Legesse M, K L M C F, Ottenhoff THM
…nvestigate protective and diagnostic immune markers against tuberculosis (TB), we measured antibody isotype responses to Mycobacterium tuberculosis (Mtb) antigens (LAM, Rv2031, and HBHA) in cohorts of 149 pulmonary tuberculosis patients (PTBP), 148 household contacts (HHCs), and …
Zhang L, Li Y, Zou X, Ma H, Gao M, et al.
…aims to evaluate the diagnostic accuracy of a Mycobacterium tuberculosis (MTB)-specific triple-color FluoroSpot assay (IFN-γ/IL-2/TNF-α) in the differentiation of tuberculosis (TB) infection status in febrile patients. Method Febrile patients with suspected active TB (ATB) were c…
Shaohua Yao, Yan Jy, Li L, Daqing Ma, Jun Liu, et al.
…Wang,1 Aimin Wang,1 Fangjin Bao,1 Zekun Zhang,1 Xundi Bao1 1Tuberculosis Prevention and Treatment Institute of Anhui Province (Anhui Chest Hospital), Hefei 230022, Anhui, People’s Republic of China; 2Affiliated Psychological Hospital of Anhui Medical University, Hefei Fourt…
幸作 小宮
…e advanced age is a main prognostic factor in patients with tuberculosis, the factors that specifically affect tuberculosis-related death are unclear because elderly people are at a risk for other age-related lethal diseases.We hypothesized that performance status, a prognostic f…
World Health Organization
This web annex to the WHO consolidated guidance on tuberculosis data generation and use summarizes the findings of a retrospective evaluation of the WHO DHIS2 case-based package for tuberculosis surveillance, known as the “TB tracker”, implemented in five pilot countries: Ghana, …
Organización Mundial de la Salud
…ía consolidada de la OMS sobre generación y uso de datos de tuberculosis resume los hallazgos de una evaluación retrospectiva del paquete de vigilancia de tuberculosis basado en casos de la OMS en DHIS2, conocido como “TB tracker”, implementado en cinco países piloto: Ghana, la R…
Jorwal P, Singh BK, Anand A, Khan F, Khandelwal K, et al.
Background Tuberculosis (TB) is still the second causative agent of death worldwide after COVID-19. It is caused by Mycobacterium tuberculosis (MTB) infection. Objective The aim of the current study was to compare the performance of GeneNAT real-time polymerase chain reaction ana…
Karaca C, Ozer F, Sevim DG, Erdoğan O, Unlu M
We present a case series of eight patients with ocular tuberculosis (OTB), latent tuberculosis (TB) or sarcoidosis, some of whom were receiving anti-tumor necrosis factor alpha (anti-TNF-α) therapy for various systemic diseases. Only one patient had a positive QuantiFERON®-TB tes…
Teklu T, Wondale B, Taye B, Hailemariam M, Bekele S, et al.
Background Tuberculosis (TB) is one of the world's most problematic infectious diseases. The pathogen Mycobacterium tuberculosis (Mtb) is contained by the immune system in people with latent TB infection (LTBI). No overt disease symptoms occur. The environmental and internal trig…
Dejene TA, Hailu GG, Kahsay AG, Wasihun AG
Introduction Tuberculosis (TB) is the second leading cause of mortality from an infectious disease worldwide. Multidrug-resistant tuberculosis (MDR-TB), where rifampicin-resistant TB is the biggest contributor, remains a global health threat. There is scant data on MTB and rifamp…
Anuradha Kalotra, Dinesh Kumar, Ravi Kumar, Arvind Kumar Yadav, Kiran Lachala, et al.
Background: Tuberculosis (TB) patients suffer enormously due to huge cost on diagnosis and treatment. This study aims to assess the total expenditure and its predictors among patients of TB. Methodology: A longitudinal study was conducted among TB Patients registered in first qua…
Téllez-Navarrete NA, Ramon-Luing LA, Muñoz-Torrico M, Preciado-García M, Medina-Quero K, et al.
Background Tuberculosis (TB) is an infectious disease. During TB, regulatory T cells (Treg) are related to poor prognosis. However, information about conventional and unconventional Treg (cTreg and uTreg, respectively) is limited. The tumour necrosis factor (TNF) and its receptor…
Luo Y, Xue Y, Lin Q, Tang G, Yuan X, et al.
Background Discriminating active tuberculosis (ATB) from latent tuberculosis infection (LTBI) remains challenging. This study aimed to investigate a diagnostic model based on a combination of iron metabolism and the TB-specific antigen/phytohemagglutinin ratio (TBAg/PHA ratio) in…
Oudghiri A, Karimi H, Chetioui F, Zakham F, Bourkadi JE, et al.
Background The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global TB control. Although multi drug-resistant tuberculosis (MDR- TB) prevalence and associated genetic mutations in Morocco are well documented, scarce information…
Arroyo L, Marín D, Franken KLMC, Ottenhoff THM, Barrera LF
Background Tuberculosis (TB) remains one of the most deadly infectious diseases. One-third to one-fourth of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb) without showing clinical symptoms, a condition called latent TB infection (LTBI). Dia…
Luo Y, Tang G, Lin Q, Mao L, Xue Y, et al.
Objectives Distinguishing between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. Methods The modified T-SPOT.TB assay was performed in 499 participants (243 ATB and 256 LTBI) and another 322 participants (162 ATB and 160 LTBI) who were dia…
Goletti D, Delogu G, Matteelli A, Migliori GB
…arter of the global population is infected by Mycobacterium tuberculosis (Mtb). A better control of tuberculosis (TB) is based on the ability to detect Mtb infection, identifying the progressors to TB disease, undergoing to preventive therapy and implementing strategies to regist…