Showing 26–50 of 103 documents
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С. Н. Жданова, Anna Vyazovaya, I. B. Lebedeva, V. V. Sinkov, И. Г. Кондратов, et al.
…acterized by a high prevalence of multidrug-resistant (MDR) tuberculosis (TB), including coinfection with HIV (HIV/TB). A previously unknown in Russia relationship between MDR and the Beijing Central Asian Outbreak (CAO) subtype has been discovered, which updates studies of Mycob…
Rajesh Kumar Yadav, Hari Prasad Kaphle, Dipendra Kumar Yadav, Suman Chandra Gurung, Elina Khatri, et al.
…ance among TB patients. The emergence of resistance to anti-tuberculosis drugs and particularly of multi-drug resistance (MDR), Pre-extensively drug resistance tuberculosis (Pre-XDR) and extensively drug resistance (XDR) tuberculosis have become a major public health problem in s…
Sarmat Z. Suleimanov, M. V. Sinitsyn, I. V. Golubenkov, L. E. Parolina, O. V. Lovаchevа, et al.
…to compare the spectrum of drug resistance of Mycobacterium tuberculosis obtained from respiratory and surgical specimens of pulmonary tuberculosis patients. Subjects and Methods . A non-randomized, continuous, single-center retrospective study was performed and included 102 pati…
Radhika R, Tullu MS, Shamla O, David J
Abstract Tuberculosis as cause of mediastinal mass, is rare in children, and may be seen in immunodeficiencies. Data on the prevalence of mediastinal tuberculosis and on its clinical spectrum and outcome is lacking in children. A 4.5-month-old boy presented with fever and cough s…
Jain P, Singh U, Kumar V, Ratnam R, Jain A
…the WHO as the screening test for diagnosing extrapulmonary tuberculosis (EPTB). In the present study we report the agreement between CBNAAT (Xpert MTB/RIF), liquid culture (LC) and line probe assay (LPA) for diagnosis of Mycobacterium tuberculosis and detection of drug resistanc…
Breli Bonheur Ngouama, Jean Claude Djontu, Darrel Ornelle Elion Assiana, Freisnel Hermeland Mouzinga, Mita Naomie Merveille Dello, et al.
**BACKGROUND:** WHO strategy to end Tuberculosis (TB) calls for drug susceptibility testing of Mycobacterium tuberculosis (MTB) for all patients, in high TB burden settings. Thus, this study aimed to investigate the MTB drug resistance profiles and related risk factors among pati…
R Santosh
Introduction: Drug-resistant tuberculosis is a major public health problem throughout world. India accounts for 27% of global TB burden. More than half of TB patients in India are cared for in private sector. Usage of inappropriate TB diagnostic, treatment practices and lack of a…
Dana Auganova, Sabina Atavliyeva, Nour Gharbi, Elena Zholdybayeva, Yuri Skiba, et al.
… data on the genomic diversity of circulating Mycobacterium tuberculosis strains in Kazakhstan remains limited. We performed whole-genome sequencing on 177 clinical M. tuberculosis isolates belonging to the L2/Beijing lineage, sourced from 15 regions across Kazakhstan. WGS data w…
Julia Bespyatykh
According to the WHO, tuberculosis morbidity remains high, despite a trend towards stabilization the situation remains extremely tense due to the distribution of resistant forms. The aim of the present study was to use omics approaches to detect changes in M. tuberculosis strains…
R. V. Tarasov, Л. Н. Лепеха, S. S. Sаdovnikovа, E. V. Krаsnikovа, D. S. Barkova, et al.
…reatment of a patient with widespread destructive pulmonary tuberculosis with preXDR MBT against the background of severe bullous lung dystrophy after prolonged exogenous exposure to fine particles of coal dust in the anamnesis. Patient M., 42 years old, smoker, has been working …
Liang D, Song Z, Liang X, Qin H, Huang L, et al.
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis ( Mtb ), is a major public health issue in China. Nevertheless, the prevalence and drug resistance characteristics of isolates vary in different regions and provinces. In this study, we investigated the population…
Kostyukova I, Pasechnik O, Mokrousov I
Russia is a high-burden area for multidrug-resistant tuberculosis (MDR-TB). Here, we studied the epidemiological situation and drug resistance patterns of Mycobacterium tuberculosis in the Omsk region in Western Siberia. M. tuberculosis isolates ( n = 851) were recovered from new…
Fernandez Do Porto DA, Monteserin J, Campos J, Sosa EJ, Matteo M, et al.
…nd Whole-genome sequencing has shown that the Mycobacterium tuberculosis infection process can be more heterogeneous than previously thought. Compartmentalized infections, exogenous reinfections, and microevolution are manifestations of this clonal complexity. The analysis of the…
Morey-León G, Andrade-Molina D, Fernández-Cadena JC, Berná L
Background Tuberculosis is a serious infectious disease affecting millions of people. In spite of efforts to reduce the disease, increasing antibiotic resistance has contributed to persist in the top 10 causes of death worldwide. In fact, the increased cases of multi (MDR) and ex…
Zhdanova S, Jiao WW, Sinkov V, Khromova P, Solovieva N, et al.
…pic and genotypic drug resistance patterns of Mycobacterium tuberculosis strains from children with tuberculosis (TB) in China and Russia, two high-burden countries for multi/extensively-drug resistant (MDR/XDR) TB. Whole-genome sequencing data of M. tuberculosis isolates from Ch…
Linhares LA, Dos Santos Peixoto A, Correia de Sousa LA, Lucena Laet JP, da Silva Santos AC, et al.
Tuberculosis remains a major public health problem and one of the top ten causes of death worldwide. The alarming increase in multidrug-resistant and extensively resistant variants (MDR, pre-XDR, and XDR) makes the disease more difficult to treat and control. New drugs that act a…
Ulan Kozhamkulov, Asset Daniyarov, Ainur Akhmetova, Saule Rakhimova, Zhannur Abilova, et al.
In Kazakhstan, the total incidence rate of tuberculosis in 2021 was 74 cases per 100,000 population. The aim of this study was the characterization of drug-resistant (DR) <i>M. tuberculosis</i> (MTB) collected in Kazakhstan and to perform pilot whole genome sequencing for drug re…
Igor Mokrousov, Anna Vyazovaya, Neliya Vasilieva, Regina Mudarisova, Natalia Solovieva, et al.
…erm treatment. To gain molecular insight into Mycobacterium tuberculosis variation during long-term observation and treatment of chronic tuberculosis (TB) patients. The retrospective study enrolled nine tuberculosis patients who had multiple episodes of receiving anti-TB chemothe…
С. Н. Жданова, М. К. Винокурова, И. Г. Кондратов, Н. Е. Евдокимова, V. V. Sinkov, et al.
…he Republic of Sakha (Yakutia) since 2020, the incidence of tuberculosis (TB) has become lower than the Russian average against the background of an increase in the proportion of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, including among new cases. Objec tiv…
С. Н. Жданова, И. Г. Кондратов, О. Б. Огарков
…aintains a high incidence rate of multidrug-resistant (MDR) tuberculosis (TB). Detection of MDR-associated Mycobacterium tuberculosis strains in Irkutsk region requires dynamic assessment of the TB pathogen population, taking into account the emergence of a new resistant variant …
S. V. Sklyuev, Е. М. Жукова, N. V. Stavitskaya
…cal case of a female patients with the continuous course of tuberculosis (more than 14 years). Despite the ongoing anti-tuberculosis therapy, the use of all possible surgical methods including valvular bronchial blocking, bacterial excretion persisted, fibrous cavernous tuberculo…
Dana Auganova, Sabina Atavliyeva, Aygulya Akisheva, Anna Tsepke, Pavel Tarlykov
Tuberculosis remains a highly contagious infection, with an estimated annual transmission of about 10 million people globally, as reported in the latest Global Tuberculosis Report by the World Health Organization (WHO). The primary objective of this research is to determine the g…
Ushtanit A, Mikhailova Y, Krylova L, Grigorash D, Makarova M, et al.
The emergence of drug-resistant tuberculosis forced the development of new drugs and the screening of more effective or less toxic analogues. Mycolic acid biosynthesis is targeted by several antituberculosis drugs, isoniazid being one of the most important in tuberculosis therapy…
Renji S, Solomon R, Wankhade D, Udani S, Udani V
…children admitted in our PICU with bacteriologically proven tuberculosis (smear, culture, poly-merase chain reaction, genotypic testing or Pyrosequencing) between January, 2007 and December, 2019 were retrieved. Drug resistance was classified as per World Health Organization defi…
Ghosh A, Biswas VK, Bal HB, Das D, Pati S, et al.
…ng has been used to investigate the genomic diversity of M. tuberculosis in the northern and southern states of India, but information about the eastern part of the country is still limited. Through a sequencing-based strategy, this study seeks to comprehend the diversity and dru…