Showing 1–25 of 103 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Irina Kostyukova, Anna Vyazovaya, О. А. Пасечник, Igor Mokrousov
Background . The prevalence of multidrug-resistant tuberculosis poses a serious public health problem, hampering the success of tuberculosis control programs around the world. Aim : Evaluation of epidemiological manifestations of tuberculosis and molecular genetic characteristics…
Yang Che, Tianfeng He, Lin Lyu, Ping Guo-hua
…bjective To analyze the characteristics of second-line anti-tuberculosis (TB) drugs resistance and gene mutation of multidrug-resistant (MDR) Mycobacterium tuberculosis isolated in Ningbo. Methods In 1597 M. tuberculosis isolates collected in the first drug resistance survey in N…
Namburete E
Abstract Background Knowing the genetic diversity of M. tuberculosis strains causing drug-resistant tuberculosis (DR-TB) in high burden TB and low resources countries such as Mozambique is a key factor to TB disease spread control and world TB epidemic control. Whole-genome seque…
O. A. Zhurilo, А. І. Barbova, L.B. Skokluk, O. V. Chernov
…le presents the experience of whole-genome sequencing of M. tuberculosis (MBT) strains. Materials and methods. 8 MBT isolates were tested. The strains were obtained from patients with newly detected pulmonary tuberculosis (NDPTB). Critical concentrations of anti-mycobacterial dru…
Jun Ma, Lin Fan, Hongcheng Liu, Wenting Li, Wenwen Sun
…global burden of Rifampicin Resistance ／Multidrug-Resistant tuberculosis (RR/MDR-TB) and low HIV incidence. Our aim was to assess the epidemiological and clinical characteristics of RR/MDR-extrapulmonary tuberculosis (EPTB) over the past five years in China to inform national TB …
Yu. D. Mikhailova, Marina Makarova, L. Yu. Krylova, S. G. Safonova, В. И. Литвинов
Due to the widespread drug resistance of M. tuberculosis (MTB), it is necessary to assess the possibility of using drugs with antimycobacterial activity previously used in other pathologies, e.g. clofazimine, in anti-tuberculosis chemotherapy regimens. The aim was to determine th…
Podlekareva DN, Folkvardsen DB, Skrahina A, Vassilenko A, Skrahin A, et al.
Background To cure drug-resistant (DR) tuberculosis (TB), the antituberculous treatment should be guided by Mycobacterium tuberculosis drug-susceptibility testing (DST). In this study, we compared conventional DST performed in Minsk, Belarus, a TB DR high-burden country, with ext…
M K Wijayanto, J Juniastuti, R Yudhawati, D Handayani
Abstract Rationale Tuberculosis (TB) remains a major global health challenge, affecting an estimated 10.8 million people worldwide. Indonesia ranks second globally in TB burden, with approximately one million cases annually. The prevalence of drug-resistant (DR) TB is also among …
DK Mumena, Geoffrey Kwenda, CW Ngugi, AK Nyerere
Background: Drug-Resistant Tuberculosis (DR-TB) is one of the major public health issues globally. Zambia is highly burdened by TB and multi-drug resistant TB. In this study, sputum samples obtained from the new and previously treated cases of TB were examined for drug-resistant …
Conceição EC, Loubser J, Guimarães AEDS, Sharma A, Rutaihwa LK, et al.
… Pará, Northern Brazil, described a strain of Mycobacterium tuberculosis with a unique genotype (SIT2517/T1) associated with multidrug-resistant tuberculosis (MDR-TB). To improve our understanding of MDR-TB transmission dynamics of these strains within this region, we performed p…
Pinhata JMW, Brandao AP, Mendes FF, Rabello MCDS, Ferrazoli L, et al.
…and isoniazid phenotypic resistance levels in Mycobacterium tuberculosis isolates from drug-resistant TB patients from São Paulo state, Brazil. Isolates resistant to the critical concentration of isoniazid in MGIT (0.1 µg/mL) were screened for mutations in katG 315 codon, inhA pr…
Zhang X, Chen X, Wang B, Fu L, Huo F, et al.
…olones (FQs) are the cornerstone in treating drug-resistant tuberculosis (TB); the prevalence of TB among the population is diverse in different regions, understanding the relationship between resistance pattern and molecular characteristic of FQs in preextensive drug-resistant (…
О. А. Пасечник, Anna Vyazovaya, A. I. Bloch, Irina Yarusova, M. P. Tatarintseva, et al.
…nce. The spread of the epidemic and resistant Mycobacterium tuberculosis genotypes presents a serious threat to the implementation of the national tuberculosis control program in Russia. The study aimed to assess the trends in the development of the epidemic process of tuberculos…
Dagne B, Desta K, Fekade R, Amare M, Tadesse M, et al.
Background Drug-resistance in Mycobacterium tuberculosis complex remains a major health burden in human history and still is a major leading cause of death in developing countries including Ethiopia. Early detection of all forms of drug-resistant Tuberculosis(TB) is a key factor …
Kamal Ahmadi, Nahid Madadi-Goli, M Masoumi, Mahshid Nasehi, Seyed Davar Siadat, et al.
Introduction: Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most common infectious diseases worldwide. Epidemiological studies of M. tuberculosis drug resistance are critical for improving patient treatment approaches and controlling the spread of tuberculosis…
Ismail NA, Omar SV, Moultrie H, Bhyat Z, Conradie F, et al.
…nts with rifampicin-resistant and multidrug-resistant (MDR) tuberculosis; however, emerging resistance threatens this success. We did a cross-sectional and longitudinal analysis evaluating the epidemiology, genetic basis, and treatment outcomes associated with bedaquiline resista…
Diriba G, Kebede A, Tola HH, Alemu A, Yenew B, et al.
Background In Ethiopia, tuberculosis (TB) is one of the most common causes of illness and death. However, there is limited information available on lineages associated with drug resistance among extrapulmonary tuberculosis patients in Ethiopia. In this study, researchers looked i…
Richmond Ronald Gomes
…enitis is the most frequent extrapulmonary manifestation of tuberculosis infection. There are limited documents on multidrugresistant cervical tubercular lymphadenitis, but there is no evidence which may occur in TB endemic regions. Multidrug-resistant tuberculosis (MDR-TB) occur…
Ángel de Jesús Dzul-Beh, Karlina García‐Sosa, Andrés Humberto Uc‐Cachón, Jorge Bórquez, Luis Loyola, et al.
…th those reported in the literature. The anti-Mycobacterium tuberculosis activity of spathulenol was evaluated on MDR, pre-XDR, and XDR clinical isolates of M. tuberculosis, as well as on the reference susceptible strain H37Rv and its cytotoxic activity was evaluated on the Vero …
Marie José Bajani Kabedi, Steve Ahuka, Octavie Metila Lunguya, Jean Marie Kayembe, Hippolyte Nani Tuma Situakibanza, et al.
…Republic of the Congo, children are likely to be exposed to tuberculosis (TB) through close contact. Failure to diagnose can have devastating consequences. The objective of the present study was to determine the frequency of TB and the primary resistance of Mycobacterium tubercul…
Anusmriti Pal, Tanka Acharya, Kamal Hamal, Nanda Acharya, Khadga Bikram Shah
Introduction: Tuberculosis is a global health concern, and its prevalence can vary widely from one region to another. Factors such as altitude, climate, population density, and healthcare infrastructure can all influence the dynamics of Tuberculosis in a particular area. This stu…
А. В. Мордык, О. Г. Иванова, S. V. Sitnikova, V. I. Gusina, A. O. Ptukhin
…tment of newly diagnosed patients, including HIV-associated tuberculosis, with the mandatory inclusion of new anti-tuberculosis drugs in the treatment regimens of patients. drugs. Aim . To evaluate the efficacy and safety of bedaquiline in the complex treatment of patients with H…
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
Bhosale S, Prabhakar A, Srivastava S, Raj A, Purohit S, et al.
…ign Retrospective observational analysis. Objectives Spinal tuberculosis accounts for about 50% of cases among extra pulmonary osteoarticular tuberculosis. Resistance to drugs in spinal tuberculosis patients is on a rise and there is inadequate literature concentrating on the pre…
Sofya Andreevskaya, Е. Е. Ларионова, Ekaterina A. Kiseleva, Л. Н. Черноусова, Atadzhan Ergeshov
…to evaluate changes in detection frequency of Mycobacterium tuberculosis of the main phylogenetic lines with various genetic determinants of resistance to rifampicin, isoniazid and fluoroquinolones in 1998–2003 and 2016–2021. Subjects and Methods. 965 mycobacterial cultures were …