Showing 26–50 of 200 documents
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Per Bjorkman, M.D., Ph.D.
Background: Tuberculosis (TB) and HIV are leading causes of disease and death in Subsaharan Africa. Antiretroviral therapy (ART) dramatically improves prognosis in HIV infection, but TB is still a common complication in HIV-infected subjects. Management of TB-HIV co-infection is …
Mihir P. Rupani, Sheetal Vyas
…ctors of catastrophic costs due to TB among co-prevalent TB-HIV and TB-diabetes patients. Methods: We conducted a cross-sectional study among 234 patients co-affected with TB-HIV and 304 patients with TB-diabetes co-prevalence in the Bhavnagar region (western part of India). TB c…
Yalemzewod Assefa Gelaw
…er of the global burden of TB. This is associated with high HIV-prevalence, low socio-demographic development, and poor living and working conditions. Identification of high-risk populations and locations within countries with a high burden of TB has the potential to improve the …
Surendra K Sharma, M.D., Ph.D
HIV induced altered representation and function of regulatory T cell subsets (NKT and Treg cells) impair the protective T cell response against M.tuberculosis and disrupts LTBI, thus facilitates faster progression and development of severe forms of clinical TB in HIV-TB co-infect…
Goovaerts O, Massinga-Loembé M, Ondoa P, Ceulemans A, Worodria W, et al.
…ed immune reconstitution inflammatory syndrome (TB-IRIS) in HIV-TB co-infected patients receiving antiretroviral therapy (ART) has been linked to neutrophil activation. Anti-neutrophil cytoplasmic antibodies (ANCAs) are also associated with neutrophil activation. Since ANCAs are …
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
TB-Speed HIV is a prospective multicentre management study evaluating the safety and feasibility of the recently proposed PAANTHER TB treatment decision algorithm for HIV-infected children with presumptive TB. It will be conducted in four countries with high and very high TB (Tub…
Shun-Xian Zhang, Jin-Xin Zheng, Yu Wang, Wen-Wen Lv, Jian Yang, et al.
…e years (DALYs) for TB from 1990 to 2021. Over this period, HIV-negative TB showed a marked decline in ASIR (AAPC = -2.34%, 95% CI: -2.39, -2.28) and ASMR (AAPC = -0.56%, 95% CI: -0.62, -0.59). Specifically, drug-susceptible TB (DS-TB) showed reductions in both ASIR and ASMR, whi…
Lusiana R Idrus, Master
…tionale: The co-infection of human immunodeficiency virus (HIV) and tuberculosis (TB) diseases presents further problems to patient's adherence due to high pill burden and adverse effects in the drug combination therapy. This situation is also a risk of the increase of multi-dru…
Granich R, Gupta S
Purpose of review The HIV and Mycobacterium tuberculosis syndemic remains a major global public health threat. HIV and tuberculosis (TB) global targets have been set. Success will depend on achieving combined disease control. We explore current policy, economic investment, and di…
Fernandez D, Salami I, Davis J, Mbah F, Kazeem A, et al.
Objective HIV and tuberculosis represent diseases of major public health importance worldwide. Very little is known about HIV-TB coinfection among pregnant women, especially from industrialized settings. In this study, we examined the association between TB, HIV, and HIV-TB coinf…
Waleed MD Gamal Elddin Khaleel, Ass. Prof.
People Living with HIV (PLHIV) are prone to several opportunistic infections depending on the degree of immunosuppression as well as infections prevalent in their geographic area/country. These include a wide variety of mycobacterial diseases, fungal infections, bacterial pneumon…
Md Abdul Kuddus, Sazia Khatun Tithi, Anip Kumar Paul, Thitiya Theparod
…tion of Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) remains a significant public health challenge both in Thailand and globally. This dual burden exacerbates disease severity, complicates treatment strategies, and increases mortality rates. In this study, we develope…
Mihir P. Rupani, Sheetal Vyas
…ssaving employed and enablers perceived by patients with TB-HIV, patients with TB-diabetes, and program managers of TB. Methods: We conducted qualitative in-depth interviews among eight TB-HIV patients, eight TB-diabetes patients, and seventeen program managers of TB in the Bhavn…
Tamene W, Abebe M, Wassie L, Mollalign H, Bauer K, et al.
…tion with PD1 is implicated in immune dysfunction in TB and HIV. The expression of PDL1 on multiple subsets of monocytes as well as their associations with cytokines and microbial products have not been well studied. Method HIV (TB-HIV+), TB (TB+HIV-) and TB/HIV co-infected (TB+H…
Rupani MP, Vyas S, Shah IA
…etermine the association between catastrophic costs from TB-HIV and TB-diabetes care and unfavorable TB treatment outcomes. Methods We conducted a cohort study in Bhavnagar, India, from July 2019 to January 2021, involving 234 TB-HIV and 304 TB-diabetes patients. Catastrophic cos…
Li Q, Wang C, Gou J, Kitanovski S, Tang X, et al.
…eading cause of mortality among individuals coinfected with HIV, characterized by progressive pulmonary inflammation. Despite TB's hallmark being focal granulomatous lung lesions, our understanding of the histopathological features and regulation of inflammation in HIV & TB coinf…
John C. Mgogwe, Jaffu Otheniel Chilongola
…nt tuberculosis (MDR-TB) with human immunodeficiency virus (HIV) immunologic state which is marked by chemokine and cytokine distortion is indicated by boosting the defense stimulation to a patient. The effect of coexisting infections on the MDR-TB patient with HIV is still not f…
VINA LUSIANA
…an Immunode_ciency Virus/Acquired Immuno-deciency Syndrome (HIV/AIDS) are major burden of infectious diseases in developing countries. TB and HIV infection have the effect of deeply on assault the immune system, since they can afford to weaken host immune respone through a mechan…
MacPherson P, Webb EL, Kamchedzera W, Joekes E, Mjoli G, et al.
Background Suboptimal tuberculosis (TB) diagnostics and HIV contribute to the high global burden of TB. We investigated costs and yield from systematic HIV-TB screening, including computer-aided digital chest X-ray (DCXR-CAD). Methods and findings In this open, three-arm randomis…
Gengiah S, Naidoo K, Mlobeli R, Tshabalala MF, Nunn AJ, et al.
Introduction In South Africa, mortality rates among HIV-TB coinfected patients are among the highest in the world. The key to reducing mortality is integrating HIV-TB services, however, a generalizable implementation method and package of tested change ideas to guide the scale-up…
Li L, Abudureheman Z, Zhong X, Gong H, Yang F, et al.
…nts who are coinfected with human immunodeficiency virus 1 (HIV) and Mycobacterium tuberculosis (TB) benefit from timely diagnosis and treatment. In the present study frequencies of CD3 + , CD4 + , and CD8 + T cells among peripheral blood mononuclear cells (PBMCs) of patients in …
Li L, Abudureheman Z, Zhong X, Gong H, Yangfan, et al.
…nts who are coinfected with human immunodeficiency virus 1 (HIV) and Mycobacterium tuberculosis (TB) benefit from timely diagnosis and treatment. In the present study frequencies of CD3⁺, CD4⁺, and CD8⁺ T cells among peripheral blood mononuclear cells (PBMCs) of patients in the K…
Vannesa Yue May Teng, Yan Ting Chua, Eunice En Ni Lai, Shilpa Mukherjee, Jessica Michaels, et al.
…TRACT Objectives Tuberculosis (TB) is a common infection in HIV patients. Our study aims to determine the prevalence and characteristics of HIV-TB co-infected patients in Singapore, a high-income, intermediate TB-burden country. Methods Retrospective data of 11-years was obtained…
Balfour A, Schutz C, Goliath R, Wilkinson KA, Sayed S, et al.
…l numbers generally decrease in patients with active TB and HIV infection, but findings regarding functional changes differ. Methods: We conducted a cross-sectional study on the effect of HIV, TB, and HIV-associated TB (HIV-TB) on MAIT cell frequencies, activation and functional …
Taya Rizki Arini Harahap, Tambar Kembaren, Endang Sembiring
…ulmonary TB. Aim: To assess difference in survival rates of HIV patients with pulmonary TB and extra pulmonary TB. Results: Based on Fisher's Exact test, it was found that there was no statistical difference survival rates of HIV patients with pulmonary TB and extra-pulmonary TB …