Showing 26–50 of 200 documents
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Julian Surey, Helen R. Stagg, Thomas A Yates, Marc Lipman, Peter J White, et al.
…(LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety…
Surey J, Stagg HR, Yates TA, Lipman M, White PJ, et al.
…(LTBI) to prevent future cases. Promising trials of shorter regimens have shown them to be effective as preventative TB treatment, however there is a paucity of data on self-administered treatment completion rates. This pilot trial assessed treatment completion, adherence, safety…
Borisov AS, Bamrah Morris S, Njie GJ, Winston CA, Burton D, et al.
…that 3HP is as safe and effective as other recommended LTBI regimens and achieves substantially higher treatment completion rates. In July 2017, the Work Group presented the meta-analysis findings to a group of TB experts, and in December 2017, CDC solicited input from the Adviso…
Campos-Outcalt
… for Disease Control and Prevention detail 3 shorter-course regimens that take no more than 4 months. In this month’s audiocast, Dr. Campos-Outcalt describes the regimens and who should be screened for TB.
Cao X, Guo T, Xin H, Du J, Yang C, et al.
Purpose Several model studies suggested the implementation of latent tuberculosis infection (LTBI) testing and treatment could greatly reduce the incidence of tuberculosis (TB) and achieve the 2035 target of the "End TB" Strategy in China. The present study aimed to evaluate the …
Sabella-Jiménez V, Hoyos Mendez Y, Benjumea-Bedoya D, Estupiñán-Bohorquez AF, Acosta-Reyes J, et al.
…ge. Alternatives to isoniazid, such as rifamycin containing regimens, should be considered for prophylaxis. Previous systematic reviews, with different study designs and data combining results on children and adults, have evaluated the comparative efficacy and harms of LTBI treat…
Lin SY, Feng JY, Lee CY, Lin YC, Chou YH, et al.
Although patients with end-stage renal disease receiving maintenance hemodialysis are at high risk for tuberculosis, the optimal treatment regimen for latent tuberculosis infection (LTBI) in this group has scarcely been studied for predictors of completion rate and adverse drug e…
Apriani L, Koesoemadinata RC, Bastos ML, Wulandari DA, Santoso P, et al.
BACKGROUND: The implementation of tuberculosis preventive treatment (TPT) is challenging especially in resource-limited settings. As part of a Phase 3 trial on TPT, we described our experience with the use of rifampicin for 4 months (4R) and isoniazid for 9 months (9H) in Indones…
Rangaka MX, Hamada Y, Duong T, Bern H, Calvert J, et al.
…ises its therapeutic effectiveness. Novel rifapentine-based regimens and treatment support based on behavioural science theory may improve treatment adherence and completion. Methods and analysis A pragmatic multicentre, open-label, randomised controlled trial assessing the effec…
Meenu Singh, Kulbir Kaur, Anil Chauhan, Manvi Singh, HarnoorKaur Sra, et al.
…e efficacy and safety of isoniazid (INH) versus alternative regimens for preventing active tuberculosis in children. Methods: A detailed analysis of the randomized controlled trials, methodology, interventions, and outcomes was done. Electronic searching was done through differen…
Macaraig MM, Jalees M, Lam C, Burzynski J
…ectiveness of preferentially offering two shorter treatment regimens-4 months of daily rifampin (4R) and 3 months of once-weekly isoniazid and rifapentine (3HP)-as an alternative to 9 months of daily isoniazid (9H) for the treatment of latent tuberculous infection (LTBI). Design …
Huashan Hospital
… been established. The integration of ultra-short treatment regimens with active screening holds the potential to provide a comprehensive and effective strategy for tuberculosis prevention and control in school environments, which may help reform the national tuberculosis policy …
Jann‐Yuan Wang, Hung‐Ling Huang, Chih‐Hsin Lee
<bold>Background:</bold> The 3HP regimen—weekly rifapentine plus isoniazid for 12 doses—improves the completion rate of latent tuberculosis infection (LTBI) treatment, but flu-like symptoms are common. The new 1HP regimen—daily rifapentine plus isoniazid for 28 days—has low toxic…
Santin M, Perez-Recio S, Grijota MD, Anibarro L, Barcala JM, et al.
…the study is to evaluate three short-course rifamycin-based regimens for the treatment of latent TB in ESKD patients. Methods Study design and setting. This is a prospective, open label, randomized clinical trial, that will be conducted at seven teaching hospitals in Spain. Study…
World Health Organization
… support the generation of high-quality evidence on new TPT regimens, addressing persistent limitations in available data, including low certainty of evidence, incomplete reporting and insufficient consideration of key decision-making criteria. Developed as a complement to WHO t…
Paola Castellotti, Maurizio Ferrarese, Matteo Saporiti, Daniela Campisi, Giorgio Besozzi, et al.
…in contacts of INH-resistant cases, while RIF containing PT regimens progressively became a prevalent choice from 2011 on. Of the 18961 with complete records, 82,7% received isoniazid (INH) for 6 months, 15.4% combined rifampicin and isoniazid ( RIF+INH) for 3 months, and 1.9% RI…
Ortiz Laza N, Lopez Aranaga I, Toral Andres J, Toja Uriarte B, Santos Zorrozua B, et al.
…ronic record. Three World Health Organization-approved LTBI regimens have been used: isoniazid for 6 months (6H), rifampicin for 4 months (4R), and isoniazid and rifampicin for 3 months (3HR). Centralized follow-up by a TB nurse case manager started in January 2016, with regular …
Winters N, Belknap R, Benedetti A, Borisov A, Campbell JR, et al.
…recommended for tuberculosis preventive treatment. As these regimens have not been compared directly, we used individual patient data and network meta-analysis methods to compare completion, safety, and efficacy between 3HP and 4R. Methods We conducted a network meta-analysis of …
Alvarez GG, Sullivan K, Pease C, Van Dyk D, Mallick R, et al.
… 2016, 3HP was offered as an alternative to standard clinic regimens which included 9 months of daily isoniazid or 4 months of daily rifampin. The primary outcome was the proportion of patients who completed TPT among all patients who started treatment. Using segmented autoregres…
Miguel Santín
…h rifapentine (P) + isoniazid (H) weekly for 12 weeks (3HP) regimens is better than with a 3-month (3HR) regimen for treatment of latent tuberculosis (TB) infection (LTBI) in patients with end stage kidney disease. Methods Design: Multicenter, prospective, parallel-group, open-l…
Qingfeng Sun, Kai Zhang, Jifei Chen, Lizhen Feng, Liuchun Shi, et al.
**BACKGROUND:** Tuberculosis preventive treatment (TPT) is essential for reducing the progression of latent tuberculosis infection (LTBI) to active disease, yet real-world implementation often faces substantial attrition. This study evaluated the acceptance, completion, and safet…
Yoo H, Chun Ji S, Cho JY, Kim SH, Yoon JG, et al.
Isoniazid is a therapeutic agent for the treatment of latent tuberculosis infection. Genetic variants in the N-acetyltransferase 2 (NAT2) are associated with the safety and pharmacokinetics of isoniazid. The study aimed to evaluate the safety and pharmacokinetics of a NAT2 genoty…
Simkins J, Donato-Santana C, Morris MI, Abbo LM, Camargo JF, et al.
…T-GIT-positive and QFT-GIT-negative donors. We assessed the regimens used to treat LTBI and whether the recipients of QFT-GIT-positive donors developed active tuberculosis (TB). Results Forty out of 427 (9%) potential living kidney donors had a positive QFT-GIT. QFT-GIT-positive …
Xin H, Cao X, Zhang H, Feng B, Du Y, et al.
Background Enlarging tuberculosis (TB) preventive treatment among at-risk populations is a critical component of the End TB Strategy. There is an urgent need to develop suitable latent tuberculosis infection (LTBI) testing and treatment tools according to the local TB epidemic an…
Christopher Pease
Background: The incidence of tuberculosis (TB) among Inuit is over 400 times that of Canadian-born non-indigenous people. To address this, more patients will need to complete preventative treatment. Methods: First, data were extracted retrospectively for all patients with a tuber…