Results for "regimens"200

In TB, an 8-wk, 5-drug regimen was noninferior to a standard 24-wk, 4-drug regimen for clinical outcomes at 96 wk

Sacks HS

Source citation Paton NI, Cousins C, Suresh C, et al; TRUNCATE-TB Trial Team. Treatment strategy for rifampin-susceptible tuberculosis. N Engl J Med. 2023;388:873-887. 36808186.

Target regimen profiles for TB treatment: candidates: rifampicin-susceptible, rifampicinresistant and pan-TB treatment regimens

World Health Organization

Can DR-TB Regimens be Sometimes Given to Select Drug Sensitive Cases?- A Clinician’s Perspective

Tushar R. Sahasrabudhe

… Revised National TB Control Programme (RNTCP) as DOTS plus regimens. These regimens involved use of less potent second-line drugs which were at least 5 and up to 7 in number based on grouping of medicines, and were required to be taken for a longer duration, often ranging from 1…

WHO consolidated guidelines on tuberculosis 2020 moving toward fully oral regimen

Nirmal Kumar Jain

…ed guidelines published in March 2020 recommends fully oral regimens for drug-resistant tuberculosis (DR-TB) that is isoniazid-resistant TB, rifampicin-resistant TB (RR-TB), multi-DR-TB (MDR-TB), and extensively DR-TB (XDR-TB). These regimens are said to be game changer for these…

Shorter and Safer Treatment Regimens for Latent TB

Dick Menzies, MD

…fe; 2. Tuberculosis Preventive Treatment (TPT) with shorter regimens are superior with respect to acceptance, completion, and costs; 3. 4 months of Rifampin 10mg/kg (4R10) is the safest regimen, but is completed by \<80% of patients; 4. The safety of 2 months of Rifampin 20mg/kg …

A Leap Forward – All Oral Regimens Revolutionizing Multidrug-resistant Tuberculosis Treatment

Durga Balagopalan

All oral regimens have become a great advancement in the treatment of multidrug-resistant tuberculosis (MDR-TB). Earlier, the treatment of MDR-TB was considered long, with side effects and more relapse rate. The best estimate of the proportion of people diagnosed with MDR/Rifampi…

Towards Shorter, Child-Friendly Regimens for Treatment of Tuberculosis Disease and Infection in Children

Courtney M. Yuen, Moorine Sekadde, Brian Kaiser, Brenda Waning, Stephen M. Graham

…for TB disease or infection, the length of common treatment regimens poses a challenge to the implementation of child-friendly TB care. Undergoing TB disease treatment, which previously ranged from 6 months for drug-sensitive TB to up to 2 years for multidrug-resistant TB (MDR-TB…

Novel Thrice-Weekly Isoniazid plus Rifapentine Short-Course Regimen for the Treatment of Latent Tuberculosis Infection in a Murine Model

Qiaoling Ruan, Jingyu Zhou, Shufeng Weng, Lingyun Shao, Wenhong Zhang

…ts. The World Health Organization recommends LTBI treatment regimens, including 6 or 9 months of once-daily isoniazid (INH, H), 4 months of once-daily rifampin (RIF, R), 3 months of once-weekly rifapentine (RPT, P) plus INH (3HP), 3 months of once-daily RIF plus INH, or 1 month o…

The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB

Sarah Meredith, MD, Andrew Nunn, PhD

… the rise, there is a need to investigate optimal treatment regimens using effective drugs. The STREAM study is an international, multi-centre, parallel-group, open-label, randomised, controlled trial in patients with multi-drug resistant tuberculosis (MDR-TB) including patients…

Pilot Clinical Trial of PRS TB Regimen I - Phase II

sha wei

…osis infection, we identified several new experimental drug regimens among billions of possible drug-dose combinations that outperform the current Standard Regimen. We used the PRS platform to optimize the in vivo drug doses of novel regimens (designated PRS regimen) in a mouse m…

TBTC Study 31: Rifapentine-containing Tuberculosis Treatment Shortening Regimens

Susan Dorman, MD, Payam Nahid, MD, MPH, Susan Swindells, MBBS, Richard Chaisson, MD, Ekaterina V Kurbatova, MD, PhD, MPH

…of this study is to determine whether one or two four-month regimens of tuberculosis treatment are as effective as a standard six-month regimen for treatment of pulmonary tuberculosis (TB). All three regimens are administered daily, seven days each week, with direct observation o…

Economic evaluation of shortened, bedaquiline-containing treatment regimens for rifampicin-resistant tuberculosis (STREAM stage 2): a within-trial analysis of a randomised controlled trial

Rosu L, Madan JJ, Tomeny EM, Muniyandi M, Nidoi J, et al.

…he STREAM stage 2 trial assessed two bedaquiline-containing regimens for rifampicin-resistant tuberculosis: a 9-month all-oral regimen and a 6-month regimen containing an injectable drug for the first 2 months. We did a within-trial economic evaluation of these regimens. Methods …

Economic Evaluation of New MDR TB Regimens

Sedona Sweeny

…iming to assess the costs to patients and providers of such regimens and to estimate the cost-effectiveness and poverty impact of an introduction of new MDR-TB regimens in the three countries participating in the main study. Multidrug resistant tuberculosis (MDR TB), tuberculosi…

BPaL/BpaLM regimen: A bright future for drug–resistant tuberculosis

Oki Nugraha Putra, Telly Purnamasari

…t tuberculosis (XDR-TB) and MDR-TB[3]. It demonstrates that regimens containing pretomanid and BPaL or BPaLM were associated with favorable outcomes (cured). BPaLM consists of bedaquiline (400 mg once daily for the initial two weeks, followed by 200 mg thrice weekly for 22 weeks)…

NGS-Guided(G) Regimens(R) of Anti-tuberculosis(A) Drugs for the Control(C) and Eradication(E) of MDR-TB

Wenhong Zhang, PhD,MD

…or MDR-TB treatment success rates suggest that current drug regimens are suboptimal. In addition, they are costly with a high pill burden, as many drugs, with significant potential for adverse events, are given for a long duration. These factors also inhibit good treatment compli…

Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs

Clemens DL, Lee BY, Silva A, Dillon BJ, Masleša-Galić S, et al.

…ile many TB drugs are available, identification of the best regimens is challenging because of the large number of possible drug-dose combinations. We have found consistently that responses of cells or whole animals to drug-dose stimulations fit a parabolic response surface (PRS)…

Short-course Regimens for the Treatment of Pulmonary Tuberculosis

Kelly Dooley, MD, Daniel W Fitzgerald, MD, Ekaterina V Kurbatova, MD, PhD, MPH, Wendy Carr, PhD

…se of this study is to determine whether one or two 17-week regimens of tuberculosis treatment bedaquiline (B or BDQ), moxifloxacin (M), pyrazinamide (Z)-- (BMZ) plus either Rifabutin (Rb) or Delamanid (D or DLM) are as effective as a standard six-month regimen for treatment of p…

Long-term efficacy and safety of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): extended follow-up of an open-label, multicentre, randomised, non-inferiority trial

Goodall RL, Nunn AJ, Meredith SK, Bayissa A, Bhatnagar AK, et al.

…round STREAM stage 2 showed that two bedaquiline-containing regimens (a 9-month all-oral regimen and a 6-month regimen with 8 weeks of aminoglycoside) had superior efficacy to a 9-month injectable-containing regimen for rifampicin-resistant tuberculosis up to 76 weeks after rando…

Drug-resistant tuberculosis: Progress towards shorter and safer regimens

Kavitha Saravu, Madhukar Pai

…drugs (e.g. bedaquiline) as well as shorter, individualized regimens, based on DST results.[2] In a study published in this issue of Lung India, Singh et al. reported on the treatment outcomes of a modified DOTS-plus strategy among 98 consecutive culture-proven adult MDR-TB patie…

Risk of SDRs Under 3HP and 1HP Regimen for LTBI

Jann-Yuan Wang, MD, PhD

…1.00-1.02\], p = 0.218). The 3HP regimen is among the four regimens for LTBI that is recommended by the WHO and is also probably the most promising regimen because of its convenience, with only 12 doses requried. With its effectiveness well established, the major remaining conce…

Are pretomanid-containing regimens for tuberculosis a victory or a victory narrative?

Lindsay McKenna, Jennifer Furin

… needed on the safety and efficacy of pretomanid-containing regimens, and such data can be found in the paper published in The Lancet Respiratory Medicine by Conor Tweed and colleagues.6Tweed CD Dawson R Burger DA et al.Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide duri…

Sitafloxacin-containing Regimens for Shortening Tuberculosis Treatment

First Affiliated Hospital of Zhejiang University

…o determine whether the sitafloxacin-containing three-month regimens are as effective as the standard six-month regimen and the four-month rifapentine and moxifloxacin regimen (substitution of rifapentine for rifampin and moxifloxacin for ethambutol) for treatment of pulmonary tu…