Showing 1–25 of 200 documents
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Ganes Mahata, Rupam Kumar T. A, Pronoy Sen, Sandip Mukhopadhyay
The emergence of drug resistant mycobacterium has become a significant public health problem creating an obstacle to effective tuberculosis (TB) control. Freedom from TB is possible with timely, regular, complete treatment, with assurance, prevention and management of side effect…
Г. Н. Можокина, A. G. Samoylov, I. А. Vаsilyevа
…and the prospects of their use in the treatment of multiple drug resistant and extensively drug resistant tuberculosis. The article describes mechanisms of action of beta-lactams and macrolides on tuberculous mycobacteria; the results of studies and safety profiles are given.
Salman Khan, Nadeem ur Rehman, Mohammad Zubair, Nisar Khan
Abstract Background: Multidrug-resistant tuberculosis (MDRTB) is a growing global health concern that is a chronic danger to world health due to tuberculosis (TB). Objective: The aim of this study was to examine the frequency of both pre extensively drug-resistant tuberculosis (P…
Gudisa Bereda
…levating number of second-line medicines used to treat multidrug-resistant tuberculosis are becoming a threat to public health worldwide. Recent guidelines recommended at least 20 months of treatment, but recent regimens are toxic, poorly tolerated and insufficiently effective, w…
Hanif Esmail, Gopalan Narendran, Andrew Nunn
The management of drug-resistant tuberculosis (DR-TB) has been a formidable challenge for patients, healthcare providers and public health systems for many years. In particular, for multidrug-resistant TB (MDR-TB), resistant to both rifampicin and isoniazid, the available treatme…
Itu Singh, Utpal Sengupta
… continued till the appearance of primary and secondary DDS resistance during the 1970s.[45] Most of these DDS-resistant cases originated from fully treated relapse cases. However, it was noted that low doses of dapsone and irregular treatment were the major causes of relapse.[5]…
Parissa Farnia, Poopak Farnia, Jalaledin Ghanavi, Saeid Besharati, Ali Akbar Velayati
…ion, insertion, or substation occurred in susceptible, mono-drug and multidrug resistant-TB isolates were observed at PE-PGRS family protein Wag22 (Rv1759c) and PE_PGRS31 (Rv1768) at exponential phase. Although, a large deletion (at Rv1759c; Rv1768) was observed in extensively dr…
Cicilia Windiyaningsih, Hendra Badaruddin
…sistant tuberculosis is a global challenge especially multi-drug resistant TB (MDR-TB). Drug-resistant Tuberculosis is classified as a condition where Mycobacterium tuberculosis can’t be treated with anti-tuberculosis drugs. The study aimed to determine the associated risk factor…
Shirin Tarafder, Bayzid Bin Monir
…a and to determine any relationship of these genotypes with drug resistance the most essential method is molecular typing. It allows a rapid and precise species differentiation. Objective: This study was intended to observe the genotypes of XDR mycobacterium tuberculosis by deter…
Vinay Jasani, Ahmed Abdelaal, Mohamed Mohamed
…eption of the first antituberculous chemotherapeutic agent, drug resistance has been one of the most challenging problems facing the global fight to control tuberculosis. Drug resistance to antituberculous chemotherapy is a spectrum which includes mono-drug resistance (e.g. rifam…
Neetha S. Murthy, Sanjeev Nair, P. Ramya, Renu Susan George, B Ravikrishnan, et al.
Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine the genotypic drug resista…
Rahul Kumar, Rajiv Garg, Silpa Kshetrimayum, Amita Jain
Background: Drug Resistant Tuberculosis (DR-TB) is a major threat to the realization of the goal of a TB free world in the near future. It is important to study the reasons for the increasing number of such cases so that effective action can be taken to control this growing epide…
Yousaf Jamal, Jamal Ahmad, Afsar Ali, Mahmood Iqbal Malik, Sultan Mehmood Kamran, et al.
Objective: To study the patterns of resistance to anti tuberculosis drugs in patients of drug resistant pulmonary tuberculosis. Study Design: Cross sectional analytical study. Place and Duration of Study: Department of Pulmonology, PEMH Rawalpindi from Jul 2016 to Dec 2017. Metho…
Beijing Hospital
Background: Drug resistant tuberculosis is a serious public health problem that threatens the health of human life and the development of society and economy. At present, the diagnosis of drug-resistant tuberculosis mainly depends on traditional drug susceptibility test. But it …
Kübra Yıldırım, Cemilenur Ataş, Ece Şimşek, Ahmet Yılmaz Çoban
…evaluate the AYC-SENSITIVE® kit for rapid detection of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) isolates. With the AYC-SENSITIVE® kit, a total of 36 isolates for susceptibility testing were evaluated (5 of which are standard (…
Microbiologist- External Quality Assurance, State TB control Society, Port Blair, Andaman and Nicobar Islands, Keerthivasan Gurumurthy
… concern in India especially with the increasing numbers of drug-resistant cases of tuberculosis. Lack of early diagnosis, inadequate and inappropriate treatment are the major contributors to the development of drug resistance. PMDT strategy strives for early diagnosis and approp…
Bashir Ullah, Rukhsana Saboor, Muhammad Zahid Iqbal, Atiq Ahmad Bhatti, Abad Ur Rehman, et al.
Aim: To determine the frequency of pre-extensively drug resistant tuberculosis, extensively drug resistant tuberculosis in patients with multi-drug resistant tuberculosis. Study design: Retrospective/observational Place and duration of study: Department of Medicine, Bolan Medical…
Sadhana Awasthi, Neha Verma, Ram Gopal Nautiyal, Hariom Kumar Solanki
Background: Drug Resistant Tuberculosis (DR-TB) has frequently been encountered in India, and its presence has been known virtually from the time anti-TB drugs were introduced for the treatment of Tuberculosis. Multi Drug Resistant Tuberculosis (MDR-TB) is a man-made phenomenon a…
Wencong He, Yun‐Hong Tan, Peiying Li, Jingjing Bao, Yimeng Song, et al.
ObjectiveTo analyze the dynamic trend of drug resistance of Mycobacterium tuberculosis in Leiyang city, Hunan province from 2013 to 2017, and to understand the local drug resistance spectrum of M. tuberculosis, so as to provide evidences for the formulation of chemotherapy regime…
…le and author information Metrics Abstract The emergence of drug resistance in Mycobacterium tuberculosis (Mtb) is alarming and demands in-depth knowledge for timely diagnosis. We performed genome-wide association analysis using 2237 clinical strains of Mtb to identify novel gene…
Pradeep M Muragundi
Introduction: Extensively Drug-Resistant Tuberculosis (XDR-TB) is a recent challenge for tuberculosis control program. The absence of the functional drugs and high rate of the failure in treatment and mortality rate also high jeopardize for epidemiology. Its prevalence is unknown…
Rupam Kumar Ta, Pronoy Sen
BACKGROUND: The emergence of drug resistant mycobacterium has become a signicant public health problem creating an obstacle to effective Tuberculosis (TB) control. Freedom from TB is possible with timely, regular, complete treatment, with assurance, prevention and management of …
Hiral Gadhavi, Akansha Goyal, Binita Aring, Summaiya Mullan
The rate of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has been steadily increasing in developing countries like India. The availability of rapid and reliable methods for the detection of drug resistance to second-line drugs is vital for adeq…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
The emergence of drug-resistant tuberculosis jeopardizes the TB control programme activities globally. Multidrug-resistant TB is defined as tuberculosis strains resistant to at least two first-line drugs, rifampicin (RIF) and isoniazid (INH). Extensively drug-resistant TB refers …
Satyendra N. Shukla, Nitin Bhardwaj, Ashutosh Singh
…has emerged as a health risk due to its ability to adapt to drugs . The emergence of drug-resistant Mtb is affected by factors such as drug-resistant gene mutations, the efficacy of TB treatment, genetic background of the strain, and its ability to adapt to host and specific envi…