Showing 1–25 of 200 documents
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Vinay Jasani, Ahmed Abdelaal, Mohamed Mohamed
…eption of the first antituberculous chemotherapeutic agent, drug resistance has been one of the most challenging problems facing the global fight to control tuberculosis. Drug resistance to antituberculous chemotherapy is a spectrum which includes mono-drug resistance (e.g. rifam…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
The emergence of drug-resistant tuberculosis jeopardizes the TB control programme activities globally. Multidrug-resistant TB is defined as tuberculosis strains resistant to at least two first-line drugs, rifampicin (RIF) and isoniazid (INH). Extensively drug-resistant TB refers …
Rajeev Ranjan, Venkata Siva Reddy Devireddy
Drug resistant tuberculosis is a major public health concern, since the causative agent Mycobacterium tuberculosis is resistant to the most effective drugs against tuberculosis treatment ie., rifampicin and isoniazid. Globally, it accounts 4.6 percent of the patients with tubercu…
Apoorva Narain, Surya Kant, Rikesh K. Dubey, Kanchan Srivastava, Anand Kumar Maurya
…onential increase in tuberculosis (TB) cases, mainly by the drug-resistant (DR) strains of MTB, has created an urgent need for identifying and developing new antituberculosis drugs acting via novel mechanisms. The multi drug-resistant (MDR) TB and extensively drug-resistant (XDR)…
Sunil Bajeja, Kandula Jayapaul, Poonam Gaur, Chinnem Rama Mohan, Abhinav Pathak, et al.
… problem around the world. This is especially true now that drug-resistant forms of TB like Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) are becoming more common. Traditional ways of diagnosing drug resistance take a lot of time and resources, which means they …
Parikshana Mathur, Pinky Choudhary, Rajkuberan Chandrasekaran, Ragini Singh, Hemant Kumar Daima
…nt even after the global initiatives and emergence of multi-drug resistance (MDR) strains have made the situation complicated. Herein, the exploitation of the same medications for several decades, ineffective drug administration, and insufficient patient follow-up are some of the…
Kara Lukas, Madeleine T Dang, Clare Necas, Vishwanath Venketaraman
…uberculosis (TB) is a global health challenge caused bywith drug resistance, treatment toxicity, and treatment adherence challenges continuing to impede control efforts. The objective of this review is to explore current advancements in TB treatment, for both drug-sensitive and d…
Mani Sharma, Sakshi Kansal
…are numerous factors responsible for the emergence of multi-drug resistance and extensively drug resistance cases of tuberculosis, which involves high pill burden, prolonged treatment, low compliance, and stiff administration schedules. Continuous efforts have been done to develo…
Usharani Brammachary, Venkateswari Ramachandra, Suganthi Palavesam, Vidya Raj Cuppusamy Kapalamurthy, Aaina Muralidhar, et al.
…ry TB regimens consist of 6–9 months of daily doses of four drugs in the existing regimen that is extremely toxic to patients. The purpose of these longer treatments is to eliminate Mycobacterium tuberculosis, notorious for its ability to resist most antimycobacterial drugs, ther…
Tanzila K. Chowdhury, Laurence A. F. Park, Glenn Stone, Mark M. Tanaka, Andrew Francis
…lly and is exacerbated by a growing problem with antibiotic drug resistance. To control the spread of such resistance, it is important for public health authorities to know whether drug-resistant strains in their population have arisen from the ineffective treatment of a previous…
Prashant Wakhare, Shagufta Md S Sheikh, Pragati Mahale, Pritesh Patil, Sanjay Bhilegaonkar, et al.
…mmon infectious disease that kills people around the world. Drug-resistant types like multi-drug resistant (MDR-TB) and widely drug-resistant TB (XDR-TB) are becoming more common, which makes treatment much harder. Molecular tests and trait drug resistance testing are common ways…
Anita Saibannavar, Gurjeet Kaur, Nitin Kumbhar
**INTRODUCTION:** Drug resistant Tuberculosis (DR-TB) continues to be a major concern for public health, particularly in countries like India with high disease burden. Recognizing resistance trends and appropriate therapeutic approach is critical for improving patient outcomes an…
Lynn Sosa, Lloyd N. Friedman
…l location of the treatment facility. The usual therapy for drug-sensitive tuberculosis (TB) comprises four drugs for 2 months, dropping ethambutol once the organism is known to be sensitive to isoniazid, rifampin, and pyrazinamide; then continuing maintenance isoniazid and rifam…
Rafael Laniado-Laborı́n
The presence of drug resistance should always be suspected when there are risk factors for it and must be confirmed by bacteriological or molecular tests for standardized drug sensitivity. Any regimen for drug-resistant TB is more likely to be effective if its composition is base…
Erfaneh Jafari, Reza Azizian, Mohsen Tabasi, Morteza Banakar, Kamran Bagheri Lankarani
… by, remains a major global health burden. The emergence of drug-resistant strains presents a critical challenge in TB management. The recent research has explored the interaction between TB and the human gut bacteriophage community (phageome). The gut phageome plays a crucial ro…
Piyushkumar Sadhu, Mamta Kumari, Niyati Shah, Chitrali Talele, Nirmal Shah, et al.
Drug-resistant tuberculosis, particularly those with rifampicin resistance (RR-TB), has emerged as one of the major challenges to the goal of eliminating tuberculosis. Additionally, three or four different medications must be used in an effort to treat TB, but sadly, there aren't…
Shuying Zhang, Juan Cheng, Yuanyuan Tang
Drug-resistant(Mtb) has become a global public health crisis, and its diverse drug resistance jointly reduces the effectiveness of antibacterial drugs. Mtb resistance is not merely genetic but involves a synergistic interplay of cell wall remodeling, metabolic reprogramming, and …
Mehdi Roshdi Maleki
…h due to infectious disease. Additionally, the emergence of drug-resistant strains has created a significant challenge for the treatment of this disease. Approximately 25% of TB-related deaths are attributed to antimicrobial drug resistance. Various mechanisms contribute to the d…
Maciej Michalik, Tomasz Lorenc, Krzysztof Marcinkowski, Mateusz Muras, Natalia Mikszta, et al.
Drug-resistant tuberculosis (DR-TB) poses a significant global health threat, particularly in low- and middle-income countries with limited access to quality healthcare. By 2023, 10% of global tuberculosis cases were classified as drug-resistant, with multidrug-resistant (MDR-TB)…
Drug-resistant tuberculosis is a re-emerging public health concern which requires special attention all around the world.Among all the infectious diseases, drug-resistant tuberculosis is now the most lethal infection causing disease in both children and adults.The co-infection of…
John W Wilson, Zelalem Temesgen, James T Gaensbauer
…of management updates recently have been published for both drug-susceptible and drug-resistant tuberculosis (TB), TB in children, and contacts of patients with drug-resistant TB. The operationalization and application of these recommendations, which reflect favorable clinical tr…
Carolina H Chung, Rupa Bhowmick, Annie J Badenoch, Harkirat S Arora, Sriram Chandrasekaran
Drug resistance is a major challenge in cancer and infectious diseases, requiring innovative solutions. Recent research suggests that bacteria and cancer cells reprogram their metabolism and manipulate their external metabolic environment to resist a diverse range of therapeutics…
Chiara Sepulcri, Francesca Saluzzo, Daniele Roberto Giacobbe, Antonio Di Biagio, Daniela Maria Cirillo, et al.
**INTRODUCTION:** Drug-resistant tuberculosis (DR-TB) still represents a critical global health threat despite recent therapeutic advances. The shift from long, injectable-based regimens to shorter, all-oral regimens has improved outcomes, yet substantial challenges remain in ens…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
Drug resistance in Mycobacterium tuberculosis (Mtb) is a complex phenomenon resulting from multiple coordinated molecular and genetic mechanisms that allow the bacterium to evade antimicrobial agents. Intrinsic resistance primarily stems from the unique architecture of the mycoba…
Roopendra Kumar, Jagdeep Singh Sohal, Ajay Vir Singh, Devendra Singh Chauhan
…Pretomanid, and Linezolid) regimen for treating extensively drug-resistant (XDR) and treatment-intolerant/ nonresponsive multidrug-resistant (MDR) cases of pulmonary tuberculosis (TB). It offers new hope in the global fight against drug-resistant TB, which remains a major health …