Showing 101–125 of 200 documents
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Federico Appetecchia, Mariangela Biava, Giovanna Poce
… shortcomings such as length, dosage regimen, toxicity, and resistance development to currently used medicines. The emergence of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis is a major concern in controlling the disease. Therefore, there is an urge…
Rima Zein-Eddine, Masoud Ramuz, Guislaine Refrégier, Johannes F Lutzeyer, Alexey Aleksandrov, et al.
… has a high mortality rate, particularly without treatment. Drug resistance is rising, with treatments against multidrug-resistant TB (MDR-TB) showing poor treatment success rates. The thick, lipid-rich wall of Mtb and its slow growth reduce antibiotic effectiveness, requiring lo…
Xiaoying Jin, Jiajun Wang, Yongdui Ruan, Jiaxiang Li, Xinen Kong, et al.
…n shown to eliminate bacterial biofilms, thereby increasing drug sensitivity of drug-resistant bacteria. Therefore, combining NO with antibiotics may be a strategy for treating drug-resistant tuberculosis (DR-TB). However, owing to the limitations of NO, including their short hal…
Sandip Patil, Indu Singh, Indira Kumari Verma, Anil Kumar, Juhi Sharma, et al.
Antimicrobial resistance (AMR) poses a formidable global threat, undermining the efficacy of potent antibiotics and complicating the treatment of infectious diseases, which has attracted the attention of scientific communities to revisit vaccines as a potential candidate against …
Andy Setiawan, Pramudya Pramudya, Hasyrin Ainun
Multidrug-resistant tuberculosis (MDR-TB) represents a strain of TB bacteria that exhibits resistance to a minimum of two primary anti-TB medications: Isoniazid and Rifampicin, both of which are regarded as the most potent drugs for combating TB.The management of drug-resistant T…
Venus Marie R Rojas, Michaela Zwyer, Selim Bouaouina, Daniela Brites, Sonia Borrell, et al.
…ly widespread and have been repeatedly associated with multidrug resistance. By comparison, MTBC L1 has received little attention, partially because of its restricted geographical range that mainly includes low- to middle-income countries in South and Southeast Asia, and East Afr…
Luana Layse Câmara de Almeida, Sayoane Pessoa Fernandes, Genil Dantas de Oliveira, Marcelly da Silveira Silva, Thalisson Amorim de Souza, et al.
…of deaths worldwide. Despite some research progress for new drug candidates, drug repurposing, and new regimens, there is still an urgent need for the new medicins to treat TB, especially due to the growing cases of multidrug and extensively drug-resistant (MDR/XDR) strains. Drug…
Hemali Savla, Bhushan S. Bhale, Nisha Sharma, Pradnya R. Petkar
…fecting millions of people worldwide. The emergence of multidrug-resistant (MDR) and extremely drug-resistant (XDR) strains of Mtb has further increased the disease-related mortality and morbidity in developing countries due to the poor efficacy of currently existing therapeutic …
Sarita Rani, Ankur Kaul, Anil Kumar Mishra, Umesh Gupta
…thogenesis, types, diagnosis tests, emergence of MDR (multi drug resistance) and XDR (extensively drug resistance). The traditional chemotherapy of TB includes first and second line drug therapy. These lines of therapies face many difficulties such as low solubility, low bioavail…
Ye Myat, Chris Orton, Hannah Jarvis, Onn Min Kon
…improve diagnostic accuracy and ability to quickly identify resistance patterns. Standard treatment choices and route of administration may need to be modified given uncertain enteral absorption and concerns over drug interactions and drug resistance. Infection control measures c…
Onix Cantres-Fonseca, Francisco Del Olmo-Arroyo
…ce rest in worldwide prevalence, pathogen spread, treatment resistance and the need for eradication. Drug treatment resistance is considered as one of the criteria to prioritize a country in the World Health Organization’s intention to eradicate tuberculosis infection in the worl…
Amira Mahmood, Mohammad Bilal Ashfaq, Catherine Drain, Eoin Melby, Michael Hunter, et al.
…th an estimated 1.25 million deaths per year. The quadruple drug regimen of rifampicin, isoniazid, pyrazinamide, and ethambutol has been standard therapy for 40 years, with good outcomes in patients with drug susceptible tuberculosis who are able to tolerate the drug regimen. How…
Siqi Lin, Qianqian Zhang, Juan Liu, Bojie Lin, Daina Zhao, et al.
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), coupled with lengthy treatment cycles and adverse side effects of traditional therapies, poses a significant global challenge in the form of tuberculosis (TB). Photodynamic therapy (PDT) generates reacti…
C. M. Divyashanthi, S. Kumar, N. P. Bharathi
Background: Antimicrobial drugs includes all agents that work against a variety of microorganisms such as bacteria, viruses, fungi and parasites. Antimicrobial resistance is when bacteria or other microbes become resistant to the effects of a drug after being exposed to them. Bac…
Luis M Rodríguez-Martínez, Jose L Chavelas-Reyes, Carlo F Medina-Ramírez, Eli Fuentes-Chávez, Zurisaday S Muñoz-Troncoso, et al.
…e than 20,000 new cases annually and a rising proportion of drug-resistant strains. This work addresses the molecular epidemiology of TB in the Mexican context, emphasizing its role in understanding transmission, genetic diversity, and resistance mechanisms. To achieve this, we r…
Jingxian Ning, Rong Wang, Yuchen Pan, Xinru Fei, Wenxin Jiang, et al.
…ies reporting median survival time or YPLL in patients with drug-susceptible or drug-resistant tuberculosis were included, mostly involving adult participants. Two reviewers independently screened studies and extracted data. Any disagreements were resolved by consensus or by arbi…
Suma Sarojini, Saranya Jayaram, Sandhya Kalathilparambil Santhosh, Pragyan Priyadarshini, Manikantan Pappuswamy, et al.
… scenario soon started becoming worse with the emergence of drug-resistant strains within years of the deployment of antibiotics in the market. With the surge in the misuse of antibiotics, there was a drastic increase in the number of multidrug-resistant (MDR) and extensively dru…
Patrick Howlett, Robert J. Wilkinson, Ben J. Marais
…ment, TB and HIV, TB in Children, Treatment regimens, Multi-drug resistant and extensively drug resistant TB , Lessons learned in TB treatment and control
Omid Nikjeh, Seyedehparmis Rejali, Kayvan Sasaninia, Vishwanath Venketaraman
For drug-susceptible TB, the WHO-endorsed first-line regimen (isoniazid, rifampicin, ethambutol, pyrazinamide) remains the global reference. Therapy must always be tailored to drug susceptibility, especially in MDR- and XDR-TB. HIV-associated mycobacterial infections-including(TB…
Andy Setiawan, Pramudya Pramudya, Hasyrin Ainun
Multidrug resistance tuberculosis (MDR-TB) is a form of tuberculosis bacterial resistance to at least two first-line anti-TB treatments, isoniazid and rifampicin, the two most effective TB medications.Treatment of Drug Resistant TB is set to be part of the national TB Control pro…
Amitesh Gupta, Eshutosh Chandra, Parul Mrigpuri
…c control. Meanwhile, challenges persist due to the risk of drug resistance, complications from multi-drug-resistant TB, and heightened mortality. In conclusion, TB-DM comorbidity calls for an integrated healthcare response, combining individualized treatment with strengthened he…
Bidyarani Devi Konjengbam, Heikrujam Nilkanta Meitei, Anupama Pandey, Reena Haobam
… be a major health problem globally. The emergence of multi-drug-resistant TB and extensively drug-resistant TB has become a severe threat to TB control programs. Currently, the Bacille Calmette-Guerin (BCG) vaccine protects a child from disease dissemination efficiently, but its…
Wei Zhang, Qing Wang, Liru Zhang, Jiangxiong Wu, Jinlu Liu, et al.
…lated Escherichia coli from 2014 to 2022. Methods: In vitro drug sensitivity of E. coli to 20 antibiotics was examined using the microbroth dilution method. A total of 7580 clinical E. coli strains were isolated from 2014 to 2022, among which 56.9% were identified as extended-spe…
Periyasamy Vijayalakshmi, Faiz Alfaiz, Rajendran Vijayakumar, Deepali Desai, Chandrabose Selvaraj
…s a major public health problem with increased incidence of drug-resistant TB due to failure of existing treatments. Current anti-TB drugs are mainly directed at targeting important biochemical pathways in the Mtb with the biotransformation of drugs through hepatic metabolism. Ho…
Thi Mai Nguyen, Emily Lai-Ho MacLean, Xiaomei Zhang, Sophia B Georghiou, Hui Xia, et al.
… is concerning, given its status as the most common form of drug-resistant tuberculosis and a gateway to multidrug-resistant diseases. Molecular drug-susceptibility testing has improved access to timely diagnosis of rifampicin-resistant tuberculosis, but testing for isoniazid-res…