Showing 1–25 of 72 documents
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Umulkhairah Onyioiza Arama, Oluwatoyin Ayo-Farai, Mosunmade Oshingbesan, Bushra Murtaza, Sana Rasheed, et al.
Human immunodeficiency virus (HIV) and tuberculosis (TB) co-infection in Nigeria are medical conditions of public health importance because they double the country's and its citizens' burden. Several management measures, including artificial intelligence (AI), are crucial for pro…
Catherine Keiko Gunawan, Anton Sumarpo, Agnes Rengga Indrati
…ysregulation is a hallmark of human immunodeficiency virus (HIV) infection, characterized by persistent immune activation and systemic inflammation that drive T cell exhaustion and senescence, contributing to disease progression and non-AIDS comorbidities, most notably tuberculos…
Bianca Sossen, Mmamapudi Kubjane, Graeme Meintjes
HIV-associated tuberculosis (HIV-TB) is associated with disproportionate mortality: approximately 24% of the 660,000 individuals with TB and HIV died, compared to 11% of those without HIV dying from TB in 2023. HIV is a key driver of ongoing high TB incidence in many countries, p…
Patrick K Moonan, Stephen O Mathew, Jerry W Simecka, Stephen E Weis
Early HIV infection disrupts TB-specific immunity, raising TB risk before CD4 decline. Early ART may help but cannot fully restore function, making tuberculosis preventive treatment indispensable-potentially lifelong-to close immunologic gaps and reduce HIV-associated TB morbidit…
Tayla Williamson, Jack Adderley, Kylie Quinn, Taane G Clark, Sharon R Lewin, et al.
… resistance in three globally relevant infectious diseases, HIV, tuberculosis (TB), and malaria. Specifically, we scrutinize the timelines between deployment and the subsequent emergence of resistance for all drugs that have been mobilized in the fight against these three disease…
Miriam Abadie, Alexander Kay
…ug-resistant tuberculosis (DR-TB) treatment for people with HIV (PWH), including drug-drug interactions, investigational medications and host-directed therapy, as well as emerging evidence on novel treatment regimens, post-TB complications, and DR-TB medication resistance among P…
Cender U Quispe-Juli, Jorge A Gallardo-Cartagena, Larissa Otero, Bruno B Andrade, Julio Croda, et al.
Tuberculosis (TB) and human immunodeficiency virus (HIV) cause significant morbidity and mortality in South America. Despite the advances in active case finding and early treatment initiation as core strategies to decrease TB and HIV transmissions, additional efforts are needed t…
María Belén Vecchione, Denise Anabella Giannone, Milagros Victoria Acevedo, Natalia Santucci, Maria Florencia Quiroga
…g cause of mortality worldwide among infectious agents, and HIV increases the risk of developing into active disease. HIV-TB coinfection impairs immune responses, while chronic inflammation and infection-associated stress activate neuroendocrine pathways that deeply impact immune…
Preena Prasanna, Bianca Herrera, Larry S Schlesinger, Mirko Paiardini, Riti Sharan
Tuberculosis (TB) and HIV coinfection present a significant global health challenge worldwide. While most individuals infected with Mycobacterium tuberculosis (Mtb) have clinically asymptomatic latent TB infection (LTBI), those with immunosuppressive conditions, such as HIV, are …
Christian Kraef, Ole Kirk
…an region of the WHO, the largest part of tuberculosis (TB)/HIV co-infection is found in parts of Eastern Europe. In other parts of Europe, TB among people with HIV has been declining with migrants at highest risk. This review provides an overview of the epidemiology, determinant…
Lingzi Luo, Reet Kapur, Mari Armstrong-Hough, Gloria Guevara Alvarez, Corrina Moucheraud, et al.
…CTION:** Integration of management of tuberculosis (TB) and HIV with prevention and treatment of non-communicable diseases (NCDs) is a global priority. However, delivering the full spectrum of HIV/TB and NCD services is hindered by a lack of evidence regarding effective models an…
Casimir Manzengo, Farai Mavhunga, Nlandu Roger Ngatu, Fleur Lignenguet, Stredice Manguinga, et al.
…lining, there have been challenges with treatment coverage, HIV status and treatment outcome documentation. Thus, the National TB Program (NTP) conducted an innovative data review at the Nkembo Health Treatment Center in Libreville, which manages more than 70% of Gabonese TB pati…
Christian Tague
HIV coinfection and multidrug-resistant tuberculosis (MDR-TB) pose a major public health challenge in sub-Saharan Africa, where high HIV prevalence promotes tuberculosis progression and complicates its management. In people living with HIV (PLHIV), profound immunosuppression lead…
Phoebe Gruccio, William S Girard, Amelia D Badipour, Reagan Kakande, Victor Adejayan, et al.
…s compounded by high rates of human immunodeficiency virus (HIV) and co-infections, including tuberculosis (TB), which is the leading cause of sepsis. Both HIV and TB can cause immune dysregulation and adrenal insufficiency, which may exacerbate CIRCI and prolong shock. Existing …
Omid Nikjeh, Seyedehparmis Rejali, Kayvan Sasaninia, Vishwanath Venketaraman
…ored to drug susceptibility, especially in MDR- and XDR-TB. HIV-associated mycobacterial infections-including(TB), disseminatedcomplex (MAC), and Mycobacterium()-remain leading causes of morbidity and mortality in people living with HIV (PLWH). TB continues to account for the hig…
Tim Crocker-Buque, Michael A Moso, Justin T Denholm, Kasha P Singh
**PURPOSE:** This update addresses HIV/TB co-infection management in pregnancy, focusing on new treatment options. **RECENT FINDINGS:** Pregnancy with HIV increases TB risk and worsens treatment outcomes. While long-acting antiretroviral therapies (LA-ART) like cabotegravir/rilp…
Spencer C Darveau, Sharan Yadav, Kelly E Dooley, Jyoti S Mathad
…ternal mortality globally, especially for women living with HIV. TB preventive therapy (TPT) regimens treat TB infection and prevent progression to TB disease, but the components of these regimens, including isoniazid and rifamycins, often interact with HIV antiretroviral therapy…
Siranjeevi Rangaraj, Anushka Agarwal, Sharmistha Banerjee
…on secondary infection in the Human Immunodeficiency Virus (HIV) infected population, accounting for more than one-fourth of deaths in people living with HIV (PLWH). Reciprocally, HIV infection increases the susceptibility to primary TB or reactivation of latent TB by several fol…
Pheletso Letuka, Michael Z Zulu
… infectious diseases, such as human immunodeficiency virus (HIV) and tuberculosis (TB). The pathogenesis of these conditions is associated with chronic, low-grade inflammation and immune activation that complicates various homeostatic functions, leading to increased risk of non-c…
Shixiong He, Changjiao Luan, Jiaqi Gao, Feng Lu, Fang Tian, et al.
…ed globally in 2023, of which 662,000 were co-infected with HIV, and the risk of death in patients with TB-HIV co-infections with HIV is three times higher than in patients with TB alone. Such co-infections significantly increase the complexity of the disease and the difficulty o…
Peter J Kitonsa, Devan Jaganath
…berculosis (TB), especially among children co-infected with HIV, remains a significant global health challenge. Traditional sputum-based diagnostics are less effective in this population due to difficulties in sample collection and paucibacillary disease, necessitating alternativ…
Kshitij Agarwal, Adam T Gray, Tudor P Toma, Valentina Luzzi, Lorenzo Corbetta
…ly in the context of multidrug-resistant TB (MDR-TB) and TB-HIV co-infection. Traditional surgical interventions, such as lung resection and pneumothorax induction, have largely been phased out with the advent of modern antibiotic regimens. However, emerging evidence suggests tha…
Andrew D Kerkhoff, Jason Zucker, Diane V Havlir
…erculosis and other opportunistic infections in people with HIV. High mortality rate among people with HIV hospitalized with disseminated tuberculosis (TB) and among those treated for drug-resistant TB represents a major clinical challenge. Intensified TB treatment in one trial a…
Salah Al Awaidy, Faryal Khamis, Sami Al Mujeini, Jameela Al Salman, Jaffar A Al-Tawfiq
…arying degrees of success in controlling drug-resistant TB. HIV-TB co-infection rates was highest in United Arab Emirates (5.4%) and Bahrain (5.1%), followed by Saudi Arabia (2.3%), Oman (1.4%), Qatar (0.6%), and Kuwait (0.5%). Notably, the GCC countries reported zero TB househol…
Pierre Goussard, Ernst Eber, Lisa Frigati, Leonore Greybe, Shyam Sunder B Venkatakrishna, et al.
…he burden of infectious diseases like tuberculosis (TB) and HIV, and the expertise and equipment available. TB diagnosis in children remains challenging due to the paucibacillary nature of the disease and its overlap with other infectious diseases like actinomycosis and echinococ…