Restoring TB-specific Immunity in Early HIV Infection-the Dual Promise of Early Antiretroviral and TB Preventive Treatment.
Patrick K Moonan, Stephen O Mathew, Jerry W Simecka, Stephen E Weis
The Journal of infectious diseases · 2026-05
Abstract
Early HIV infection disrupts TB-specific immunity, raising TB risk before CD4 decline. Early ART may help but cannot fully restore function, making tuberculosis preventive treatment indispensable-potentially lifelong-to close immunologic gaps and reduce HIV-associated TB morbidity and mortality.
MeSH terms
- Humans
- HIV Infections
- Tuberculosis
- Antitubercular Agents
- Anti-Retroviral Agents
- Anti-HIV Agents
- Coinfection