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Zhang SX, Wang JC, Yang J, Lv S, Duan L, et al.
…ackground The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge and is a major global public health issue. This study aims to elucidate the disease burden of HIV-TB co-infecti…
Shun-Xian Zhang, Jin-Xin Zheng, Yu Wang, Wen-Wen Lv, Jian Yang, et al.
…e years (DALYs) for TB from 1990 to 2021. Over this period, HIV-negative TB showed a marked decline in ASIR (AAPC = -2.34%, 95% CI: -2.39, -2.28) and ASMR (AAPC = -0.56%, 95% CI: -0.62, -0.59). Specifically, drug-susceptible TB (DS-TB) showed reductions in both ASIR and ASMR, whi…
Wang Y, Jing W, Liu J, Liu M
Background People living with human immunodeficiency virus (HIV) are more likely to develop tuberculosis (TB), and their co-infection (HIV-TB) increases the risk of death. We aimed to describe the global trends, regional differences and age distribution of HIV-TB. Methods Annual …
Margherita Bracchi, Clare van Halsema, Frank A. Post, Funmi Awosusi, Alison Barbour, et al.
…helped transform the management of TB in people living with HIV. The overall purpose of these guidelines is to help physicians manage adults with tuberculosis (TB)/human immunodeficiency virus (HIV) co-infection. Recommendations for the treatment of TB in HIV-positive adults are …
Zhang J, Kern-Allely S, Yu T, Price RK
…l to provide information for resource allocation to control HIV/AIDS, tuberculosis (TB), and their co-infection, especially in areas with high morbidity and mortality like East Asia and the Pacific. Therefore, we examined the morbidity and mortality of HIV/AIDS and TB co-infectio…
Dona Arlinda, Retna Mustika Indah, Aris Yulianto, Agus Dwi Harso, Armaji Kamaludi Syarief, et al.
…for tuberculosis (TB), multidrug-resistant (MDR) TB, and TB-HIV. We aimed to determine factors associated with poor TB treatment outcomes. A hospital-based TB Registry at seven referral hospitals in Java and Bali included data from patients aged ≥15 years who were diagnosed with …
Bhering M, Duarte R, Kritski A
…orldwide in the number of TB cases and 19 th in terms of TB-HIV co-infected cases. This study aims at identifying clinical and demographic factors associated with unsuccessful treatment outcomes (loss to follow-up, treatment failure and death) of HIV-positive patients with multid…
Annelies Van Rie, Sujit Suchindran, Emily Brouwer
…of human suffering and death. Human immunodeficiency virus (HIV), multi-drug resistant TB (MDR-TB), and extensive drug resistant tuberculosis (XDR-TB) have emerged as threats to TB control. The association between MDR-TB and HIV infection has not yet been fully investigated. We c…
Anna Panova, Vadim Testov, Grigory Kaminskiy, Anastasia Samoilova, E. I. Veselova, et al.
…e 2010. Nevertheless the burden of MDR-TB and co-infection (HIV-TB) remains. <b>Aims:</b> To study drug resistance among new TB cases in HIV-positive patients (Pts) in comparison with HIV-negative pts. <b>Methods:</b> Multicentral study was performed in 6 Russian regions with hig…
Wu Y, Zhang Y, Wang Y, Wei J, Wang W, et al.
…h drugs can achieve the greatest clinical benefit for DR-TB-HIV patients by comparing multiple chemotherapy regimens, to provide a basis for evidence-based practice. Methods We searched three electronic databases (PubMed, Web of Science and Cochrane) for related English studies p…
Tian X, Wang C, Hao Z, Chen J, Wu N
…ing trend in human immunodeficiency virus and tuberculosis (HIV-TB) in different regions from 1990 to 2021, and project future trends. Methods Global Burden of Disease Study 2021 data were analyzed to assess HIV-TB incidence, death, prevalence, and DALY rates from 1990 to 2021, i…
Ignatius EH, Swindells S
…tuberculosis (TB) incidence and mortality among people with HIV remain unacceptably high. Short-course regimens for TB, incorporating both novel and established drugs, offer the potential to enhance adherence and completion rates, thereby reducing the global TB burden. This revie…
Yuengling KA, Padayatchi N, Wolf A, Mathema B, Brown T, et al.
Background Extensively drug-resistant tuberculosis (XDR-TB)/HIV coinfection has been associated with high mortality and poor TB outcomes. We performed a prospective study to comprehensively characterize a cohort of patients with XDR-TB. Methods Adult patients with XDR-TB were enr…
Marimani M, AlOmar SY, Aldahmash B, Ahmad A, Stacey S, et al.
…ned by the high prevalence of Human Immunodeficiency Virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS) and TB co-infections across different age groups. Epigenetic mechanisms have been widely exploited by Mtb and HIV to bypass the host's innate and ada…
Chingonzoh R, Manesen MR, Madlavu MJ, Sopiseka N, Nokwe M, et al.
…) were male, 68% (n = 982) had MDR-TB, 72% (n = 1,038) were HIV co-infected, and median age was 37 years (Interquartile Range [IQR] 30-46). Patients were at higher risk of mortality during DR-TB treatment if they were HIV co-infected not on antiretroviral treatment (ART) (adjuste…
S. V. Sklyuev, Д. В. Краснов, Yana Petrova, Е. П. Мышкова
…tal, 100 patients with MDR/XDR destructive TB combined with HIV infection participated in the study, of which 60 were randomized to EBV implantation (EBV group), and 40 patients to receive standard medical care (control group). <b>Results:</b> on day 2 of the study in 24(40.0%) p…
Anna Jazza, Eskedar Getie Mekonnen, Helen Cox, Annelies Van Rie
…R-TB and MDR-TB and assess potential effect modification by HIV status during treatment. Methods We conducted an individual patient data meta-analysis involving 16,651 individuals with confirmed drug-resistant tuberculosis, all of whom had drug susceptibility test results for at …
Zhou R, Zheng T, Luo D, Zhu M, Li Q, et al.
…erculosis isolates from patients with tuberculosis (TB) and HIV, and those diagnosed with only TB in Sichuan, China. TB isolates were obtained from January 2018 to December 2020 and subjected to drug susceptibility testing (DST) to 11 anti-TB drugs and to GeneXpert MTB/RIF testin…
Prof Tubonye Harry, Dimie Ogoina, Dr Peter Nwakile, P. Ikuabe, Mr Jonathan Nanakede, et al.
shorter regimens, and 7 (13,2%) -with longer regimens (p < 0.05).Treatment outcomes were not evaluated in 6 patients (10,3%) who had started on shorter regimens and in 9 (17.0%)-on longer regimens (p > 0.05).One patient (1,7%) in the short regimen group died of TB and 2 (3.8%) in…
Zikria Saleem, Masaad Saeed Almutairi, Huda Arooj, Faris S Alnezary
…ON:** The interaction between human immunodeficiency virus (HIV) and tuberculosis (TB) presents a persistent public health challenge, particularly with the emergence of multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB). The Middle East and North Africa (M…
Alexandra Chizhova, Svetlana Safonova, Yulia Mikhajlova, М. А. Краснова, Anastasia Khakhalina, et al.
…(19.8% - 36.4%), and XDR-TB — 5.8% (2.4% - 11.7%). Among TB-HIV patients, there is a large share of DR strains for ethambutol (EMB) 35.0% (p = 0.0160), levofloxacin 20.0% (p = 0.005), and also for ofloxacin (OFL) 25.0% (p = 0.0019). The share of MDR-TB was significantly higher in…
Dipali Maganbhai Gavali, Binita Aring, Summiya Mullan, Akhlak Ahemad
…nd XDR-TB outbreaks have almost invariably been linked with HIV infection, resulting in exceptionally high patient mortality and highlighting the urgent need for rapid diagnosis and intervention in vulnerable populations, DM is a well-known risk factor for TB, and The epidemics o…
Zubeida Salaam-Dreyer, Elizabeth M. Streicher, Frederick A. Sirgel, Fabrizio Menardo, Sònia Borrell, et al.
…multidrug-resistant TB (MDR-TB) within a high TB, RR-TB and HIV burden setting. Patient-level clinical data and stored RR-TB isolates from 2008-2017 with available whole genome sequencing (WGS) data were used to describe risk factors associated with RMR-TB and to compare rifampic…
Silviа Borisova, Н. Б. Бородина
… treatment regimens for patients with such comorbidities as HIV infection and multiple drug resistant and extensively drug resistant tuberculosis. Subjects and Methods. Effectiveness and safety of chemotherapy regimens containing bedaquiline in the treatment of patients in 2017-2…
Erick Manuel Delgado Moya, Alain Piétrus, Sergio Oliva
…l takes into account the relationship between Tuberculosis, HIV/AIDS, and diabetes and differentiates resistance cases into MDR-TB (multidrug-resistant tuberculosis) and XDR-TB (extensively drug-resistant tuberculosis). We present the basic results associated with the model and s…