Showing 51–75 of 200 documents
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Kwon KW, Choi HG, Kim KS, Park SA, Kim HJ, et al.
The quest for effective and enhanced multiantigenic tuberculosis (TB) subunit vaccine necessitates the induction of a protective pathogen-specific immune response while circumventing detrimental inflammation within the lung milieu. In line with this goal, we engineered a modified…
Dijkman K, Lindenstrøm T, Rosenkrands I, Søe R, Woodworth JS, et al.
… resulting in ~1.6 million deaths annually. Protein subunit vaccines have shown promise against TB in clinical studies. Unfortunately, most subunit vaccines require multiple administrations, which increases the risk of loss to follow-up and necessitates more complex and costly lo…
Ian Links, Laurence J. Denholm, Marilyn Evers, L. Kingham, Robert J. Greenstein
Abstract Background Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne’s disease (or paratuberculosis), a chronic wasting disease of ruminants and other animals resulting from granulomatous enteritis. There are increasing concerns that MAP is zoonotic. The prevalence …
Wang H, Wang S, Fang R, Li X, Xing J, et al.
…fforts are underway to accelerate the development of new TB vaccines. However, challenges arise due to the limited immunogenicity and safety of these vaccines, necessitating adjuvants to bolster their ability to elicit a robust immune response for improved and safer immunization.…
Ręka G, Korzeniowska A, Piecewicz-Szczęsna H
The aim of the study Is to present the state of knowledge from April and May 2020 about the influence of Bacillus-Calmette-Guérin vaccination against tuberculosis on incidence and mortality due to COVID-19. Material and methods A review of the latest literature till 9 May 2020 ha…
Wajja A, Namutebi M, Apule B, Oduru G, Kiwanuka S, et al.
…e for tuberculosis (TB) is a global public health priority. Vaccines under development will always need evaluation in endemic settings, most of which have limited resources. Adolescents are an important target population for a new TB vaccine and for other vaccines which are relev…
Jessica E Rothman, Kenneth G Castro, Benjamin A Lopman, Neel R Gandhi, Kristin N Nelson
…to 2,486 (U.S.-born), within the range of established adult vaccines. **SUMMARY LINE:** Targeted vaccination of-infected high-risk persons with an M72/AS01-like vaccine could prevent one tuberculosis case per 217 (HIV) to 2,486 (U.S.-born) persons vaccinated, within the range of…
Angelidou A, Diray-Arce J, Conti MG, Smolen KK, van Haren SD, et al.
Vaccines have been traditionally developed with the presumption that they exert identical immunogenicity regardless of target population and that they provide protection solely against their target pathogen. However, it is increasingly appreciated that vaccines can have off-targe…
Wu Q, Zaid M, Xuan Z, Wang C, Gu H, et al.
…titis and tuberculosis, either by introducing adult booster vaccines or by research into more effective vaccines. Varicella and HFMD are on the rise, but vaccines for these are not included in national programs. Strategies funded by government agencies or encouraged by research i…
Laura Sibley, Andrew White, Karen E. Gooch, Lisa Stevens, Rachel Tanner, et al.
Abstract This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three of the unvaccinated animals w…
Ebenezer Tumban
…-converting enzyme 2 receptor on the cells. Thus, candidate vaccines targeting the spike protein are currently being developed to prevent against infections. Approximately 44 SARS-CoV-2 candidate vaccines are in clinical trials (phase I-III) and an additional 164 candidates are i…
Blok BA, Arts RJW, van Crevel R, Aaby P, Joosten LAB, et al.
…inst tuberculosis, can potentiate immune responses to other vaccines through induction of trained innate immunity and heterologous adaptive immunity. We performed an explorative, randomized, noncontrolled open trial to investigate whether BCG vaccination increases humoral and cel…
Vierboom MPM, Chenine AL, Darrah PA, Vervenne RAW, Boot C, et al.
…ated different routes of administration of vectored subunit vaccines based on chimpanzee-derived adenovirus serotype-3 (ChAd3) for homologous prime-boosting and modified vaccinia virus Ankara (MVA) for heterologous boosting with both vaccine vectors expressing the same antigens f…
Arif Khan, Asad Khan, Irfan Khan, Muhammad Aamir Shehzad, Waqar Ali, et al.
…transformation technique to form a transgenic plant. Edible vaccines grip countless promise as a profitable, easily managing, can be store easily, unlikely or unable to fail and sociocultural gladly sustainable, particularly for the poor emerging nations. An edible vaccine takes …
Vasiliy Reshetnikov, Galina Shepelkova, Anna D. Rybakova, А. П. Трашков, Vladimir Yeremeev, et al.
mRNA vaccines turned out to be highly effective in combating the COVID-19 pandemic and other viral infections. Despite extensive study of mRNA vaccines in the last five years, the issue of safety of their use is still relevant. The study aimed to assess immunogenicity of two anti…
Pérez I, Uranga S, Sayes F, Frigui W, Samper S, et al.
…n a clinical isolate belonging to L4. Here we construct new vaccines based on isogenic gene deletions in clinical isolates of the L2 and L3 modern lineages. These three vaccine candidates were characterized at molecular level and also in animal experiments of protection and safet…
Özgül Kısa
…here isan urgent need for the development of alternative TB vaccines. Recently, new TB vaccine development efforts havebeen advanced in different clinical studies. Most of these vaccines are live-attenuated or recombinant mycobacterium,live viral vector-based, and protein/adjuvan…
Bæk O, Schaltz-Buchholzer F, Campbell A, Amenyogbe N, Campbell J, et al.
…ntentionally targeted pathogen) effects of BCG and smallpox vaccines hold significant translational potential. Yet despite their use for centuries, how scar formation occurs and how local skin-based events relate to systemic effects that allow these two vaccines to deliver powerf…
Chatzikleanthous D, O'Hagan DT, Adamo R
…re are still unmet needs that may enable the development of vaccines suitable for more challenging pathogens (e.g., HIV and tuberculosis) and for cancer vaccines. Liposomes have already been shown to be highly effective as adjuvant/delivery systems due to their versatility and li…
van Meijgaarden KE, Li W, Moorlag SJCFM, Koeken VACM, Koenen HJPM, et al.
Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing mycobacterial growth control, here we f…
Joanna J Regan, Zanju Wang, Christina R Phares
… the 4 weeks following live-virus vaccination because these vaccines are thought to increase the risk of false-negative results. **METHODS:** We retrospectively analyzed TST and IGRA results for 158 484 US-bound immigrant and refugee children aged 2-14 years who received …
Ari MM, Beig M, Sholeh M, Khoshmirsafa M
…usative agent for this infection. Different antibiotics and vaccines have been discussed as potential treatments and prevention. Currently, there is only one licensed vaccine against TB, Bacillus Calmette-Guérin (BCG). Despite its protective efficacy against TB in children, BCG h…
Engi Seif E. Shaker, Noha Nabil Doghim, Arwa M. Hassan, Samia S. Musafa, Mohamed M. Fawzy
BACKGROUND: Warts are common viral infection of the skin. Treating warts are still an ongoing challenge and no general agreement is reached, on the best treatment, despite different therapeutic approaches. Intralesional (IL) immunotherapy has recently been shown to be effective i…
U. Yu. Sirodzhidinova, U. I. Rozikov, S. M. Saydaliev, J. M. Yusupdzhanova
Aim . To study morphological changes in the lymph nodes of experimental animals vaccinated with BCG vaccine in high and low mountains. Material and Methods . Guinea pigs from the vivarium of the Central Research Laboratory of the Avicenna Tajik State Medical University were used …
Александр Сидорчук, Александр Сидорчук
The article describes the historical stages of creating vaccines against two of the most dangerous diseases, which, after the discovery of the microbial theory, were devoted to the efforts of scientists ― rabies and tuberculosis. The lecture describes the main achievements of L. …