Number Needed to Vaccinate with a Novel Tuberculosis Vaccine to Prevent Tuberculosis in High-Risk Populations, United States.
Jessica E Rothman, Kenneth G Castro, Benjamin A Lopman, Neel R Gandhi, Kristin N Nelson
medRxiv : the preprint server for health sciences · 2026-05
Abstract
UNLABELLED: We estimated the number needed to vaccinate (NNV) with an M72/AS01-like vaccine to prevent one tuberculosis case in U.S. high-risk groups. Targeted vaccination of-infected persons yielded NNVs of 217 (persons with HIV) to 2,486 (U.S.-born), within the range of established adult vaccines.
SUMMARY LINE: Targeted vaccination of-infected high-risk persons with an M72/AS01-like vaccine could prevent one tuberculosis case per 217 (HIV) to 2,486 (U.S.-born) persons vaccinated, within the range of established adult vaccines.