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Xie K, Zhang Y, Zhang M, Wu H, Zheng L, et al.
…e disease. VDD is also associated with an increased risk of HIV-related comorbidities and mortality, and patients have a tendency to develop active tuberculosis compared to those with latent tuberculosis infection. Vitamin D supplementation may modulate HIV replication, improve T…
Rao D, Venkataswamy MM, Vasanthapuram R, Satishchandra P, Desai A
Background Neurotuberculosis is one of the commonest HIV associated opportunistic infections of the central nervous system in India. HIV-TB coinfection may lead to altered frequencies of T cells, thereby influencing the course and progression of the disease. Methods We examined t…
Varghese GM, Turaka VP, Janardhanan J, Yadav S, Lakshmi KM, et al.
…e levels of siderocalin in patients with TB with or without HIV infection compared to controls. Methods Siderocalin levels were tested using a neutrophil gelatinase-associated lipocalin (NGAL) ELISA kit in four populations: HIV-infected patients with TB (HIV pos , TB pos ), non-H…
Reid VA, Ramos EI, Veerapandian R, Carmona A, Gadad SS, et al.
…ulosis (TB) is the leading cause of death among people with HIV-1 infection. To improve the diagnosis and treatment of HIV-TB patients, it is important to understand the mechanisms underlying these conditions. Here, we used an integrated genomics approach to analyze and determine…
Gengiah S, Naidoo K, Mlobeli R, Tshabalala MF, Nunn AJ, et al.
Introduction In South Africa, mortality rates among HIV-TB coinfected patients are among the highest in the world. The key to reducing mortality is integrating HIV-TB services, however, a generalizable implementation method and package of tested change ideas to guide the scale-up…
Vanphanom Sychareun, Viengnakhone Vongxay, Souksamone Thongmyxay, Kongmany Chaleunvong, Jo Durham, et al.
…nges in combating the treatable and preventable diseases of HIV/AIDS, tuberculosis (TB), and malaria among priority groups. One priority group are pregnant women. Given increased availability of diagnosis and treatment for these diseases, understanding community knowledge and acc…
Tamene W, Abebe M, Wassie L, Mollalign H, Bauer K, et al.
…tion with PD1 is implicated in immune dysfunction in TB and HIV. The expression of PDL1 on multiple subsets of monocytes as well as their associations with cytokines and microbial products have not been well studied. Method HIV (TB-HIV+), TB (TB+HIV-) and TB/HIV co-infected (TB+H…
Goovaerts O, Massinga-Loembé M, Ondoa P, Ceulemans A, Worodria W, et al.
…ed immune reconstitution inflammatory syndrome (TB-IRIS) in HIV-TB co-infected patients receiving antiretroviral therapy (ART) has been linked to neutrophil activation. Anti-neutrophil cytoplasmic antibodies (ANCAs) are also associated with neutrophil activation. Since ANCAs are …
MacPherson P, Webb EL, Kamchedzera W, Joekes E, Mjoli G, et al.
Background Suboptimal tuberculosis (TB) diagnostics and HIV contribute to the high global burden of TB. We investigated costs and yield from systematic HIV-TB screening, including computer-aided digital chest X-ray (DCXR-CAD). Methods and findings In this open, three-arm randomis…
Mitiku AM, Asfaw GZ, Tsegay HT, Zewdie BY, Tesfay AM
…kground Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) are global public health problems. TB and HIV diagnostic services linkage is imperative for the fight against the two diseases. Objective To assess the diagnostic service linkage and testing of TB-HIV diagnostic ser…
Guita Amane, Paula Simbine, Pereira Zindoga, Algy Abdula, Miguelhete Lisboa
**BACKGROUND:** HIV testing among people with presumptive tuberculosis (PP-TB) represents a critical entry point for HIV diagnosis and care, especially in high-burden settings like Mozambique. However, systematic testing in this population remains suboptimal. This study assessed …
Geetanjali Chander, Nishi Suryavanshi, Nikhil Gupte, Gauri Dhumal, Shatabdi Bagchi, et al.
…ases globally, with approximately 48,000 among persons with HIV (PWH). Unhealthy alcohol use can worsen the health of people who have TB or HIV and those who have both TB and HIV. Behavioral interventions that target alcohol use and are integrated into TB and HIV care may lead to…
Li L, Abudureheman Z, Zhong X, Gong H, Yang F, et al.
…nts who are coinfected with human immunodeficiency virus 1 (HIV) and Mycobacterium tuberculosis (TB) benefit from timely diagnosis and treatment. In the present study frequencies of CD3 + , CD4 + , and CD8 + T cells among peripheral blood mononuclear cells (PBMCs) of patients in …
Zhang SX, Wang JC, Yang J, Lv S, Duan L, et al.
…ackground The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge and is a major global public health issue. This study aims to elucidate the disease burden of HIV-TB co-infecti…
Rupani MP, Vyas S, Shah IA
…etermine the association between catastrophic costs from TB-HIV and TB-diabetes care and unfavorable TB treatment outcomes. Methods We conducted a cohort study in Bhavnagar, India, from July 2019 to January 2021, involving 234 TB-HIV and 304 TB-diabetes patients. Catastrophic cos…
Wang Y, Jing W, Liu J, Liu M
Background People living with human immunodeficiency virus (HIV) are more likely to develop tuberculosis (TB), and their co-infection (HIV-TB) increases the risk of death. We aimed to describe the global trends, regional differences and age distribution of HIV-TB. Methods Annual …
Li L, Abudureheman Z, Zhong X, Gong H, Yangfan, et al.
…nts who are coinfected with human immunodeficiency virus 1 (HIV) and Mycobacterium tuberculosis (TB) benefit from timely diagnosis and treatment. In the present study frequencies of CD3⁺, CD4⁺, and CD8⁺ T cells among peripheral blood mononuclear cells (PBMCs) of patients in the K…
Osei Bonsu E, Addo IY, Adjei BN, Alhassan MM, Nakua EK
…e, treatment outcomes and determinants of tuberculosis (TB)-HIV coinfection in Ghana. Study design A retrospective review of TB case register for Kwabre East Municipality was conducted for the period 2010-2020 to identify TB-HIV coinfections. Setting 462 patients with TB from fou…
Damhorst G, Keener M, Timme E, Venkat H, DeStephens R
… factors for tuberculosis (TB) in the United States include HIV-positive status, birth outside of the United States, incarceration and homelessness. Despite advances in antiretroviral therapy (ART) and declining HIV-TB comorbidity, TB remains an important opportunistic infection …
Granich R, Gupta S
Purpose of review The HIV and Mycobacterium tuberculosis syndemic remains a major global public health threat. HIV and tuberculosis (TB) global targets have been set. Success will depend on achieving combined disease control. We explore current policy, economic investment, and di…
Md Abdul Kuddus, Sazia Khatun Tithi, Anip Kumar Paul, Thitiya Theparod
…tion of Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) remains a significant public health challenge both in Thailand and globally. This dual burden exacerbates disease severity, complicates treatment strategies, and increases mortality rates. In this study, we develope…
Shun-Xian Zhang, Jin-Xin Zheng, Yu Wang, Wen-Wen Lv, Jian Yang, et al.
…e years (DALYs) for TB from 1990 to 2021. Over this period, HIV-negative TB showed a marked decline in ASIR (AAPC = -2.34%, 95% CI: -2.39, -2.28) and ASMR (AAPC = -0.56%, 95% CI: -0.62, -0.59). Specifically, drug-susceptible TB (DS-TB) showed reductions in both ASIR and ASMR, whi…
Li Q, Wang C, Gou J, Kitanovski S, Tang X, et al.
…eading cause of mortality among individuals coinfected with HIV, characterized by progressive pulmonary inflammation. Despite TB's hallmark being focal granulomatous lung lesions, our understanding of the histopathological features and regulation of inflammation in HIV & TB coinf…
Fernandez D, Salami I, Davis J, Mbah F, Kazeem A, et al.
Objective HIV and tuberculosis represent diseases of major public health importance worldwide. Very little is known about HIV-TB coinfection among pregnant women, especially from industrialized settings. In this study, we examined the association between TB, HIV, and HIV-TB coinf…
Balfour A, Schutz C, Goliath R, Wilkinson KA, Sayed S, et al.
…l numbers generally decrease in patients with active TB and HIV infection, but findings regarding functional changes differ. Methods: We conducted a cross-sectional study on the effect of HIV, TB, and HIV-associated TB (HIV-TB) on MAIT cell frequencies, activation and functional …