2263. HIV-TB Co-Infection in Arizona From 1993 to 2016

Abstract Background Key risk factors for tuberculosis (TB) in the United States include HIV-positive status, birth outside of the United States, incarceration and homelessness. Despite advances in antiretroviral therapy (ART) and declining HIV-TB comorbidity, TB remains an important opportunistic infection for all people living with HIV. Few studies exist which characterize HIV-TB co-infection in geographic populations within the United States In this study, we cross-reference the HIV and TB registries in Arizona from 1993 through 2016 and compare features of HIV-TB co-infected individuals with HIV-negative TB cases and the broader population living with HIV. Methods Case records were identified by cross-referencing two separate databases maintained by the Arizona Department of Health Services, the Report of Verified Case of Tuberculosis (RVCT) and the Enhanced HIV/AIDS Reporting System (eHARS). Data were organized and analyzed in SAS and comparisons evaluated with Pearson chi-square test. Results A total of 361 unique cases of HIV-TB co-infection in Arizona were identified during the study period. Annual TB diagnoses in people living with HIV range from 25 (1995) to 7 (2008 and 2016). Significant differences in birth sex and age were observed in HIV-TB co-infections compared with HIV-negative TB cases. Homelessness was more common among people living with HIV (22.6% vs. 9.0%, χ2 = 70.22, P Conclusion Our study reveals important trends in HIV-TB comorbidity in Arizona and may inform public health strategies for addressing TB and its burden among people living with HIV. Disclosures All authors: No reported disclosures.