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М. А. Плеханова, В. А. Аксенова, Л. А. Кривцова
…ctive: to determine predictors of the development of latent tuberculosis infection (LTBI) and tuberculosis in children and adolescents. Subjects and methods . A study was carried out, including testing induced IFN-y and assessment of genotypes of the polymorphic variant of IFNG g…
Krunal Patel, Kinjal Patel, Pooja Gandhi, Bhavini Rathwa, Dipak M. Nakum
Introduction: Tuberculosis is a chronic infectious disease caused by predominantly Mycobacterium tubercle bacilli. Pediatric tuberculosis is among the top 10 causes of death in children. India accounts for one fourth of the global tuberculosis burden, standing one among the thirt…
Dekel Shlomi, Inbal Galor, Anna More, Bernice Oberman, Lizi Fireman
<b>Background:</b> Treatment for latent tuberculosis (TB) is traditionally based on the result of the tuberculin skin test (TST) which is often falsely positive. The Interferon gamma release assays (IGRA) are more specific but considerably more expensive. Several studies have imp…
Lifan Zhang, Huimin Ma, Qiping Ge, Yueqiu Zhang, Xiaochun Shi, et al.
Abstract Background To establish the Mycobacterium tuberculosis (MTB) specific IFN-γ/IL-2/TNF-α-FluoroSpot assay, and preliminarily evaluate its accuracy of differential diagnosis of active tuberculosis (ATB) and latent tuberculosis infection (LTBI). Methods Patients with patholo…
Lynn Sosa, Gibril J. Njie, Mark N. Lobato, Sapna Bamrah Morris, William G. Buchta, et al.
…dated recommendations for screening health care workers for tuberculosis, including eliminating serial screening in the absence of exposure or ongoing transmission. This article presents updated recommendations for screening health care workers for tuberculosis, including elimina…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
Every year, World Tuberculosis (TB) Day is commemorated on March 24 and is targeted at raising public and political awareness of TB, a preventable and treatable disease. World TB Day commemorates the day in 1882 when Professor Robert Koch announced his discovery of the microbial …
Michael Lauzardo, Meghan Nodurft-Froman
Until recently, tuberculosis in children has received little attention from the international public health community, despite it being a key sentinel event indicating recent transmission and hence a window into efforts to control transmission.1Shingadia D Novelli V Diagnosis and…
MV Smilianska, AY Volianskyi, LA Sukhanova, NV Kashpur
…ades, great changes have taken place in the epidemiology of tuberculosis (TB), which are reflected in the change in the statistical indicators of the spread of tuberculosis, due to both the infectious and social nature of the disease. At the end of the 20th century, after a long …
Takele Teklu, Biniam Wondale, Biruhalem Taye, Milkessa Hailemariam, Shiferaw Bekele, et al.
Additional file 4: Supplemental dataset S4. Independent-sample t-tests to identify proteins that were up-regulated or down-regulated upon stimulation with the ESAT-6/CFP-10 antigen cocktail. Fifty-nine proteins were significantly regulated upon stimulation with the ESAT-6/CFP-10 …
Takele Teklu, Biniam Wondale, Biruhalem Taye, Milkessa Hailemariam, Shiferaw Bekele, et al.
Additional file 3: Supplemental database 3. Global ANOVA analysis to identify the proteins that showed significant differences among the eight groups (HC, LTBI, NTM, and TB) in plasma samples with and without stimulation. To perform the quantization analysis, the LFQ values of ea…
Takele Teklu, Biniam Wondale, Biruhalem Taye, Milkessa Hailemariam, Shiferaw Bekele, et al.
Additional file 2: Supplemental dataset S2. Differentially abundance values of proteins comparing four groups (HC, LTBI, NTM and active TB) to each other’s measured from analyzed in two technical replicates computing the abundances with the MaxLFQ software tool. The analytes were…
E. M. Bogorodskaya, E. M. Belilovsky, L. B. Ayusheeva, E. N. Posadskaya
…tients with HIV infection is of the leading risk groups for tuberculosis. According to WHO, the presence of HIV infection increases the likelihood of developing tuberculosis by 26 times and is the second factor in the world after malnutrition that affects the number of cases of t…
Yue Yu, Qiao Yu, Ke Ren Shen, Ding Ting Xu, Wen Hu, et al.
The datasets during the current study are available from the corresponding author upon reasonable request.
G. S. Oganezova, E. M. Bogorodskaya, N. I. Briko, E. M. Belilovsky
…ection not only through the identification of patients with tuberculosis, but also through the identification of patients infected with M. tuberculosis, who still do not have manifestations of a local form of the disease. This made it possible to search for persons who were infec…
Rebecca Berhanu, Karen R. Jacobson
EditorialsOctober 2021Tuberculosis Preventive Therapy for People With HIV Infection in High Tuberculosis Burden Settings: How Much Is Enough?Rebecca H. Berhanu, MD and Karen R. Jacobson, MD, MPHRebecca H. Berhanu, MDBoston University School of Public Health, Boston, Massachusetts…
Cheng Chen, Leonardo Martínez, Biao Xu
…fth of the world population was infected with Mycobacterium tuberculosis (1)，and about 10% of the infected population will finally progress to tuberculosis (TB) disease. The risk of progressing to TB disease was significantly high in the first 2 years of infection (2). However, c…
T.E. Tulkova, Pavel Chernavin, N.P. Chernavin, Yu.P. Chugaev, I.A. Cherniaev, et al.
…ation (WHO), over 23% of the human population infected with tuberculosis bacilli – M.tuberculosis. For each infected person, the likelihood of a transition from a state of latent tuberculosis infection (LTBI) to active tuberculosis remains. WHO considers testing and treatment for…
А. В. Мордык, A. N. Zolotov, Д. Г. Новиков, M. A. Romanova, N. A. Kirichenko, et al.
Publications on the role of neutrophils in tuberculosis are contradictory. The potentially versatile role of neutrophils in the pathogenesis of tuberculosis confirms that the participation of granulocytes in tuberculosis infection is important. Patients and methods. The prospecti…
Gisele Meinerz, Cynthia Keitel da Silva, Damaris Mikaela Balin Dorsdt, Julia Bertoni Adames, Julio Pasquali Andrade, et al.
Background: Tuberculosis (TB) is an important infectious complication after kidney transplantation (KT). Latent tuberculosis infection (LTI) screening and treatment is fundamental to prevent post-transplant active disease. Methods: We described a cohort of adult KT recipients fro…
Seval Özen, Hatice Uygun, Songül Çetin, Cüret Alev, Sadık Akgün, et al.
Objective: Tuberculosis is an important public health problem. Tuberculosis prevalence is high in low-income countries. It is contagious, and therefore a risk for people in public living areas. It is contagious, and therefore a risk for people in public areas. Also, people with i…
Fabrice Uwumuremyi, Samantha Uwayezu, Sylvestre Nzayisenga, Patrick Nemeyimana, Lydivine Mpinganzima, et al.
Background: Tuberculosis is among the most widely spread and serious of all human infectious diseases. About one-third of the world's population is estimated to be infected by Mycobacterium Tuberculosis, in whom active Tuberculosis develops in nine million persons each year. This…
L. V. Slogotskaya, E. M. Bogorodskaya, L. F. Shamuratova, T. A. Sevostyanova
…the study : to compare two approaches to mass screening for tuberculosis infection in children and adolescents in Moscow. Subjects and methods . Two periods have been assessed. Period 1 (2014), when a pilot screening project was implemented in two stages: Stage 1 -all children an…
Cláudia Teresa Vieira de Souza, Maria de Lourdes Benamor Teixeira, Maria Isabel Fragoso da Silveira Gouvêa, Jacob Milnor, José Berilo de Lima Filho, et al.
Tuberculosis is the leading cause of death amongst adults with human immunodeficiency virus (HIV) infection. The lifetime risk of tuberculosis disease for a person with latent infection is estimated at 5-10% with most cases occurring within five years of initial infection. The Wo…
A. V. Lobov, E. A. Pogodina, Patrīcija Ivanova, D.А. Kudlаy, E.V. Sorokina, et al.
…tection of T-cell sensitization are widely used to diagnose tuberculosis infection. These tests belong to the interferon gamma release assay (IGRA) group and play an important role in the diagnosis of latent tuberculosis infection, as well as serving as an alternative to traditio…
Valentina Aksenova, Nadezda I. Klevno, А. И. Казаков, D.А. Kudlаy, T. A. Sevostyanova, et al.
…ologic drugs, GEBD) is associated with a high risk of local tuberculosis (TB) development. Objective. The aim of the study was to examine efficacy of tuberculosis services in children with high risk of developing tuberculosis associated with immunosuppressive therapy. Methods . T…