WHO consolidated guidelines on tuberculosis: module 6: tuberculosis and comorbidities: web annex C: GRADE evidence to decision tables

This web annex presents the GRADE evidence-to-decision tables developed to inform the second edition of Module 6 of the WHO consolidated guidelines on tuberculosis, focusing on tuberculosis and comorbidities, particularly undernutrition. The document summarizes evidence reviewed by the WHO guideline development group regarding nutritional assessment, counselling and support for people with tuberculosis and their household contacts. It examines the relationship between tuberculosis and undernutrition, the role of nutritional interventions in improving treatment outcomes and wellbeing, and operational considerations related to implementation in diverse settings.

The annex evaluates interventions including nutritional assessment and counselling, energy–protein supplementation, micronutrient supplementation, vitamin D, food vouchers, psychosocial counselling and financial support. For each intervention, the document assesses desirable and undesirable effects, certainty of evidence, cost-effectiveness, feasibility, acceptability and equity implications using the GRADE framework. The publication also presents evidence summaries, implementation considerations, subgroup considerations and research priorities supporting WHO recommendations. It was produced to ensure transparency in WHO guideline development and to support evidence-informed policy and programme implementation related to tuberculosis and undernutrition.