In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics
Aono A, Murase Y, Chikamatsu K, Igarashi Y, Shimomura Y, Hosoya M, Osugi A, Morishige Y, et al. (11 authors)
Diagnostic microbiology and infectious disease · 2022-04
Abstract
The effects of tedizolid (TZD) against multidrug-resistant Mycobacterium tuberculosis isolates were investigated. This is possibly the first study to evaluate the MIC of TZD against Japanese Mycobacterium tuberculosis isolates. As TZD had a significantly lower MIC than LZD (P < 0.01), it was suggested to be a better, non-toxic alternative to LZD.
MeSH terms
- Humans
- Mycobacterium tuberculosis
- Tuberculosis, Multidrug-Resistant
- Tetrazoles
- Oxazolidinones
- Anti-Bacterial Agents
- Microbial Sensitivity Tests
- Genomics
- Linezolid