<i>In Vitro</i> and <i>In Vivo</i> Activities of Contezolid (MRX-I) against Mycobacterium tuberculosis
Shoen C, DeStefano M, Hafkin B, Cynamon M
Antimicrobial agents and chemotherapy · 2018-07
Abstract
The in vitro activity of contezolid (MRX-I) against clinical isolates of Mycobacterium tuberculosis was evaluated using a microtiter broth dilution assay. MRX-I was as effective as linezolid (LZD) in vitro MRX-I and LZD were subsequently studied in BALB/c mice infected intranasally with M. tuberculosis Erdman. MRX-I and LZD at 100 mg/kg significantly reduced the bacterial load in lungs compared to the untreated early and late controls.
MeSH terms
- Lung
- Animals
- Mice, Inbred BALB C
- Humans
- Mice
- Mycobacterium tuberculosis
- Tuberculosis, Multidrug-Resistant
- Disease Models, Animal
- Isoniazid
- Tetrazoles
- Oxazolidinones
- Pyridones
- Antitubercular Agents
- Microbial Sensitivity Tests
- Drug Administration Schedule
- Female
- Bacterial Load
- Linezolid