<i>In Vitro</i> and <i>In Vivo</i> Activity of Oxazolidinone Candidate OTB-658 against Mycobacterium tuberculosis
Shaochen Guo, Bin Wang, Lei Fu, Xi Chen, Weiyan Zhang, Hai‐Hong Huang, Yu Lu
Antimicrobial Agents and Chemotherapy · 2021-08
Abstract
In this work, we assess antituberculosis activity of OTB-658 in vitro and in vivo . In vitro , OTB-658 showed bacteriostatic effectiveness with a lower MIC than linezolid against Mycobacterium tuberculosis . The minimal bactericidal concentrations and time-kill curves for OTB-658 indicated inhibition activity similar to that of linezolid.
MeSH terms
- In vivo
- Mycobacterium tuberculosis
- In vitro
- Linezolid
- Microbiology
- Tuberculosis
- Mycobacterium
- Antibacterial agent
- Biology
- Antibiotics
- Medicine